Therapeutic role of Ricinus communis L. and its bioactive compounds in disease prevention and treatment
Ricinus communis L. (R. communis), commonly known as castor oil plant, is used as a traditional natural remedy or folkloric herb for the control and treatment of a wide range of diseases around the globe. Various studies have revealed the presence of diverse phytochemicals such as alkaloids, flavono...
Published in: | Asian Pacific Journal of Tropical Medicine |
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:bc805e12c1a14e82a8d92749fc67be8f 2023-05-15T15:08:04+02:00 Therapeutic role of Ricinus communis L. and its bioactive compounds in disease prevention and treatment Waseem Mohammed Abdul Nahid H Hajrah Jamal S.M. Sabir Saleh M Al-Garni Meshaal J Sabir Saleh A Kabli Kulvinder Singh Saini Roop Singh Bora 2018-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.228431 https://doaj.org/article/bc805e12c1a14e82a8d92749fc67be8f EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=3;spage=177;epage=185;aulast=Abdul https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.228431 https://doaj.org/article/bc805e12c1a14e82a8d92749fc67be8f Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 3, Pp 177-185 (2018) ricinus communis bioactive compounds ethnomedicine molecular targets anti-cancer pharmacology Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.4103/1995-7645.228431 2022-12-31T02:19:33Z Ricinus communis L. (R. communis), commonly known as castor oil plant, is used as a traditional natural remedy or folkloric herb for the control and treatment of a wide range of diseases around the globe. Various studies have revealed the presence of diverse phytochemicals such as alkaloids, flavonoids, terpenes, saponins, phenolic compounds such as kaempferol, gallic acid, ricin, rutin, lupeol, ricinoleic acid, pinene, thujone and gentisic acid. These phytochemicals have been responsible for pharmacological and therapeutic effects, including anticancer, antimicrobial, insecticidal, antioxidant, anti-diabetic, antinociceptive, anti-inflammatory, bone regenerative, analgesic, and anticonvulsant activity. R. communis harbours phytochemicals which have been shown to target peroxisome proliferator activated receptor (PPAR), nuclear factor NF- κ -B, cytochrome p450, P38 mitogen-activated protein kinases kinase (p38 MAPK), tumor protein P53, B-cell lymphoma-extra-large (Bcl-xL) and vascular endothelial growth factor receptor-2 (VEGFR-2). Considering its wide variety of phytochemicals, its pharmacological activity and the subsequent clinical trials, R. communis could be a good candidate for discovering novel complementary drugs. Further experimental and advanced clinical studies are required to explore the pharmaceutical, beneficial therapeutic and safety prospects of R. communis with its phytochemicals as a herbal and complementary medicine for combating various diseases and disorders. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 11 3 177 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
ricinus communis bioactive compounds ethnomedicine molecular targets anti-cancer pharmacology Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
ricinus communis bioactive compounds ethnomedicine molecular targets anti-cancer pharmacology Arctic medicine. Tropical medicine RC955-962 Waseem Mohammed Abdul Nahid H Hajrah Jamal S.M. Sabir Saleh M Al-Garni Meshaal J Sabir Saleh A Kabli Kulvinder Singh Saini Roop Singh Bora Therapeutic role of Ricinus communis L. and its bioactive compounds in disease prevention and treatment |
topic_facet |
ricinus communis bioactive compounds ethnomedicine molecular targets anti-cancer pharmacology Arctic medicine. Tropical medicine RC955-962 |
description |
Ricinus communis L. (R. communis), commonly known as castor oil plant, is used as a traditional natural remedy or folkloric herb for the control and treatment of a wide range of diseases around the globe. Various studies have revealed the presence of diverse phytochemicals such as alkaloids, flavonoids, terpenes, saponins, phenolic compounds such as kaempferol, gallic acid, ricin, rutin, lupeol, ricinoleic acid, pinene, thujone and gentisic acid. These phytochemicals have been responsible for pharmacological and therapeutic effects, including anticancer, antimicrobial, insecticidal, antioxidant, anti-diabetic, antinociceptive, anti-inflammatory, bone regenerative, analgesic, and anticonvulsant activity. R. communis harbours phytochemicals which have been shown to target peroxisome proliferator activated receptor (PPAR), nuclear factor NF- κ -B, cytochrome p450, P38 mitogen-activated protein kinases kinase (p38 MAPK), tumor protein P53, B-cell lymphoma-extra-large (Bcl-xL) and vascular endothelial growth factor receptor-2 (VEGFR-2). Considering its wide variety of phytochemicals, its pharmacological activity and the subsequent clinical trials, R. communis could be a good candidate for discovering novel complementary drugs. Further experimental and advanced clinical studies are required to explore the pharmaceutical, beneficial therapeutic and safety prospects of R. communis with its phytochemicals as a herbal and complementary medicine for combating various diseases and disorders. |
format |
Article in Journal/Newspaper |
author |
Waseem Mohammed Abdul Nahid H Hajrah Jamal S.M. Sabir Saleh M Al-Garni Meshaal J Sabir Saleh A Kabli Kulvinder Singh Saini Roop Singh Bora |
author_facet |
Waseem Mohammed Abdul Nahid H Hajrah Jamal S.M. Sabir Saleh M Al-Garni Meshaal J Sabir Saleh A Kabli Kulvinder Singh Saini Roop Singh Bora |
author_sort |
Waseem Mohammed Abdul |
title |
Therapeutic role of Ricinus communis L. and its bioactive compounds in disease prevention and treatment |
title_short |
Therapeutic role of Ricinus communis L. and its bioactive compounds in disease prevention and treatment |
title_full |
Therapeutic role of Ricinus communis L. and its bioactive compounds in disease prevention and treatment |
title_fullStr |
Therapeutic role of Ricinus communis L. and its bioactive compounds in disease prevention and treatment |
title_full_unstemmed |
Therapeutic role of Ricinus communis L. and its bioactive compounds in disease prevention and treatment |
title_sort |
therapeutic role of ricinus communis l. and its bioactive compounds in disease prevention and treatment |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/1995-7645.228431 https://doaj.org/article/bc805e12c1a14e82a8d92749fc67be8f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 3, Pp 177-185 (2018) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=3;spage=177;epage=185;aulast=Abdul https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.228431 https://doaj.org/article/bc805e12c1a14e82a8d92749fc67be8f |
op_doi |
https://doi.org/10.4103/1995-7645.228431 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
11 |
container_issue |
3 |
container_start_page |
177 |
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1766339496752709632 |