Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats
Objective: To evaluate the neuroprotective effect of cryptotanshinone against cladribine-induced cognitive impairment in rats. Methods: Rats were administered with cladribine (1 mg/kg, p.o.) and cryptotanshinone (10 and 20 mg/kg, i.p.) for four weeks. Behavioral tests such as Morris water maze and e...
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Wolters Kluwer Medknow Publications
2023
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ftdoajarticles:oai:doaj.org/article:ba73380e75e743ff9038368a044f88f4 2024-09-09T19:25:54+00:00 Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats Khadga Raj Aran G D Gupta Shamsher Singh 2023-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.380561 https://doaj.org/article/ba73380e75e743ff9038368a044f88f4 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=7;spage=296;epage=305;aulast=Aran https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.380561 https://doaj.org/article/ba73380e75e743ff9038368a044f88f4 Asian Pacific Journal of Tropical Biomedicine, Vol 13, Iss 7, Pp 296-305 (2023) alzheimer's disease cladribine cryptotanshinone neurotransmitters neuroprotective proinflammatory cytokines cognitive deficit Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2023 ftdoajarticles https://doi.org/10.4103/2221-1691.380561 2024-08-05T17:49:19Z Objective: To evaluate the neuroprotective effect of cryptotanshinone against cladribine-induced cognitive impairment in rats. Methods: Rats were administered with cladribine (1 mg/kg, p.o.) and cryptotanshinone (10 and 20 mg/kg, i.p.) for four weeks. Behavioral tests such as Morris water maze and elevated plus maze were conducted to check memory impairment caused by cladribine. On day 29, all rats were sacrificed, and the brains were separated for estimation of neuroinflammatory factors, biochemical parameters, neurotransmitters, Aβ(1-42), blood-brain barrier permeability, nuclear factor erythroid 2-related factor 2 (Nrf2), and brain-derived neurotrophic factor (BDNF). Results: Treatment with cryptotanshinone dose-dependently enhanced spatial memory, improved the levels of neurotransmitter and antioxidant enzymes, and suppressed proinflammatory cytokine release. Cryptotanshinone also decreased Aβ(1-42) accumulation and increased the levels of Nrf2 and BDNF in the hippocampus. Additionally, the histopathological results showed that cryptotanshinone reduced cladribine-induced neuronal death in the hippocampus. Conclusions: Cryptotanshinone exhibits a promising neuroprotective effect against cladribine-induced cognitive impairment in preclinical studies, and may be a potential phytochemical for the treatment and management of cognitive impairment. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 13 7 296 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
alzheimer's disease cladribine cryptotanshinone neurotransmitters neuroprotective proinflammatory cytokines cognitive deficit Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
alzheimer's disease cladribine cryptotanshinone neurotransmitters neuroprotective proinflammatory cytokines cognitive deficit Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Khadga Raj Aran G D Gupta Shamsher Singh Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats |
topic_facet |
alzheimer's disease cladribine cryptotanshinone neurotransmitters neuroprotective proinflammatory cytokines cognitive deficit Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the neuroprotective effect of cryptotanshinone against cladribine-induced cognitive impairment in rats. Methods: Rats were administered with cladribine (1 mg/kg, p.o.) and cryptotanshinone (10 and 20 mg/kg, i.p.) for four weeks. Behavioral tests such as Morris water maze and elevated plus maze were conducted to check memory impairment caused by cladribine. On day 29, all rats were sacrificed, and the brains were separated for estimation of neuroinflammatory factors, biochemical parameters, neurotransmitters, Aβ(1-42), blood-brain barrier permeability, nuclear factor erythroid 2-related factor 2 (Nrf2), and brain-derived neurotrophic factor (BDNF). Results: Treatment with cryptotanshinone dose-dependently enhanced spatial memory, improved the levels of neurotransmitter and antioxidant enzymes, and suppressed proinflammatory cytokine release. Cryptotanshinone also decreased Aβ(1-42) accumulation and increased the levels of Nrf2 and BDNF in the hippocampus. Additionally, the histopathological results showed that cryptotanshinone reduced cladribine-induced neuronal death in the hippocampus. Conclusions: Cryptotanshinone exhibits a promising neuroprotective effect against cladribine-induced cognitive impairment in preclinical studies, and may be a potential phytochemical for the treatment and management of cognitive impairment. |
format |
Article in Journal/Newspaper |
author |
Khadga Raj Aran G D Gupta Shamsher Singh |
author_facet |
Khadga Raj Aran G D Gupta Shamsher Singh |
author_sort |
Khadga Raj Aran |
title |
Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats |
title_short |
Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats |
title_full |
Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats |
title_fullStr |
Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats |
title_full_unstemmed |
Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats |
title_sort |
cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2023 |
url |
https://doi.org/10.4103/2221-1691.380561 https://doaj.org/article/ba73380e75e743ff9038368a044f88f4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 13, Iss 7, Pp 296-305 (2023) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=7;spage=296;epage=305;aulast=Aran https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.380561 https://doaj.org/article/ba73380e75e743ff9038368a044f88f4 |
op_doi |
https://doi.org/10.4103/2221-1691.380561 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
13 |
container_issue |
7 |
container_start_page |
296 |
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1809895605394210816 |