Epidemiology and clinical features of imported malaria: a 14-year retrospective single-centre descriptive study in Prague, Czech Republic
Abstract Background Malaria represents one of the most important imported tropical infectious diseases in European travellers. The objective of the study was to identify changes in the epidemiological features of imported malaria and to analyse the clinical findings and outcomes of imported malaria....
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ftdoajarticles:oai:doaj.org/article:bc7cc26e934c4c96b67a74e51a54b7fc 2023-05-15T15:18:17+02:00 Epidemiology and clinical features of imported malaria: a 14-year retrospective single-centre descriptive study in Prague, Czech Republic Milan Trojánek Vyacheslav Grebenyuk Lenka Richterová Ivana Zicklerová Eva Nohýnková Zdenka Manďáková Jakub Kantor Hana Roháčová František Stejskal 2022-09-01T00:00:00Z https://doi.org/10.1186/s12936-022-04282-8 https://doaj.org/article/bc7cc26e934c4c96b67a74e51a54b7fc EN eng BMC https://doi.org/10.1186/s12936-022-04282-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04282-8 1475-2875 https://doaj.org/article/bc7cc26e934c4c96b67a74e51a54b7fc Malaria Journal, Vol 21, Iss 1, Pp 1-11 (2022) Malaria Imported malaria Travelers Travel medicine Plasmodium Antimalarials Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2022 ftdoajarticles https://doi.org/10.1186/s12936-022-04282-8 2022-12-31T00:38:26Z Abstract Background Malaria represents one of the most important imported tropical infectious diseases in European travellers. The objective of the study was to identify changes in the epidemiological features of imported malaria and to analyse the clinical findings and outcomes of imported malaria. Methods This single-centre descriptive study retrospectively analysed the medical records of all imported malaria cases in travellers treated at the Department of Infectious Diseases of University Hospital Bulovka in Prague from 2006 to 2019. Results The study included 203 patients with a median age of 37 years (IQR 30–48) and a male to female ratio of 3.72:1. Plasmodium falciparum was the predominant species (149/203), and its proportion significantly increased from 35/60 cases (58.3%) in 2006–2011 to 69/80 (86.3%) in 2016–2019 (p < 0.001). In contrast, the incidence of Plasmodium vivax malaria decreased from 19/60 cases (31.7%) in 2006–2011 to 5/80 (6.3%) in 2016–2019 (p < 0.001). Malaria was imported from sub-Saharan Africa in 161/203 cases (79.3%). The proportion of travellers from Southeast and South Asia decreased from 16/60 (26.7%) and 6/60 (10.0%) in 2006–2011 to 2/80 (2.5%) and no cases (0.0%) in 2016–2019, respectively (p < 0.001 and p = 0.006). Tourism was the most common reason for travel (82/203), however, the proportion of non-tourists significantly increased over time from 29/60 (48.3%) in 2006–2011 to 55/80 (68.8%) in 2016–2019, p = 0.015. Severe malaria developed in 32/203 (15.8%) patients who were significantly older (p = 0.013) and whose treatment was delayed (p < 0.001). Two lethal outcomes were observed during the study period. Conclusions This study demonstrated a significant increase in P. falciparum malaria, which frequently resulted in severe disease, especially in older patients and those with delayed treatment initiation. The rising proportion of imported malaria in non-tourists, including business travellers and those visiting friends and relatives, is another characteristic ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 21 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Imported malaria Travelers Travel medicine Plasmodium Antimalarials Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Imported malaria Travelers Travel medicine Plasmodium Antimalarials Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Milan Trojánek Vyacheslav Grebenyuk Lenka Richterová Ivana Zicklerová Eva Nohýnková Zdenka Manďáková Jakub Kantor Hana Roháčová František Stejskal Epidemiology and clinical features of imported malaria: a 14-year retrospective single-centre descriptive study in Prague, Czech Republic |
topic_facet |
Malaria Imported malaria Travelers Travel medicine Plasmodium Antimalarials Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria represents one of the most important imported tropical infectious diseases in European travellers. The objective of the study was to identify changes in the epidemiological features of imported malaria and to analyse the clinical findings and outcomes of imported malaria. Methods This single-centre descriptive study retrospectively analysed the medical records of all imported malaria cases in travellers treated at the Department of Infectious Diseases of University Hospital Bulovka in Prague from 2006 to 2019. Results The study included 203 patients with a median age of 37 years (IQR 30–48) and a male to female ratio of 3.72:1. Plasmodium falciparum was the predominant species (149/203), and its proportion significantly increased from 35/60 cases (58.3%) in 2006–2011 to 69/80 (86.3%) in 2016–2019 (p < 0.001). In contrast, the incidence of Plasmodium vivax malaria decreased from 19/60 cases (31.7%) in 2006–2011 to 5/80 (6.3%) in 2016–2019 (p < 0.001). Malaria was imported from sub-Saharan Africa in 161/203 cases (79.3%). The proportion of travellers from Southeast and South Asia decreased from 16/60 (26.7%) and 6/60 (10.0%) in 2006–2011 to 2/80 (2.5%) and no cases (0.0%) in 2016–2019, respectively (p < 0.001 and p = 0.006). Tourism was the most common reason for travel (82/203), however, the proportion of non-tourists significantly increased over time from 29/60 (48.3%) in 2006–2011 to 55/80 (68.8%) in 2016–2019, p = 0.015. Severe malaria developed in 32/203 (15.8%) patients who were significantly older (p = 0.013) and whose treatment was delayed (p < 0.001). Two lethal outcomes were observed during the study period. Conclusions This study demonstrated a significant increase in P. falciparum malaria, which frequently resulted in severe disease, especially in older patients and those with delayed treatment initiation. The rising proportion of imported malaria in non-tourists, including business travellers and those visiting friends and relatives, is another characteristic ... |
format |
Article in Journal/Newspaper |
author |
Milan Trojánek Vyacheslav Grebenyuk Lenka Richterová Ivana Zicklerová Eva Nohýnková Zdenka Manďáková Jakub Kantor Hana Roháčová František Stejskal |
author_facet |
Milan Trojánek Vyacheslav Grebenyuk Lenka Richterová Ivana Zicklerová Eva Nohýnková Zdenka Manďáková Jakub Kantor Hana Roháčová František Stejskal |
author_sort |
Milan Trojánek |
title |
Epidemiology and clinical features of imported malaria: a 14-year retrospective single-centre descriptive study in Prague, Czech Republic |
title_short |
Epidemiology and clinical features of imported malaria: a 14-year retrospective single-centre descriptive study in Prague, Czech Republic |
title_full |
Epidemiology and clinical features of imported malaria: a 14-year retrospective single-centre descriptive study in Prague, Czech Republic |
title_fullStr |
Epidemiology and clinical features of imported malaria: a 14-year retrospective single-centre descriptive study in Prague, Czech Republic |
title_full_unstemmed |
Epidemiology and clinical features of imported malaria: a 14-year retrospective single-centre descriptive study in Prague, Czech Republic |
title_sort |
epidemiology and clinical features of imported malaria: a 14-year retrospective single-centre descriptive study in prague, czech republic |
publisher |
BMC |
publishDate |
2022 |
url |
https://doi.org/10.1186/s12936-022-04282-8 https://doaj.org/article/bc7cc26e934c4c96b67a74e51a54b7fc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 21, Iss 1, Pp 1-11 (2022) |
op_relation |
https://doi.org/10.1186/s12936-022-04282-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04282-8 1475-2875 https://doaj.org/article/bc7cc26e934c4c96b67a74e51a54b7fc |
op_doi |
https://doi.org/10.1186/s12936-022-04282-8 |
container_title |
Malaria Journal |
container_volume |
21 |
container_issue |
1 |
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1766348484578902016 |