Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis
A total of 1,263 adults from Newfoundland and Labrador were studied in the research. Body mass index (BMI) and percent trunk fat (PTF) were analyzed as biomarkers for obesity. The Mendelian randomization (MR) approach with two single-nucleotide polymorphisms in the fat-mass and obesity (FTO) gene as...
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ftdoajarticles:oai:doaj.org/article:baf8629da23e4d2993b62ef8de47197b 2023-05-15T17:21:18+02:00 Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis Frank Barning Taraneh Abarin 2016-01-01T00:00:00Z https://doi.org/10.4137/GEG.S38289 https://doaj.org/article/baf8629da23e4d2993b62ef8de47197b EN eng SAGE Publishing https://doi.org/10.4137/GEG.S38289 https://doaj.org/toc/1179-237X 1179-237X doi:10.4137/GEG.S38289 https://doaj.org/article/baf8629da23e4d2993b62ef8de47197b Genetics and Epigenetics, Vol 8 (2016) Genetics QH426-470 article 2016 ftdoajarticles https://doi.org/10.4137/GEG.S38289 2022-12-31T13:03:01Z A total of 1,263 adults from Newfoundland and Labrador were studied in the research. Body mass index (BMI) and percent trunk fat (PTF) were analyzed as biomarkers for obesity. The Mendelian randomization (MR) approach with two single-nucleotide polymorphisms in the fat-mass and obesity (FTO) gene as instruments was employed to assess the causal effect. In both genders, increasing physical activity significantly reduced BMI and PTF when adjusted for age and the FTO gene. The effect of physical activity was stronger on PTF than BMI. Direct observational analyses showed significant increase in BMI/PTF when physical activity decreased. A similar association in MR analyses was not significant. The association between physical activity and BMI/PTF could be due to reversed causality or common confounding factors. Our study provides insights into the causal contributions of obesity to physical activity in adults. Health intervention strategies to increase physical activity among adults should include some other plans such as improving diet for reducing obesity. Article in Journal/Newspaper Newfoundland Directory of Open Access Journals: DOAJ Articles Newfoundland Genetics & Epigenetics 8 GEG.S38289 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Genetics QH426-470 |
spellingShingle |
Genetics QH426-470 Frank Barning Taraneh Abarin Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis |
topic_facet |
Genetics QH426-470 |
description |
A total of 1,263 adults from Newfoundland and Labrador were studied in the research. Body mass index (BMI) and percent trunk fat (PTF) were analyzed as biomarkers for obesity. The Mendelian randomization (MR) approach with two single-nucleotide polymorphisms in the fat-mass and obesity (FTO) gene as instruments was employed to assess the causal effect. In both genders, increasing physical activity significantly reduced BMI and PTF when adjusted for age and the FTO gene. The effect of physical activity was stronger on PTF than BMI. Direct observational analyses showed significant increase in BMI/PTF when physical activity decreased. A similar association in MR analyses was not significant. The association between physical activity and BMI/PTF could be due to reversed causality or common confounding factors. Our study provides insights into the causal contributions of obesity to physical activity in adults. Health intervention strategies to increase physical activity among adults should include some other plans such as improving diet for reducing obesity. |
format |
Article in Journal/Newspaper |
author |
Frank Barning Taraneh Abarin |
author_facet |
Frank Barning Taraneh Abarin |
author_sort |
Frank Barning |
title |
Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis |
title_short |
Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis |
title_full |
Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis |
title_fullStr |
Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis |
title_full_unstemmed |
Assessing the Causality Factors in the Association between (Abdominal) Obesity and Physical Activity among the Newfoundland Population–-A Mendelian Randomization Analysis |
title_sort |
assessing the causality factors in the association between (abdominal) obesity and physical activity among the newfoundland population–-a mendelian randomization analysis |
publisher |
SAGE Publishing |
publishDate |
2016 |
url |
https://doi.org/10.4137/GEG.S38289 https://doaj.org/article/baf8629da23e4d2993b62ef8de47197b |
geographic |
Newfoundland |
geographic_facet |
Newfoundland |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Genetics and Epigenetics, Vol 8 (2016) |
op_relation |
https://doi.org/10.4137/GEG.S38289 https://doaj.org/toc/1179-237X 1179-237X doi:10.4137/GEG.S38289 https://doaj.org/article/baf8629da23e4d2993b62ef8de47197b |
op_doi |
https://doi.org/10.4137/GEG.S38289 |
container_title |
Genetics & Epigenetics |
container_volume |
8 |
container_start_page |
GEG.S38289 |
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1766105188007936000 |