Stratifying malaria receptivity in Bangladesh using archived rapid diagnostic tests
Abstract Background Surveillance of low-density infections and of exposure to vectors is crucial to understand where malaria elimination might be feasible, and where the risk of outbreaks is high. Archived rapid diagnostic tests (RDTs), used by national malaria control and elimination programs for c...
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ftdoajarticles:oai:doaj.org/article:b9daed68cb704611a9bc7269ae1fd913 2023-05-15T15:06:16+02:00 Stratifying malaria receptivity in Bangladesh using archived rapid diagnostic tests André Barembaye Sagna Mohammad Golam Kibria Shamsun Naher Shayla Islam M. M. Aktaruzzaman Mohammad Shafiul Alam Cristian Koepfli 2020-09-01T00:00:00Z https://doi.org/10.1186/s12936-020-03418-y https://doaj.org/article/b9daed68cb704611a9bc7269ae1fd913 EN eng BMC http://link.springer.com/article/10.1186/s12936-020-03418-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03418-y 1475-2875 https://doaj.org/article/b9daed68cb704611a9bc7269ae1fd913 Malaria Journal, Vol 19, Iss 1, Pp 1-7 (2020) Rapid diagnostic test Plasmodium falciparum Plasmodium vivax Malaria Transmission Surveillance Salivary biomarker Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-03418-y 2022-12-31T13:47:58Z Abstract Background Surveillance of low-density infections and of exposure to vectors is crucial to understand where malaria elimination might be feasible, and where the risk of outbreaks is high. Archived rapid diagnostic tests (RDTs), used by national malaria control and elimination programs for clinical diagnosis, present a valuable, yet rarely used resource for in-depth studies on malaria epidemiology. Methods 1022 RDTs from two sub-Districts in Bangladesh (Alikadam and Kamalganj) were screened by qPCR for low-density Plasmodium falciparum and Plasmodium vivax infections, and by ELISA for Anopheles salivary gland antibodies as a marker for exposure to vectors. Results Concordance between RDT and qPCR was moderate. qPCR detected 31/1022 infections compared to 36/1022 diagnosed by RDT. Exposure to Anopheles was significantly higher in Kamalganj despite low transmission, which could be explained by low bed net use. Conclusions Archived RDTs present a valuable source of antibodies for serological studies on exposure to vectors. In contrast, the benefit of screening archived RDTs to obtain a better estimate of clinical case numbers is moderate. Kamalganj could be prone to outbreaks. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 19 1 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Rapid diagnostic test Plasmodium falciparum Plasmodium vivax Malaria Transmission Surveillance Salivary biomarker Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Rapid diagnostic test Plasmodium falciparum Plasmodium vivax Malaria Transmission Surveillance Salivary biomarker Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 André Barembaye Sagna Mohammad Golam Kibria Shamsun Naher Shayla Islam M. M. Aktaruzzaman Mohammad Shafiul Alam Cristian Koepfli Stratifying malaria receptivity in Bangladesh using archived rapid diagnostic tests |
topic_facet |
Rapid diagnostic test Plasmodium falciparum Plasmodium vivax Malaria Transmission Surveillance Salivary biomarker Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Surveillance of low-density infections and of exposure to vectors is crucial to understand where malaria elimination might be feasible, and where the risk of outbreaks is high. Archived rapid diagnostic tests (RDTs), used by national malaria control and elimination programs for clinical diagnosis, present a valuable, yet rarely used resource for in-depth studies on malaria epidemiology. Methods 1022 RDTs from two sub-Districts in Bangladesh (Alikadam and Kamalganj) were screened by qPCR for low-density Plasmodium falciparum and Plasmodium vivax infections, and by ELISA for Anopheles salivary gland antibodies as a marker for exposure to vectors. Results Concordance between RDT and qPCR was moderate. qPCR detected 31/1022 infections compared to 36/1022 diagnosed by RDT. Exposure to Anopheles was significantly higher in Kamalganj despite low transmission, which could be explained by low bed net use. Conclusions Archived RDTs present a valuable source of antibodies for serological studies on exposure to vectors. In contrast, the benefit of screening archived RDTs to obtain a better estimate of clinical case numbers is moderate. Kamalganj could be prone to outbreaks. |
format |
Article in Journal/Newspaper |
author |
André Barembaye Sagna Mohammad Golam Kibria Shamsun Naher Shayla Islam M. M. Aktaruzzaman Mohammad Shafiul Alam Cristian Koepfli |
author_facet |
André Barembaye Sagna Mohammad Golam Kibria Shamsun Naher Shayla Islam M. M. Aktaruzzaman Mohammad Shafiul Alam Cristian Koepfli |
author_sort |
André Barembaye Sagna |
title |
Stratifying malaria receptivity in Bangladesh using archived rapid diagnostic tests |
title_short |
Stratifying malaria receptivity in Bangladesh using archived rapid diagnostic tests |
title_full |
Stratifying malaria receptivity in Bangladesh using archived rapid diagnostic tests |
title_fullStr |
Stratifying malaria receptivity in Bangladesh using archived rapid diagnostic tests |
title_full_unstemmed |
Stratifying malaria receptivity in Bangladesh using archived rapid diagnostic tests |
title_sort |
stratifying malaria receptivity in bangladesh using archived rapid diagnostic tests |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-03418-y https://doaj.org/article/b9daed68cb704611a9bc7269ae1fd913 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 19, Iss 1, Pp 1-7 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s12936-020-03418-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03418-y 1475-2875 https://doaj.org/article/b9daed68cb704611a9bc7269ae1fd913 |
op_doi |
https://doi.org/10.1186/s12936-020-03418-y |
container_title |
Malaria Journal |
container_volume |
19 |
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1 |
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1766337912569331712 |