In vivo study of pomegranate (Punica granatum) peel extract efficacy against Giardia lamblia in infected experimental mice
Objective: To investigate the efficacy of pomegranate (Punica granatum) peel extract as an alternative treatment on the white laboratory mice against giardiasis. Methods: Experimental animals were divided into five groups, including Group A: control (infected untreated), Group B: infected and fed wi...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:bba5953681ec419b9fc97abc2ab87631 2023-05-15T15:08:05+02:00 In vivo study of pomegranate (Punica granatum) peel extract efficacy against Giardia lamblia in infected experimental mice Wafa Abdullah Al-Megrin 2017-01-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2016.08.018 https://doaj.org/article/bba5953681ec419b9fc97abc2ab87631 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169116310267 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.08.018 https://doaj.org/article/bba5953681ec419b9fc97abc2ab87631 Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 1, Pp 59-63 (2017) Pomegranate Giardia lamblia Swiss albino mice Saudi Arabia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2017 ftdoajarticles https://doi.org/10.1016/j.apjtb.2016.08.018 2022-12-31T05:54:18Z Objective: To investigate the efficacy of pomegranate (Punica granatum) peel extract as an alternative treatment on the white laboratory mice against giardiasis. Methods: Experimental animals were divided into five groups, including Group A: control (infected untreated), Group B: infected and fed with pectin 7 days before infection, Group C: infected and fed with pectin starting from 7th day of infection, Group D: infected and fed with pomegranate peel extract 7 days before infection, and Group E: infected and fed with pomegranate peel extract starting from 7th day of infection. Results: Results from this study revealed that the prevention rate in the experimental groups reached approximately 50% by the 10th day of using pomegranate peel extract. Moreover, stool cyst counts of groups showed a significant reduction in the shedding of cysts approximately 75.6% by day 20 post-infection. ELISA test showed a reduction in Giardia antigen in the stools of the experimental groups which received pomegranate peel extract. The cure rate of these groups was approximately 97.4% by 28th day of infection. Conclusions: Our present findings indicated that the pomegranate peel extract proved to be valuable in prevention and treatment of Giardia lamblia infection. Further studies are required to determine the effective dose of pomegranate peel extract against Giardia lamblia infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 7 1 59 63 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Pomegranate Giardia lamblia Swiss albino mice Saudi Arabia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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Pomegranate Giardia lamblia Swiss albino mice Saudi Arabia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Wafa Abdullah Al-Megrin In vivo study of pomegranate (Punica granatum) peel extract efficacy against Giardia lamblia in infected experimental mice |
topic_facet |
Pomegranate Giardia lamblia Swiss albino mice Saudi Arabia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate the efficacy of pomegranate (Punica granatum) peel extract as an alternative treatment on the white laboratory mice against giardiasis. Methods: Experimental animals were divided into five groups, including Group A: control (infected untreated), Group B: infected and fed with pectin 7 days before infection, Group C: infected and fed with pectin starting from 7th day of infection, Group D: infected and fed with pomegranate peel extract 7 days before infection, and Group E: infected and fed with pomegranate peel extract starting from 7th day of infection. Results: Results from this study revealed that the prevention rate in the experimental groups reached approximately 50% by the 10th day of using pomegranate peel extract. Moreover, stool cyst counts of groups showed a significant reduction in the shedding of cysts approximately 75.6% by day 20 post-infection. ELISA test showed a reduction in Giardia antigen in the stools of the experimental groups which received pomegranate peel extract. The cure rate of these groups was approximately 97.4% by 28th day of infection. Conclusions: Our present findings indicated that the pomegranate peel extract proved to be valuable in prevention and treatment of Giardia lamblia infection. Further studies are required to determine the effective dose of pomegranate peel extract against Giardia lamblia infection. |
format |
Article in Journal/Newspaper |
author |
Wafa Abdullah Al-Megrin |
author_facet |
Wafa Abdullah Al-Megrin |
author_sort |
Wafa Abdullah Al-Megrin |
title |
In vivo study of pomegranate (Punica granatum) peel extract efficacy against Giardia lamblia in infected experimental mice |
title_short |
In vivo study of pomegranate (Punica granatum) peel extract efficacy against Giardia lamblia in infected experimental mice |
title_full |
In vivo study of pomegranate (Punica granatum) peel extract efficacy against Giardia lamblia in infected experimental mice |
title_fullStr |
In vivo study of pomegranate (Punica granatum) peel extract efficacy against Giardia lamblia in infected experimental mice |
title_full_unstemmed |
In vivo study of pomegranate (Punica granatum) peel extract efficacy against Giardia lamblia in infected experimental mice |
title_sort |
in vivo study of pomegranate (punica granatum) peel extract efficacy against giardia lamblia in infected experimental mice |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2017 |
url |
https://doi.org/10.1016/j.apjtb.2016.08.018 https://doaj.org/article/bba5953681ec419b9fc97abc2ab87631 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 1, Pp 59-63 (2017) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169116310267 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.08.018 https://doaj.org/article/bba5953681ec419b9fc97abc2ab87631 |
op_doi |
https://doi.org/10.1016/j.apjtb.2016.08.018 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
7 |
container_issue |
1 |
container_start_page |
59 |
op_container_end_page |
63 |
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1766339508232519680 |