Human platelets antigens influence the viral load of platelets after the interaction of the platelets with HCV and HIV in vitro

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Rejane Maria Tommasini Grotto, Natália Mirele Cantão, Juliana Lara Padovani, Lenice do Rosário de Souza, Giovanni Faria Silva, Adriana Camargo Ferrasi, Maria Inês de Moura Campos Pardini
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT)
• Subjects: Hepatitis C vírus; Human platelets antigen polymorphisms; Human immunodeficiency virus; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0105-2016; https://doaj.org/article/b9ded8ce5f2245c2a5ac393d46e41051

Abstract: INTRODUCTION: In this study, we evaluated hepatitis C virus (HCV) and human immunodeficiency virus (HIV) - platelet interactions in vitro as well as human platelets antigen (HPA) polymorphisms. METHODS: Platelets were obtained from 100 healthy HPA-genotyped volunteer donors and incubated with HIV or HCV. The viral load after in vitro exposure was detected. RESULTS: The viral load in the platelets after exposure to the virus was higher in the HIV exposure than in the HCV exposure. CONCLUSIONS: HIV-platelet ligation could be more efficient than HCV-platelet interaction. Further, the HPA-1b allele seems to influence the interaction of platelets with HCV.