Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? A magnetic resonance imaging study in middle-aged male workers
Abstract Background Modic changes are bone marrow lesions visible in magnetic resonance imaging (MRI), and they are assumed to be associated with symptomatic intervertebral disc disease, especially changes located at L5-S1. Only limited information exists about the determinants of Modic changes. The...
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ftdoajarticles:oai:doaj.org/article:bc84009f4df04ef896c0e61130322966 2023-05-15T17:42:51+02:00 Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? A magnetic resonance imaging study in middle-aged male workers Korpelainen Raija Heliövaara Markku Ojala Risto Niinimäki Jaakko Haapea Marianne Karppinen Jaro Kuisma Mari Kaikkonen Kaisu Taimela Simo Natri Antero Tervonen Osmo 2008-04-01T00:00:00Z https://doi.org/10.1186/1471-2474-9-51 https://doaj.org/article/bc84009f4df04ef896c0e61130322966 EN eng BMC http://www.biomedcentral.com/1471-2474/9/51 https://doaj.org/toc/1471-2474 doi:10.1186/1471-2474-9-51 1471-2474 https://doaj.org/article/bc84009f4df04ef896c0e61130322966 BMC Musculoskeletal Disorders, Vol 9, Iss 1, p 51 (2008) Diseases of the musculoskeletal system RC925-935 article 2008 ftdoajarticles https://doi.org/10.1186/1471-2474-9-51 2022-12-31T07:06:00Z Abstract Background Modic changes are bone marrow lesions visible in magnetic resonance imaging (MRI), and they are assumed to be associated with symptomatic intervertebral disc disease, especially changes located at L5-S1. Only limited information exists about the determinants of Modic changes. The objective of this study was to evaluate the determinants of vertebral endplate (Modic) changes, and whether they are similar for Modic changes and severe disc degeneration focusing on L5-S1 level. Methods 228 middle-aged male workers (159 train engineers and 69 sedentary factory workers) from northern Finland underwent sagittal T1- and T2-weighted MRI. Modic changes and disc degeneration were analyzed from the scans. The participants responded to a questionnaire including items of occupational history and lifestyle factors. Logistic regression analysis was used to evaluate the associations between selected determinants (age, lifetime exercise, weight-related factors, fat percentage, smoking, alcohol use, lifetime whole-body vibration) and Modic type I and II changes, and severe disc degeneration (= grade V on Pfirrmann's classification). Results The prevalences of the Modic changes and severe disc degeneration were similar in the occupational groups. Age was significantly associated with all degenerative changes. In the age-adjusted analyses, only weight-related determinants (BMI, waist circumference) were associated with type II changes. Exposure to whole-body vibration, besides age, was the only significant determinant for severe disc degeneration. In the multivariate model, BMI was associated with type II changes at L5-S1 (OR 2.75 per one SD = 3 unit increment in BMI), and vibration exposure with severe disc degeneration at L5-S1 (OR 1.08 per one SD = 11-year increment in vibration exposure). Conclusion Besides age, weight-related factors seem important in the pathogenesis of Modic changes, whereas whole-body vibration was the only significant determinant of severe disc degeneration. Article in Journal/Newspaper Northern Finland Directory of Open Access Journals: DOAJ Articles BMC Musculoskeletal Disorders 9 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Diseases of the musculoskeletal system RC925-935 |
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Diseases of the musculoskeletal system RC925-935 Korpelainen Raija Heliövaara Markku Ojala Risto Niinimäki Jaakko Haapea Marianne Karppinen Jaro Kuisma Mari Kaikkonen Kaisu Taimela Simo Natri Antero Tervonen Osmo Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? A magnetic resonance imaging study in middle-aged male workers |
topic_facet |
Diseases of the musculoskeletal system RC925-935 |
description |
Abstract Background Modic changes are bone marrow lesions visible in magnetic resonance imaging (MRI), and they are assumed to be associated with symptomatic intervertebral disc disease, especially changes located at L5-S1. Only limited information exists about the determinants of Modic changes. The objective of this study was to evaluate the determinants of vertebral endplate (Modic) changes, and whether they are similar for Modic changes and severe disc degeneration focusing on L5-S1 level. Methods 228 middle-aged male workers (159 train engineers and 69 sedentary factory workers) from northern Finland underwent sagittal T1- and T2-weighted MRI. Modic changes and disc degeneration were analyzed from the scans. The participants responded to a questionnaire including items of occupational history and lifestyle factors. Logistic regression analysis was used to evaluate the associations between selected determinants (age, lifetime exercise, weight-related factors, fat percentage, smoking, alcohol use, lifetime whole-body vibration) and Modic type I and II changes, and severe disc degeneration (= grade V on Pfirrmann's classification). Results The prevalences of the Modic changes and severe disc degeneration were similar in the occupational groups. Age was significantly associated with all degenerative changes. In the age-adjusted analyses, only weight-related determinants (BMI, waist circumference) were associated with type II changes. Exposure to whole-body vibration, besides age, was the only significant determinant for severe disc degeneration. In the multivariate model, BMI was associated with type II changes at L5-S1 (OR 2.75 per one SD = 3 unit increment in BMI), and vibration exposure with severe disc degeneration at L5-S1 (OR 1.08 per one SD = 11-year increment in vibration exposure). Conclusion Besides age, weight-related factors seem important in the pathogenesis of Modic changes, whereas whole-body vibration was the only significant determinant of severe disc degeneration. |
format |
Article in Journal/Newspaper |
author |
Korpelainen Raija Heliövaara Markku Ojala Risto Niinimäki Jaakko Haapea Marianne Karppinen Jaro Kuisma Mari Kaikkonen Kaisu Taimela Simo Natri Antero Tervonen Osmo |
author_facet |
Korpelainen Raija Heliövaara Markku Ojala Risto Niinimäki Jaakko Haapea Marianne Karppinen Jaro Kuisma Mari Kaikkonen Kaisu Taimela Simo Natri Antero Tervonen Osmo |
author_sort |
Korpelainen Raija |
title |
Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? A magnetic resonance imaging study in middle-aged male workers |
title_short |
Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? A magnetic resonance imaging study in middle-aged male workers |
title_full |
Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? A magnetic resonance imaging study in middle-aged male workers |
title_fullStr |
Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? A magnetic resonance imaging study in middle-aged male workers |
title_full_unstemmed |
Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? A magnetic resonance imaging study in middle-aged male workers |
title_sort |
are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? a magnetic resonance imaging study in middle-aged male workers |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1471-2474-9-51 https://doaj.org/article/bc84009f4df04ef896c0e61130322966 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
BMC Musculoskeletal Disorders, Vol 9, Iss 1, p 51 (2008) |
op_relation |
http://www.biomedcentral.com/1471-2474/9/51 https://doaj.org/toc/1471-2474 doi:10.1186/1471-2474-9-51 1471-2474 https://doaj.org/article/bc84009f4df04ef896c0e61130322966 |
op_doi |
https://doi.org/10.1186/1471-2474-9-51 |
container_title |
BMC Musculoskeletal Disorders |
container_volume |
9 |
container_issue |
1 |
_version_ |
1766144769029832704 |