Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains Leishmaniose cutânea induzida pela Leishmania (Viannia) panamensis em linhagens de camundongos suscetíveis e resistentes
We studied the susceptibility to Leishmania (Viannia) panamensis in strains of mice. The C57BL/6 strain was resistant and showed self-controlled lesion at the injected foot pad. The BALB/c and DBA/2J strains were susceptible and showed a foot swelling that started day 20 post-infection and progresse...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
1995
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ftdoajarticles:oai:doaj.org/article:bab86b2396f441fc872afa94b9ebd488 2024-09-09T19:28:38+00:00 Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains Leishmaniose cutânea induzida pela Leishmania (Viannia) panamensis em linhagens de camundongos suscetíveis e resistentes H. Goto J. I. Rojas L. Sporrong P. de Carreira C. Sánchez A. Örn 1995-12-01T00:00:00Z https://doi.org/10.1590/S0036-46651995000600001 https://doaj.org/article/bab86b2396f441fc872afa94b9ebd488 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651995000600001 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651995000600001 0036-4665 1678-9946 https://doaj.org/article/bab86b2396f441fc872afa94b9ebd488 Revista do Instituto de Medicina Tropical de São Paulo, Vol 37, Iss 6, Pp 475-481 (1995) Cutaneous leishmaniasis Leishmania (Viannia) panamensis Experimental model Mice Immunology Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1995 ftdoajarticles https://doi.org/10.1590/S0036-46651995000600001 2024-08-05T17:49:30Z We studied the susceptibility to Leishmania (Viannia) panamensis in strains of mice. The C57BL/6 strain was resistant and showed self-controlled lesion at the injected foot pad. The BALB/c and DBA/2J strains were susceptible and showed a foot swelling that started day 20 post-infection and progressed to a tumour-like lesion in later period of observation. The CBA/HJ strain was found to be of intermediary resistance. In contrast to other known cutaneous leishmaniasis in mice, the lesion in L. (V.) panamensis-infected mice was restricted to the inoculation site in the skin. In addition, we studied the development of cellular response and antibodies against Leishmania antigen in BALB/c and C57BL/6 strains. The proliferative response of lymph node cells against L. (V.) panamensis antigen was biphasic in both strains. An initial response was seen on day 20, followed by a refractory period between 40 and 80 days and a second response around fourth month post-infection. The response in the latter period was higher in C57BL/6 strain than in BALB/c strain. BALB/c strain presented much higher anti-Leishmania antibody level than C57BL/6 strain. The model and the correlation of immunological variables and the course of the infection are discussed. Estudamos a susceptibilidade à Leishmania (Viannia) panamensis em linhagens de camundongos BALB/c, DBA/2J, CBA/HJ e C57BL/6. Os camundongos da linhagem C57BL/6 eram resistentes, apresentando lesões autolimitantes na pata. Os das linhagens BALB/c e DBA/2J eram suscetíveis, apresentando edema na pata, evidente aos 20 dias pós-infecção que progrediu para uma lesão tipo tumoral nas fases tardias. Os animais da linhagem CBA/HJ apresentaram resistência intermediária. Em contraste a outros modelos de leishmaniose cutânea murina, a lesão nos camundongos infectados pela L. (V.) panamensis mostrou ser restrita ao local de inoculação na pele. Estudamos também o desenvolvimento de resposta celular e anticorpos anti-Leishmania nas linhagens BALB/c c C57BL/6. A resposta proliferativa de células ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 37 6 475 481 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Cutaneous leishmaniasis Leishmania (Viannia) panamensis Experimental model Mice Immunology Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Cutaneous leishmaniasis Leishmania (Viannia) panamensis Experimental model Mice Immunology Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 H. Goto J. I. Rojas L. Sporrong P. de Carreira C. Sánchez A. Örn Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains Leishmaniose cutânea induzida pela Leishmania (Viannia) panamensis em linhagens de camundongos suscetíveis e resistentes |
topic_facet |
Cutaneous leishmaniasis Leishmania (Viannia) panamensis Experimental model Mice Immunology Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
We studied the susceptibility to Leishmania (Viannia) panamensis in strains of mice. The C57BL/6 strain was resistant and showed self-controlled lesion at the injected foot pad. The BALB/c and DBA/2J strains were susceptible and showed a foot swelling that started day 20 post-infection and progressed to a tumour-like lesion in later period of observation. The CBA/HJ strain was found to be of intermediary resistance. In contrast to other known cutaneous leishmaniasis in mice, the lesion in L. (V.) panamensis-infected mice was restricted to the inoculation site in the skin. In addition, we studied the development of cellular response and antibodies against Leishmania antigen in BALB/c and C57BL/6 strains. The proliferative response of lymph node cells against L. (V.) panamensis antigen was biphasic in both strains. An initial response was seen on day 20, followed by a refractory period between 40 and 80 days and a second response around fourth month post-infection. The response in the latter period was higher in C57BL/6 strain than in BALB/c strain. BALB/c strain presented much higher anti-Leishmania antibody level than C57BL/6 strain. The model and the correlation of immunological variables and the course of the infection are discussed. Estudamos a susceptibilidade à Leishmania (Viannia) panamensis em linhagens de camundongos BALB/c, DBA/2J, CBA/HJ e C57BL/6. Os camundongos da linhagem C57BL/6 eram resistentes, apresentando lesões autolimitantes na pata. Os das linhagens BALB/c e DBA/2J eram suscetíveis, apresentando edema na pata, evidente aos 20 dias pós-infecção que progrediu para uma lesão tipo tumoral nas fases tardias. Os animais da linhagem CBA/HJ apresentaram resistência intermediária. Em contraste a outros modelos de leishmaniose cutânea murina, a lesão nos camundongos infectados pela L. (V.) panamensis mostrou ser restrita ao local de inoculação na pele. Estudamos também o desenvolvimento de resposta celular e anticorpos anti-Leishmania nas linhagens BALB/c c C57BL/6. A resposta proliferativa de células ... |
format |
Article in Journal/Newspaper |
author |
H. Goto J. I. Rojas L. Sporrong P. de Carreira C. Sánchez A. Örn |
author_facet |
H. Goto J. I. Rojas L. Sporrong P. de Carreira C. Sánchez A. Örn |
author_sort |
H. Goto |
title |
Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains Leishmaniose cutânea induzida pela Leishmania (Viannia) panamensis em linhagens de camundongos suscetíveis e resistentes |
title_short |
Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains Leishmaniose cutânea induzida pela Leishmania (Viannia) panamensis em linhagens de camundongos suscetíveis e resistentes |
title_full |
Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains Leishmaniose cutânea induzida pela Leishmania (Viannia) panamensis em linhagens de camundongos suscetíveis e resistentes |
title_fullStr |
Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains Leishmaniose cutânea induzida pela Leishmania (Viannia) panamensis em linhagens de camundongos suscetíveis e resistentes |
title_full_unstemmed |
Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains Leishmaniose cutânea induzida pela Leishmania (Viannia) panamensis em linhagens de camundongos suscetíveis e resistentes |
title_sort |
leishmania (viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains leishmaniose cutânea induzida pela leishmania (viannia) panamensis em linhagens de camundongos suscetíveis e resistentes |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1995 |
url |
https://doi.org/10.1590/S0036-46651995000600001 https://doaj.org/article/bab86b2396f441fc872afa94b9ebd488 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 37, Iss 6, Pp 475-481 (1995) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651995000600001 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651995000600001 0036-4665 1678-9946 https://doaj.org/article/bab86b2396f441fc872afa94b9ebd488 |
op_doi |
https://doi.org/10.1590/S0036-46651995000600001 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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37 |
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6 |
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475 |
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481 |
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