The global distribution of actinomycetoma and eumycetoma.
Background Mycetoma, a chronic infection of the skin and underlying structures, affects those with a close relationship to the land, often in resource-poor areas of the world. Whether caused by any one of a variety of fungus or bacteria, mycetoma causes significant disability and mortality. Acknowle...
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ftdoajarticles:oai:doaj.org/article:bad75792b963408d954441cc724bbd71 2023-05-15T15:09:18+02:00 The global distribution of actinomycetoma and eumycetoma. Darcy Emery David W Denning 2020-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008397 https://doaj.org/article/bad75792b963408d954441cc724bbd71 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008397 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008397 https://doaj.org/article/bad75792b963408d954441cc724bbd71 PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008397 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008397 2022-12-31T13:50:13Z Background Mycetoma, a chronic infection of the skin and underlying structures, affects those with a close relationship to the land, often in resource-poor areas of the world. Whether caused by any one of a variety of fungus or bacteria, mycetoma causes significant disability and mortality. Acknowledged as a neglected tropical disease (NTD) by the World Health Organization (WHO) in 2016, mycetoma is susceptible to being misunderstood, misdiagnosed, and mismanaged. In an effort to shift the balance in favor of recognition and effective treatment, sound epidemiological understanding is required. Methods and findings In this paper, a literature review of case reports and series (332 papers in total) is presented as three maps. We identified 19,494 cases dating from 1876 to 2019, with cases contracted in 102 countries. The first map shows where mycetoma has ever been reported, the second shows how many cases have been reported, and the third shows the ratio of eumycetoma (fungal) to actinomycetoma (bacterial). Most cases are found in Mexico, India, and Sudan, where mycetoma is studied rigorously. We identified emergence of new geographical loci, including the United States, Venezuela, Italy, China, and Australia. Notably, mycetoma is reported far outside the tropics. In the Americas, bacterial forms dominate, whereas, in Africa and Asia, the picture is more varied. Conclusions With better understanding of the epidemiology of mycetoma, more can be done to direct education, preventive measures, and treatment to at-risk areas, enabling a reduction in disease burden. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 9 e0008397 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Darcy Emery David W Denning The global distribution of actinomycetoma and eumycetoma. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Mycetoma, a chronic infection of the skin and underlying structures, affects those with a close relationship to the land, often in resource-poor areas of the world. Whether caused by any one of a variety of fungus or bacteria, mycetoma causes significant disability and mortality. Acknowledged as a neglected tropical disease (NTD) by the World Health Organization (WHO) in 2016, mycetoma is susceptible to being misunderstood, misdiagnosed, and mismanaged. In an effort to shift the balance in favor of recognition and effective treatment, sound epidemiological understanding is required. Methods and findings In this paper, a literature review of case reports and series (332 papers in total) is presented as three maps. We identified 19,494 cases dating from 1876 to 2019, with cases contracted in 102 countries. The first map shows where mycetoma has ever been reported, the second shows how many cases have been reported, and the third shows the ratio of eumycetoma (fungal) to actinomycetoma (bacterial). Most cases are found in Mexico, India, and Sudan, where mycetoma is studied rigorously. We identified emergence of new geographical loci, including the United States, Venezuela, Italy, China, and Australia. Notably, mycetoma is reported far outside the tropics. In the Americas, bacterial forms dominate, whereas, in Africa and Asia, the picture is more varied. Conclusions With better understanding of the epidemiology of mycetoma, more can be done to direct education, preventive measures, and treatment to at-risk areas, enabling a reduction in disease burden. |
format |
Article in Journal/Newspaper |
author |
Darcy Emery David W Denning |
author_facet |
Darcy Emery David W Denning |
author_sort |
Darcy Emery |
title |
The global distribution of actinomycetoma and eumycetoma. |
title_short |
The global distribution of actinomycetoma and eumycetoma. |
title_full |
The global distribution of actinomycetoma and eumycetoma. |
title_fullStr |
The global distribution of actinomycetoma and eumycetoma. |
title_full_unstemmed |
The global distribution of actinomycetoma and eumycetoma. |
title_sort |
global distribution of actinomycetoma and eumycetoma. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008397 https://doaj.org/article/bad75792b963408d954441cc724bbd71 |
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Arctic |
geographic_facet |
Arctic |
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Arctic |
genre_facet |
Arctic |
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PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008397 (2020) |
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https://doi.org/10.1371/journal.pntd.0008397 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008397 https://doaj.org/article/bad75792b963408d954441cc724bbd71 |
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https://doi.org/10.1371/journal.pntd.0008397 |
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