Vector competence of biting midges and mosquitoes for Shuni virus.
Background Shuni virus (SHUV) is an orthobunyavirus that belongs to the Simbu serogroup. SHUV was isolated from diverse species of domesticated animals and wildlife, and is associated with neurological disease, abortions, and congenital malformations. Recently, SHUV caused outbreaks among ruminants...
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ftdoajarticles:oai:doaj.org/article:bb6de438f6544d07b6398a41544c850f 2023-05-15T15:11:30+02:00 Vector competence of biting midges and mosquitoes for Shuni virus. Tim W R Möhlmann Judith Oymans Paul J Wichgers Schreur Constantianus J M Koenraadt Jeroen Kortekaas Chantal B F Vogels 2019-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006609 https://doaj.org/article/bb6de438f6544d07b6398a41544c850f EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0006609 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006609 https://doaj.org/article/bb6de438f6544d07b6398a41544c850f PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0006609 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006609 2022-12-31T04:00:05Z Background Shuni virus (SHUV) is an orthobunyavirus that belongs to the Simbu serogroup. SHUV was isolated from diverse species of domesticated animals and wildlife, and is associated with neurological disease, abortions, and congenital malformations. Recently, SHUV caused outbreaks among ruminants in Israel, representing the first incursions outside the African continent. The isolation of SHUV from a febrile child in Nigeria and seroprevalence among veterinarians in South Africa suggests that the virus may have zoonotic potential as well. The high pathogenicity, extremely broad tropism, potential transmission via both biting midges and mosquitoes, and zoonotic features of SHUV require further investigation. This is important to accurately determine the risk for animal and human health, and to facilitate preparations for potential epidemics. To gain first insight into the potential involvement of biting midges and mosquitoes in SHUV transmission we have investigated the ability of SHUV to infect two species of laboratory-colonised biting midges and two species of mosquitoes. Methodology/principal findings Culicoides nubeculosus, C. sonorensis, Culex pipiens pipiens, and Aedes aegypti were orally exposed to SHUV by providing an infectious blood meal. Biting midges showed high infection rates of approximately 40%-60%, whereas infection rates of mosquitoes were only 0-2%. Moreover, successful dissemination in both species of biting midges and no evidence for transmission by orally exposed mosquitoes was found. Conclusions/significance The results of this study suggest that different species of Culicoides midges are efficient in SHUV transmission, while the involvement of mosquitoes has not been supported. Article in Journal/Newspaper Arctic Human health Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 2 e0006609 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tim W R Möhlmann Judith Oymans Paul J Wichgers Schreur Constantianus J M Koenraadt Jeroen Kortekaas Chantal B F Vogels Vector competence of biting midges and mosquitoes for Shuni virus. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Shuni virus (SHUV) is an orthobunyavirus that belongs to the Simbu serogroup. SHUV was isolated from diverse species of domesticated animals and wildlife, and is associated with neurological disease, abortions, and congenital malformations. Recently, SHUV caused outbreaks among ruminants in Israel, representing the first incursions outside the African continent. The isolation of SHUV from a febrile child in Nigeria and seroprevalence among veterinarians in South Africa suggests that the virus may have zoonotic potential as well. The high pathogenicity, extremely broad tropism, potential transmission via both biting midges and mosquitoes, and zoonotic features of SHUV require further investigation. This is important to accurately determine the risk for animal and human health, and to facilitate preparations for potential epidemics. To gain first insight into the potential involvement of biting midges and mosquitoes in SHUV transmission we have investigated the ability of SHUV to infect two species of laboratory-colonised biting midges and two species of mosquitoes. Methodology/principal findings Culicoides nubeculosus, C. sonorensis, Culex pipiens pipiens, and Aedes aegypti were orally exposed to SHUV by providing an infectious blood meal. Biting midges showed high infection rates of approximately 40%-60%, whereas infection rates of mosquitoes were only 0-2%. Moreover, successful dissemination in both species of biting midges and no evidence for transmission by orally exposed mosquitoes was found. Conclusions/significance The results of this study suggest that different species of Culicoides midges are efficient in SHUV transmission, while the involvement of mosquitoes has not been supported. |
format |
Article in Journal/Newspaper |
author |
Tim W R Möhlmann Judith Oymans Paul J Wichgers Schreur Constantianus J M Koenraadt Jeroen Kortekaas Chantal B F Vogels |
author_facet |
Tim W R Möhlmann Judith Oymans Paul J Wichgers Schreur Constantianus J M Koenraadt Jeroen Kortekaas Chantal B F Vogels |
author_sort |
Tim W R Möhlmann |
title |
Vector competence of biting midges and mosquitoes for Shuni virus. |
title_short |
Vector competence of biting midges and mosquitoes for Shuni virus. |
title_full |
Vector competence of biting midges and mosquitoes for Shuni virus. |
title_fullStr |
Vector competence of biting midges and mosquitoes for Shuni virus. |
title_full_unstemmed |
Vector competence of biting midges and mosquitoes for Shuni virus. |
title_sort |
vector competence of biting midges and mosquitoes for shuni virus. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0006609 https://doaj.org/article/bb6de438f6544d07b6398a41544c850f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Human health |
genre_facet |
Arctic Human health |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0006609 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0006609 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006609 https://doaj.org/article/bb6de438f6544d07b6398a41544c850f |
op_doi |
https://doi.org/10.1371/journal.pntd.0006609 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
2 |
container_start_page |
e0006609 |
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1766342350667251712 |