Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe
The picornavirus named ‘Ljungan virus’ (LV, species Parechovirus B ) has been detected in a dozen small mammal species from across Europe, but detailed information on its genetic diversity and host specificity is lacking. Here, we analyze the evolutionary relationships of LV variants circulating in...
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ftdoajarticles:oai:doaj.org/article:bb19b9d0477b4b37b6bd9da38ac0cd99 2023-05-15T17:12:36+02:00 Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe Chiara Rossi Nicola Zadra Cristina Fevola Frauke Ecke Birger Hörnfeldt René Kallies Maria Kazimirova Magnus Magnusson Gert E. Olsson Rainer G. Ulrich Anne J. Jääskeläinen Heikki Henttonen Heidi C. Hauffe 2021-07-01T00:00:00Z https://doi.org/10.3390/v13071317 https://doaj.org/article/bb19b9d0477b4b37b6bd9da38ac0cd99 EN eng MDPI AG https://www.mdpi.com/1999-4915/13/7/1317 https://doaj.org/toc/1999-4915 doi:10.3390/v13071317 1999-4915 https://doaj.org/article/bb19b9d0477b4b37b6bd9da38ac0cd99 Viruses, Vol 13, Iss 1317, p 1317 (2021) Picornaviridae Parechovirus B Ljungan virus isolates small mammals rodent-borne virus zoonosis Microbiology QR1-502 article 2021 ftdoajarticles https://doi.org/10.3390/v13071317 2022-12-31T13:16:57Z The picornavirus named ‘Ljungan virus’ (LV, species Parechovirus B ) has been detected in a dozen small mammal species from across Europe, but detailed information on its genetic diversity and host specificity is lacking. Here, we analyze the evolutionary relationships of LV variants circulating in free-living mammal populations by comparing the phylogenetics of the VP1 region (encoding the capsid protein and associated with LV serotype) and the 3D pol region (encoding the RNA polymerase) from 24 LV RNA-positive animals and a fragment of the 5′ untranslated region (UTR) sequence (used for defining strains) in sympatric small mammals. We define three new VP1 genotypes: two in bank voles ( Myodes glareolus ) (genotype 8 from Finland, Sweden, France, and Italy, and genotype 9 from France and Italy) and one in field voles ( Microtus arvalis ) (genotype 7 from Finland). There are several other indications that LV variants are host-specific, at least in parts of their range. Our results suggest that LV evolution is rapid, ongoing and affected by genetic drift, purifying selection, spillover and host evolutionary history. Although recent studies suggest that LV does not have zoonotic potential, its widespread geographical and host distribution in natural populations of well-characterized small mammals could make it useful as a model for studying RNA virus evolution and transmission. Article in Journal/Newspaper Microtus arvalis Directory of Open Access Journals: DOAJ Articles Viruses 13 7 1317 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Picornaviridae Parechovirus B Ljungan virus isolates small mammals rodent-borne virus zoonosis Microbiology QR1-502 |
spellingShingle |
Picornaviridae Parechovirus B Ljungan virus isolates small mammals rodent-borne virus zoonosis Microbiology QR1-502 Chiara Rossi Nicola Zadra Cristina Fevola Frauke Ecke Birger Hörnfeldt René Kallies Maria Kazimirova Magnus Magnusson Gert E. Olsson Rainer G. Ulrich Anne J. Jääskeläinen Heikki Henttonen Heidi C. Hauffe Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe |
topic_facet |
Picornaviridae Parechovirus B Ljungan virus isolates small mammals rodent-borne virus zoonosis Microbiology QR1-502 |
description |
The picornavirus named ‘Ljungan virus’ (LV, species Parechovirus B ) has been detected in a dozen small mammal species from across Europe, but detailed information on its genetic diversity and host specificity is lacking. Here, we analyze the evolutionary relationships of LV variants circulating in free-living mammal populations by comparing the phylogenetics of the VP1 region (encoding the capsid protein and associated with LV serotype) and the 3D pol region (encoding the RNA polymerase) from 24 LV RNA-positive animals and a fragment of the 5′ untranslated region (UTR) sequence (used for defining strains) in sympatric small mammals. We define three new VP1 genotypes: two in bank voles ( Myodes glareolus ) (genotype 8 from Finland, Sweden, France, and Italy, and genotype 9 from France and Italy) and one in field voles ( Microtus arvalis ) (genotype 7 from Finland). There are several other indications that LV variants are host-specific, at least in parts of their range. Our results suggest that LV evolution is rapid, ongoing and affected by genetic drift, purifying selection, spillover and host evolutionary history. Although recent studies suggest that LV does not have zoonotic potential, its widespread geographical and host distribution in natural populations of well-characterized small mammals could make it useful as a model for studying RNA virus evolution and transmission. |
format |
Article in Journal/Newspaper |
author |
Chiara Rossi Nicola Zadra Cristina Fevola Frauke Ecke Birger Hörnfeldt René Kallies Maria Kazimirova Magnus Magnusson Gert E. Olsson Rainer G. Ulrich Anne J. Jääskeläinen Heikki Henttonen Heidi C. Hauffe |
author_facet |
Chiara Rossi Nicola Zadra Cristina Fevola Frauke Ecke Birger Hörnfeldt René Kallies Maria Kazimirova Magnus Magnusson Gert E. Olsson Rainer G. Ulrich Anne J. Jääskeläinen Heikki Henttonen Heidi C. Hauffe |
author_sort |
Chiara Rossi |
title |
Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe |
title_short |
Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe |
title_full |
Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe |
title_fullStr |
Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe |
title_full_unstemmed |
Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe |
title_sort |
evolutionary relationships of ljungan virus variants circulating in multi-host systems across europe |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doi.org/10.3390/v13071317 https://doaj.org/article/bb19b9d0477b4b37b6bd9da38ac0cd99 |
genre |
Microtus arvalis |
genre_facet |
Microtus arvalis |
op_source |
Viruses, Vol 13, Iss 1317, p 1317 (2021) |
op_relation |
https://www.mdpi.com/1999-4915/13/7/1317 https://doaj.org/toc/1999-4915 doi:10.3390/v13071317 1999-4915 https://doaj.org/article/bb19b9d0477b4b37b6bd9da38ac0cd99 |
op_doi |
https://doi.org/10.3390/v13071317 |
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Viruses |
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13 |
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7 |
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1317 |
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1766069380034068480 |