Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Matheus Barbosa de Miranda, Adriene Siqueira de Melo, Mariana Silva Almeida, Silvia Martins Marinho, Wilson Oliveira Junior, Yara de Miranda Gomes
• Format: Article in Journal/Newspaper
• Language: English; Spanish; Portuguese
• Published: Sociedade Brasileira de Medicina Tropical (SBMT)
• Subjects: Chronic Chagas disease; Cardiomyopathy; Chemokine receptors; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0025-2017; https://doaj.org/article/ba3852cecaa5426d9cc6d97433889749

Abstract INTRODUCTION: Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets. METHODS: The ex vivo phenotypic expression of chemokine receptors CCR1, CCR3, CCR4, CCR5, CXCR2, CXCR3, CXCR4, and CXCR5 on the CD4+ and CD8+ T-cells of patients with chronic Chagas cardiomyopathy of varying severity was evaluated using flow cytometry. RESULTS: Differential expression of CD4+CCR3+ and CD8+CCR4+ T-cells was observed in patients with mild cardiac involvement compared, respectively, with patients with severe cardiac and asymptomatic forms of Chagas disease. CONCLUSIONS: These receptors are possibly involved in the pathogenesis of chronic Chagas cardiomyopathy.