Genomic Characterization of Three Canadian Mumps Outbreaks Demonstrates Endemic Transmission in Canada
Despite the provision of a mumps vaccination program in Canada for over three decades, mumps has not reached elimination. Instead, a re-emergence has been observed in vaccinated populations, particularly in young adults. These outbreaks have been almost exclusively due to genotype G infections, a tr...
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ftdoajarticles:oai:doaj.org/article:bada27fc9a744089921eb38b32e5efca 2024-09-15T18:20:12+00:00 Genomic Characterization of Three Canadian Mumps Outbreaks Demonstrates Endemic Transmission in Canada Jasmine Rae Frost Grace Eunchong Seo Kerry Dust Jared Bullard Peter Daley Jason J. LeBlanc Joanne Hiebert Elizabeth McLachlan Alberto Severini 2024-08-01T00:00:00Z https://doi.org/10.3390/v16081280 https://doaj.org/article/bada27fc9a744089921eb38b32e5efca EN eng MDPI AG https://www.mdpi.com/1999-4915/16/8/1280 https://doaj.org/toc/1999-4915 doi:10.3390/v16081280 1999-4915 https://doaj.org/article/bada27fc9a744089921eb38b32e5efca Viruses, Vol 16, Iss 8, p 1280 (2024) mumps virus whole genome sequencing Canadian mumps outbreaks Microbiology QR1-502 article 2024 ftdoajarticles https://doi.org/10.3390/v16081280 2024-09-02T15:34:37Z Despite the provision of a mumps vaccination program in Canada for over three decades, mumps has not reached elimination. Instead, a re-emergence has been observed in vaccinated populations, particularly in young adults. These outbreaks have been almost exclusively due to genotype G infections, a trend that has been seen in other countries with high mumps vaccination rates. To characterize mumps outbreaks in Canada, genomes from samples from Manitoba ( n = 209), Newfoundland ( n = 25), and Nova Scotia ( n = 48) were sequenced and analysed by Bayesian inference. Whole genome sequencing was shown to be highly discriminatory for outbreak investigations compared to traditional Sanger sequencing. The results showed that mumps virus genotype G most likely circulated endemically in Canada and between Canada and the US. Overall, this Canadian outbreak data from different provinces and ancestral strains demonstrates the benefits of molecular genomic data to better characterize mumps outbreaks, but also suggests genomics could further our understanding of the reasons for potential immune escape of mumps genotype G and evolution in highly vaccinated populations. With a possible endemic circulation of mumps genotype G and the remaining risk of new imported cases, increased surveillance and alternative vaccination strategies may be required for Canada to reach the current target for mumps or a future elimination status. Article in Journal/Newspaper Newfoundland Directory of Open Access Journals: DOAJ Articles Viruses 16 8 1280 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
mumps virus whole genome sequencing Canadian mumps outbreaks Microbiology QR1-502 |
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mumps virus whole genome sequencing Canadian mumps outbreaks Microbiology QR1-502 Jasmine Rae Frost Grace Eunchong Seo Kerry Dust Jared Bullard Peter Daley Jason J. LeBlanc Joanne Hiebert Elizabeth McLachlan Alberto Severini Genomic Characterization of Three Canadian Mumps Outbreaks Demonstrates Endemic Transmission in Canada |
topic_facet |
mumps virus whole genome sequencing Canadian mumps outbreaks Microbiology QR1-502 |
description |
Despite the provision of a mumps vaccination program in Canada for over three decades, mumps has not reached elimination. Instead, a re-emergence has been observed in vaccinated populations, particularly in young adults. These outbreaks have been almost exclusively due to genotype G infections, a trend that has been seen in other countries with high mumps vaccination rates. To characterize mumps outbreaks in Canada, genomes from samples from Manitoba ( n = 209), Newfoundland ( n = 25), and Nova Scotia ( n = 48) were sequenced and analysed by Bayesian inference. Whole genome sequencing was shown to be highly discriminatory for outbreak investigations compared to traditional Sanger sequencing. The results showed that mumps virus genotype G most likely circulated endemically in Canada and between Canada and the US. Overall, this Canadian outbreak data from different provinces and ancestral strains demonstrates the benefits of molecular genomic data to better characterize mumps outbreaks, but also suggests genomics could further our understanding of the reasons for potential immune escape of mumps genotype G and evolution in highly vaccinated populations. With a possible endemic circulation of mumps genotype G and the remaining risk of new imported cases, increased surveillance and alternative vaccination strategies may be required for Canada to reach the current target for mumps or a future elimination status. |
format |
Article in Journal/Newspaper |
author |
Jasmine Rae Frost Grace Eunchong Seo Kerry Dust Jared Bullard Peter Daley Jason J. LeBlanc Joanne Hiebert Elizabeth McLachlan Alberto Severini |
author_facet |
Jasmine Rae Frost Grace Eunchong Seo Kerry Dust Jared Bullard Peter Daley Jason J. LeBlanc Joanne Hiebert Elizabeth McLachlan Alberto Severini |
author_sort |
Jasmine Rae Frost |
title |
Genomic Characterization of Three Canadian Mumps Outbreaks Demonstrates Endemic Transmission in Canada |
title_short |
Genomic Characterization of Three Canadian Mumps Outbreaks Demonstrates Endemic Transmission in Canada |
title_full |
Genomic Characterization of Three Canadian Mumps Outbreaks Demonstrates Endemic Transmission in Canada |
title_fullStr |
Genomic Characterization of Three Canadian Mumps Outbreaks Demonstrates Endemic Transmission in Canada |
title_full_unstemmed |
Genomic Characterization of Three Canadian Mumps Outbreaks Demonstrates Endemic Transmission in Canada |
title_sort |
genomic characterization of three canadian mumps outbreaks demonstrates endemic transmission in canada |
publisher |
MDPI AG |
publishDate |
2024 |
url |
https://doi.org/10.3390/v16081280 https://doaj.org/article/bada27fc9a744089921eb38b32e5efca |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Viruses, Vol 16, Iss 8, p 1280 (2024) |
op_relation |
https://www.mdpi.com/1999-4915/16/8/1280 https://doaj.org/toc/1999-4915 doi:10.3390/v16081280 1999-4915 https://doaj.org/article/bada27fc9a744089921eb38b32e5efca |
op_doi |
https://doi.org/10.3390/v16081280 |
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Viruses |
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16 |
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8 |
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1280 |
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1810458559757942784 |