Protective capacity of Artemisia annua as a potent antioxidant remedy against free radical damage
Objective: To evaluate the antioxidant capacity of four leaf-derived solvent extracts of Artemisia annua (A. annua), a medicinal plant widely touted for its vast phyto-therapeutic potential. Methods: A. annua leaves were extracted with four solvents (absolute ethanol, absolute methanol, 70% ethanol...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
2014
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ftdoajarticles:oai:doaj.org/article:bb0670560e88477d941f46a996bbab81 2023-05-15T15:05:45+02:00 Protective capacity of Artemisia annua as a potent antioxidant remedy against free radical damage Peter Nkachukwu Chukwurah Ebiamadon Andi Brisibe Aniefiok Ndubuisi Osuagwu Tebekeme Okoko 2014-05-01T00:00:00Z https://doi.org/10.12980/APJTB.4.2014C731 https://doaj.org/article/bb0670560e88477d941f46a996bbab81 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115302513 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014C731 https://doaj.org/article/bb0670560e88477d941f46a996bbab81 Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S1, Pp S92-S98 (2014) Antioxidants Artemisia annua Free radicals Phyto-protection Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2014 ftdoajarticles https://doi.org/10.12980/APJTB.4.2014C731 2022-12-31T05:20:11Z Objective: To evaluate the antioxidant capacity of four leaf-derived solvent extracts of Artemisia annua (A. annua), a medicinal plant widely touted for its vast phyto-therapeutic potential. Methods: A. annua leaves were extracted with four solvents (absolute ethanol, absolute methanol, 70% ethanol and 70% methanol), and extracts obtained studied by five complementary in vitro antioxidant test systems using ascorbic acid (vitamin C) and rutin as standard references. Results: The extracts remarkably inhibited lipid peroxidation (79.81%-86.70%), and erythrocyte haemolysis (40.02%-49.91%). Their IC50 values for hydroxyl, nitric oxide and hydrogen peroxide radical scavenging activities ranged from 2.39–3.81 mg/mL (superior to the standards), 107.24–144.49 μg/mL and 28.53–53.20 μg/mL, respectively. 70% alcohol extracts generally showed better antioxidant activity than absolute alcohol extracts. Conclusions: The results indicate that A. annua leaf extracts have potent antioxidant activities that would have beneficial effect on human health, and aqueous organic solvents are superior to the absolute counterparts in yielding extracts with better antioxidant potential. Article in Journal/Newspaper Arctic Human health Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 4 S92 S98 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Antioxidants Artemisia annua Free radicals Phyto-protection Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Antioxidants Artemisia annua Free radicals Phyto-protection Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Peter Nkachukwu Chukwurah Ebiamadon Andi Brisibe Aniefiok Ndubuisi Osuagwu Tebekeme Okoko Protective capacity of Artemisia annua as a potent antioxidant remedy against free radical damage |
topic_facet |
Antioxidants Artemisia annua Free radicals Phyto-protection Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the antioxidant capacity of four leaf-derived solvent extracts of Artemisia annua (A. annua), a medicinal plant widely touted for its vast phyto-therapeutic potential. Methods: A. annua leaves were extracted with four solvents (absolute ethanol, absolute methanol, 70% ethanol and 70% methanol), and extracts obtained studied by five complementary in vitro antioxidant test systems using ascorbic acid (vitamin C) and rutin as standard references. Results: The extracts remarkably inhibited lipid peroxidation (79.81%-86.70%), and erythrocyte haemolysis (40.02%-49.91%). Their IC50 values for hydroxyl, nitric oxide and hydrogen peroxide radical scavenging activities ranged from 2.39–3.81 mg/mL (superior to the standards), 107.24–144.49 μg/mL and 28.53–53.20 μg/mL, respectively. 70% alcohol extracts generally showed better antioxidant activity than absolute alcohol extracts. Conclusions: The results indicate that A. annua leaf extracts have potent antioxidant activities that would have beneficial effect on human health, and aqueous organic solvents are superior to the absolute counterparts in yielding extracts with better antioxidant potential. |
format |
Article in Journal/Newspaper |
author |
Peter Nkachukwu Chukwurah Ebiamadon Andi Brisibe Aniefiok Ndubuisi Osuagwu Tebekeme Okoko |
author_facet |
Peter Nkachukwu Chukwurah Ebiamadon Andi Brisibe Aniefiok Ndubuisi Osuagwu Tebekeme Okoko |
author_sort |
Peter Nkachukwu Chukwurah |
title |
Protective capacity of Artemisia annua as a potent antioxidant remedy against free radical damage |
title_short |
Protective capacity of Artemisia annua as a potent antioxidant remedy against free radical damage |
title_full |
Protective capacity of Artemisia annua as a potent antioxidant remedy against free radical damage |
title_fullStr |
Protective capacity of Artemisia annua as a potent antioxidant remedy against free radical damage |
title_full_unstemmed |
Protective capacity of Artemisia annua as a potent antioxidant remedy against free radical damage |
title_sort |
protective capacity of artemisia annua as a potent antioxidant remedy against free radical damage |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2014 |
url |
https://doi.org/10.12980/APJTB.4.2014C731 https://doaj.org/article/bb0670560e88477d941f46a996bbab81 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Human health |
genre_facet |
Arctic Human health |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S1, Pp S92-S98 (2014) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115302513 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014C731 https://doaj.org/article/bb0670560e88477d941f46a996bbab81 |
op_doi |
https://doi.org/10.12980/APJTB.4.2014C731 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
4 |
container_start_page |
S92 |
op_container_end_page |
S98 |
_version_ |
1766337402037600256 |