Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains Leishmaniose cutânea induzida pela Leishmania (Viannia) panamensis em linhagens de camundongos suscetíveis e resistentes
We studied the susceptibility to Leishmania (Viannia) panamensis in strains of mice. The C57BL/6 strain was resistant and showed self-controlled lesion at the injected foot pad. The BALB/c and DBA/2J strains were susceptible and showed a foot swelling that started day 20 post-infection and progresse...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Universidade de São Paulo (USP)
1995
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Subjects: | |
Online Access: | https://doi.org/10.1590/S0036-46651995000600001 https://doaj.org/article/bab86b2396f441fc872afa94b9ebd488 |
Summary: | We studied the susceptibility to Leishmania (Viannia) panamensis in strains of mice. The C57BL/6 strain was resistant and showed self-controlled lesion at the injected foot pad. The BALB/c and DBA/2J strains were susceptible and showed a foot swelling that started day 20 post-infection and progressed to a tumour-like lesion in later period of observation. The CBA/HJ strain was found to be of intermediary resistance. In contrast to other known cutaneous leishmaniasis in mice, the lesion in L. (V.) panamensis-infected mice was restricted to the inoculation site in the skin. In addition, we studied the development of cellular response and antibodies against Leishmania antigen in BALB/c and C57BL/6 strains. The proliferative response of lymph node cells against L. (V.) panamensis antigen was biphasic in both strains. An initial response was seen on day 20, followed by a refractory period between 40 and 80 days and a second response around fourth month post-infection. The response in the latter period was higher in C57BL/6 strain than in BALB/c strain. BALB/c strain presented much higher anti-Leishmania antibody level than C57BL/6 strain. The model and the correlation of immunological variables and the course of the infection are discussed. Estudamos a susceptibilidade à Leishmania (Viannia) panamensis em linhagens de camundongos BALB/c, DBA/2J, CBA/HJ e C57BL/6. Os camundongos da linhagem C57BL/6 eram resistentes, apresentando lesões autolimitantes na pata. Os das linhagens BALB/c e DBA/2J eram suscetíveis, apresentando edema na pata, evidente aos 20 dias pós-infecção que progrediu para uma lesão tipo tumoral nas fases tardias. Os animais da linhagem CBA/HJ apresentaram resistência intermediária. Em contraste a outros modelos de leishmaniose cutânea murina, a lesão nos camundongos infectados pela L. (V.) panamensis mostrou ser restrita ao local de inoculação na pele. Estudamos também o desenvolvimento de resposta celular e anticorpos anti-Leishmania nas linhagens BALB/c c C57BL/6. A resposta proliferativa de células ... |
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