The impact of KIR/HLA genes on the risk of developing multibacillary leprosy.
BACKGROUND:Killer-cell immunoglobulin-like receptors (KIRs) are a group of regulatory molecules able to activate or inhibit natural killer cells upon interaction with human leukocyte antigen (HLA) class I molecules. Combinations of KIR and HLA may contribute to the occurrence of different immunologi...
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ftdoajarticles:oai:doaj.org/article:bb8c93d78d204c2b980a07ffff9550d6 2023-05-15T15:07:01+02:00 The impact of KIR/HLA genes on the risk of developing multibacillary leprosy. Hugo Vicentin Alves Amarilis Giaretta de Moraes Afonso Carrasco Pepineli Bruna Tiaki Tiyo Quirino Alves de Lima Neto Thais da Silva Santos Jorge Juarez Vieira Teixeira Eliane P Ambrosio-Albuquerque Ana Maria Sell Jeane Eliete Laguila Visentainer 2019-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007696 https://doaj.org/article/bb8c93d78d204c2b980a07ffff9550d6 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6762192?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007696 https://doaj.org/article/bb8c93d78d204c2b980a07ffff9550d6 PLoS Neglected Tropical Diseases, Vol 13, Iss 9, p e0007696 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007696 2022-12-31T10:46:46Z BACKGROUND:Killer-cell immunoglobulin-like receptors (KIRs) are a group of regulatory molecules able to activate or inhibit natural killer cells upon interaction with human leukocyte antigen (HLA) class I molecules. Combinations of KIR and HLA may contribute to the occurrence of different immunological and clinical responses to infectious diseases. Leprosy is a chronic neglected disease, both disabling and disfiguring, caused mainly by Mycobacterium leprae. In this case-control study, we examined the influence of KIRs and HLA ligands on the development of multibacillary leprosy. METHODOLOGY/PRINCIPAL FINDINGS:Genotyping of KIR and HLA genes was performed in 264 multibacillary leprosy patients and 518 healthy unrelated controls (238 healthy household contacts and 280 healthy subjects). These are unprecedented results in which KIR2DL2/KIR2DL2/C1/C2 and KIR2DL3/2DL3/C1/C1 indicated a risk for developing lepromatous and borderline leprosy, respectively. Concerning to 3DL2/A3/A11+, our study demonstrated that independent of control group (contacts or healthy subjects), this KIR receptor and its ligand act as a risk factor for the borderline clinical form. CONCLUSIONS/SIGNIFICANCE:Our finding suggests that synergetic associations of activating and inhibitory KIR genes may alter the balance between these receptors and thus interfere in the progression of multibacillary leprosy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 9 e0007696 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Hugo Vicentin Alves Amarilis Giaretta de Moraes Afonso Carrasco Pepineli Bruna Tiaki Tiyo Quirino Alves de Lima Neto Thais da Silva Santos Jorge Juarez Vieira Teixeira Eliane P Ambrosio-Albuquerque Ana Maria Sell Jeane Eliete Laguila Visentainer The impact of KIR/HLA genes on the risk of developing multibacillary leprosy. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Killer-cell immunoglobulin-like receptors (KIRs) are a group of regulatory molecules able to activate or inhibit natural killer cells upon interaction with human leukocyte antigen (HLA) class I molecules. Combinations of KIR and HLA may contribute to the occurrence of different immunological and clinical responses to infectious diseases. Leprosy is a chronic neglected disease, both disabling and disfiguring, caused mainly by Mycobacterium leprae. In this case-control study, we examined the influence of KIRs and HLA ligands on the development of multibacillary leprosy. METHODOLOGY/PRINCIPAL FINDINGS:Genotyping of KIR and HLA genes was performed in 264 multibacillary leprosy patients and 518 healthy unrelated controls (238 healthy household contacts and 280 healthy subjects). These are unprecedented results in which KIR2DL2/KIR2DL2/C1/C2 and KIR2DL3/2DL3/C1/C1 indicated a risk for developing lepromatous and borderline leprosy, respectively. Concerning to 3DL2/A3/A11+, our study demonstrated that independent of control group (contacts or healthy subjects), this KIR receptor and its ligand act as a risk factor for the borderline clinical form. CONCLUSIONS/SIGNIFICANCE:Our finding suggests that synergetic associations of activating and inhibitory KIR genes may alter the balance between these receptors and thus interfere in the progression of multibacillary leprosy. |
format |
Article in Journal/Newspaper |
author |
Hugo Vicentin Alves Amarilis Giaretta de Moraes Afonso Carrasco Pepineli Bruna Tiaki Tiyo Quirino Alves de Lima Neto Thais da Silva Santos Jorge Juarez Vieira Teixeira Eliane P Ambrosio-Albuquerque Ana Maria Sell Jeane Eliete Laguila Visentainer |
author_facet |
Hugo Vicentin Alves Amarilis Giaretta de Moraes Afonso Carrasco Pepineli Bruna Tiaki Tiyo Quirino Alves de Lima Neto Thais da Silva Santos Jorge Juarez Vieira Teixeira Eliane P Ambrosio-Albuquerque Ana Maria Sell Jeane Eliete Laguila Visentainer |
author_sort |
Hugo Vicentin Alves |
title |
The impact of KIR/HLA genes on the risk of developing multibacillary leprosy. |
title_short |
The impact of KIR/HLA genes on the risk of developing multibacillary leprosy. |
title_full |
The impact of KIR/HLA genes on the risk of developing multibacillary leprosy. |
title_fullStr |
The impact of KIR/HLA genes on the risk of developing multibacillary leprosy. |
title_full_unstemmed |
The impact of KIR/HLA genes on the risk of developing multibacillary leprosy. |
title_sort |
impact of kir/hla genes on the risk of developing multibacillary leprosy. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007696 https://doaj.org/article/bb8c93d78d204c2b980a07ffff9550d6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 9, p e0007696 (2019) |
op_relation |
http://europepmc.org/articles/PMC6762192?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007696 https://doaj.org/article/bb8c93d78d204c2b980a07ffff9550d6 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007696 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
9 |
container_start_page |
e0007696 |
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1766338599534460928 |