Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs.
Rabies is traditionally considered a uniformly fatal disease after onset of clinical manifestations. However, increasing evidence indicates that non-lethal infection as well as recovery from flaccid paralysis and encephalitis occurs in laboratory animals as well as humans.Non-lethal rabies infection...
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ftdoajarticles:oai:doaj.org/article:bb2a88df811948c59f660ce416db4bff 2023-05-15T15:10:02+02:00 Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs. Clement W Gnanadurai Ming Zhou Wenqi He Christina M Leyson Chien-Tsun Huang Gregory Salyards Stephen B Harvey Zhenhai Chen Biao He Yang Yang D C Hooper Berhnard Dietzchold Zhen F Fu 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002375 https://doaj.org/article/bb2a88df811948c59f660ce416db4bff EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3777866?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002375 https://doaj.org/article/bb2a88df811948c59f660ce416db4bff PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2375 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002375 2022-12-31T13:35:31Z Rabies is traditionally considered a uniformly fatal disease after onset of clinical manifestations. However, increasing evidence indicates that non-lethal infection as well as recovery from flaccid paralysis and encephalitis occurs in laboratory animals as well as humans.Non-lethal rabies infection in dogs experimentally infected with wild type dog rabies virus (RABV, wt DRV-Mexico) correlates with the presence of high level of virus neutralizing antibodies (VNA) in the cerebral spinal fluid (CSF) and mild immune cell accumulation in the central nervous system (CNS). By contrast, dogs that succumbed to rabies showed only little or no VNA in the serum or in the CSF and severe inflammation in the CNS. Dogs vaccinated with a rabies vaccine showed no clinical signs of rabies and survived challenge with a lethal dose of wild-type DRV. VNA was detected in the serum, but not in the CSF of immunized dogs. Thus the presence of VNA is critical for inhibiting virus spread within the CNS and eventually clearing the virus from the CNS.Non-lethal infection with wt RABV correlates with the presence of VNA in the CNS. Therefore production of VNA within the CNS or invasion of VNA from the periphery into the CNS via compromised blood-brain barrier is important for clearing the virus infection from CNS, thereby preventing an otherwise lethal rabies virus infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 9 e2375 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Clement W Gnanadurai Ming Zhou Wenqi He Christina M Leyson Chien-Tsun Huang Gregory Salyards Stephen B Harvey Zhenhai Chen Biao He Yang Yang D C Hooper Berhnard Dietzchold Zhen F Fu Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Rabies is traditionally considered a uniformly fatal disease after onset of clinical manifestations. However, increasing evidence indicates that non-lethal infection as well as recovery from flaccid paralysis and encephalitis occurs in laboratory animals as well as humans.Non-lethal rabies infection in dogs experimentally infected with wild type dog rabies virus (RABV, wt DRV-Mexico) correlates with the presence of high level of virus neutralizing antibodies (VNA) in the cerebral spinal fluid (CSF) and mild immune cell accumulation in the central nervous system (CNS). By contrast, dogs that succumbed to rabies showed only little or no VNA in the serum or in the CSF and severe inflammation in the CNS. Dogs vaccinated with a rabies vaccine showed no clinical signs of rabies and survived challenge with a lethal dose of wild-type DRV. VNA was detected in the serum, but not in the CSF of immunized dogs. Thus the presence of VNA is critical for inhibiting virus spread within the CNS and eventually clearing the virus from the CNS.Non-lethal infection with wt RABV correlates with the presence of VNA in the CNS. Therefore production of VNA within the CNS or invasion of VNA from the periphery into the CNS via compromised blood-brain barrier is important for clearing the virus infection from CNS, thereby preventing an otherwise lethal rabies virus infection. |
format |
Article in Journal/Newspaper |
author |
Clement W Gnanadurai Ming Zhou Wenqi He Christina M Leyson Chien-Tsun Huang Gregory Salyards Stephen B Harvey Zhenhai Chen Biao He Yang Yang D C Hooper Berhnard Dietzchold Zhen F Fu |
author_facet |
Clement W Gnanadurai Ming Zhou Wenqi He Christina M Leyson Chien-Tsun Huang Gregory Salyards Stephen B Harvey Zhenhai Chen Biao He Yang Yang D C Hooper Berhnard Dietzchold Zhen F Fu |
author_sort |
Clement W Gnanadurai |
title |
Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs. |
title_short |
Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs. |
title_full |
Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs. |
title_fullStr |
Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs. |
title_full_unstemmed |
Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs. |
title_sort |
presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002375 https://doaj.org/article/bb2a88df811948c59f660ce416db4bff |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2375 (2013) |
op_relation |
http://europepmc.org/articles/PMC3777866?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002375 https://doaj.org/article/bb2a88df811948c59f660ce416db4bff |
op_doi |
https://doi.org/10.1371/journal.pntd.0002375 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
7 |
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9 |
container_start_page |
e2375 |
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1766341106962792448 |