Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients
INTRODUCTION: In Brazil there is a large area of overlap of visceral leishmaniasis (VL) and HIV infection, which favored a increased incidence of coinfection Leishmania/HIV. METHODS: This study evaluated 65 consecutive patients with VL and their clinical response to treatment in two health care sett...
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ftdoajarticles:oai:doaj.org/article:ba9dde46554b456b86912d065e81430f 2023-05-15T15:05:12+02:00 Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients Guenael Freire de Souza Fernando Biscione Dirceu Bartolomeu Greco Ana Rabello 2012-04-01T00:00:00Z https://doi.org/10.1590/S0037-86822012000200001 https://doaj.org/article/ba9dde46554b456b86912d065e81430f EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000200001&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822012000200001 https://doaj.org/article/ba9dde46554b456b86912d065e81430f Revista da Sociedade Brasileira de Medicina Tropical, Vol 45, Iss 2, Pp 147-150 (2012) Leishmaniose visceral HIV Co-infecção Tratamento Arctic medicine. Tropical medicine RC955-962 article 2012 ftdoajarticles https://doi.org/10.1590/S0037-86822012000200001 2022-12-31T02:57:25Z INTRODUCTION: In Brazil there is a large area of overlap of visceral leishmaniasis (VL) and HIV infection, which favored a increased incidence of coinfection Leishmania/HIV. METHODS: This study evaluated 65 consecutive patients with VL and their clinical response to treatment in two health care settings in Belo Horizonte, Brazil. RESULTS: At baseline, the clinical picture was similar between both groups, although diarrhea and peripheral lymphadenomegaly were more frequent in HIV-infected subjects. HIV-positive patients had lower median blood lymphocyte counts (686/mm³ versus 948/mm³p = 0.004) and lower values of alanine aminotransferase (ALT) (48IU/L versus 75.6IU/L p = 0.016) than HIV-negative patients. HIV-positive status (hazard ratio = 0.423, p = 0.023) and anemia (HR = 0.205, p = 0.002) were independent negative predictors of complete clinical response following antileishmanial treatment initiation. CONCLUSIONS: This study reinforces that all patients with VL should be tested for HIV infection, regardless of their clinical picture. This practice would allow early recognition of coinfection with initiation of antiretroviral therapy and, possibly, reduction in treatment failure. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 45 2 147 150 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Leishmaniose visceral HIV Co-infecção Tratamento Arctic medicine. Tropical medicine RC955-962 |
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Leishmaniose visceral HIV Co-infecção Tratamento Arctic medicine. Tropical medicine RC955-962 Guenael Freire de Souza Fernando Biscione Dirceu Bartolomeu Greco Ana Rabello Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients |
topic_facet |
Leishmaniose visceral HIV Co-infecção Tratamento Arctic medicine. Tropical medicine RC955-962 |
description |
INTRODUCTION: In Brazil there is a large area of overlap of visceral leishmaniasis (VL) and HIV infection, which favored a increased incidence of coinfection Leishmania/HIV. METHODS: This study evaluated 65 consecutive patients with VL and their clinical response to treatment in two health care settings in Belo Horizonte, Brazil. RESULTS: At baseline, the clinical picture was similar between both groups, although diarrhea and peripheral lymphadenomegaly were more frequent in HIV-infected subjects. HIV-positive patients had lower median blood lymphocyte counts (686/mm³ versus 948/mm³p = 0.004) and lower values of alanine aminotransferase (ALT) (48IU/L versus 75.6IU/L p = 0.016) than HIV-negative patients. HIV-positive status (hazard ratio = 0.423, p = 0.023) and anemia (HR = 0.205, p = 0.002) were independent negative predictors of complete clinical response following antileishmanial treatment initiation. CONCLUSIONS: This study reinforces that all patients with VL should be tested for HIV infection, regardless of their clinical picture. This practice would allow early recognition of coinfection with initiation of antiretroviral therapy and, possibly, reduction in treatment failure. |
format |
Article in Journal/Newspaper |
author |
Guenael Freire de Souza Fernando Biscione Dirceu Bartolomeu Greco Ana Rabello |
author_facet |
Guenael Freire de Souza Fernando Biscione Dirceu Bartolomeu Greco Ana Rabello |
author_sort |
Guenael Freire de Souza |
title |
Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients |
title_short |
Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients |
title_full |
Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients |
title_fullStr |
Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients |
title_full_unstemmed |
Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients |
title_sort |
slow clinical improvement after treatment initiation in leishmania/hiv coinfected patients |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2012 |
url |
https://doi.org/10.1590/S0037-86822012000200001 https://doaj.org/article/ba9dde46554b456b86912d065e81430f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 45, Iss 2, Pp 147-150 (2012) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000200001&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822012000200001 https://doaj.org/article/ba9dde46554b456b86912d065e81430f |
op_doi |
https://doi.org/10.1590/S0037-86822012000200001 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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45 |
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2 |
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147 |
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150 |
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