An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS
Lead (Pb) is a metal toxicant of great public health concern. The present study investigated the applicability of the rat incisor in Pb exposure screening. The levels of lead in teeth (Pb-T) in the crown and root of incisors in laboratory Pb-exposed Sprague Dawley rats were quantified using inductiv...
Published in: | International Journal of Environmental Research and Public Health |
---|---|
Main Authors: | , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI AG
2021
|
Subjects: | |
Online Access: | https://doi.org/10.3390/ijerph18020767 https://doaj.org/article/b9ae3bc0d3cc4661917c6d8357bea25b |
id |
ftdoajarticles:oai:doaj.org/article:b9ae3bc0d3cc4661917c6d8357bea25b |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:b9ae3bc0d3cc4661917c6d8357bea25b 2023-05-15T18:05:33+02:00 An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS Andrew Kataba Shouta M. M. Nakayama Hokuto Nakata Haruya Toyomaki Yared B. Yohannes John Yabe Kaampwe Muzandu Golden Zyambo Ayano Kubota Takehisa Matsukawa Kazuhito Yokoyama Yoshinori Ikenaka Mayumi Ishizuka 2021-01-01T00:00:00Z https://doi.org/10.3390/ijerph18020767 https://doaj.org/article/b9ae3bc0d3cc4661917c6d8357bea25b EN eng MDPI AG https://www.mdpi.com/1660-4601/18/2/767 https://doaj.org/toc/1661-7827 https://doaj.org/toc/1660-4601 doi:10.3390/ijerph18020767 1660-4601 1661-7827 https://doaj.org/article/b9ae3bc0d3cc4661917c6d8357bea25b International Journal of Environmental Research and Public Health, Vol 18, Iss 767, p 767 (2021) lead incisor biomarker sentinel wild rodent Medicine R article 2021 ftdoajarticles https://doi.org/10.3390/ijerph18020767 2022-12-30T22:02:24Z Lead (Pb) is a metal toxicant of great public health concern. The present study investigated the applicability of the rat incisor in Pb exposure screening. The levels of lead in teeth (Pb-T) in the crown and root of incisors in laboratory Pb-exposed Sprague Dawley rats were quantified using inductively coupled plasma mass spectrometry (ICP-MS). The crown accumulated much Pb-T than the root of the Sprague Dawley rat incisor. The levels of lead in blood (Pb-B) were positively correlated with the Pb-T in the crown and root incisors of the Sprague Dawley rats. As an application of the Pb-T crown results in experimental rats, we subsequently analyzed the Pb-T in the crown incisors of Pb-exposed wild rats ( Rattus rattus ) sampled from residential sites within varying distances from an abandoned lead–zinc mine. The Pb-T accumulation in the crown of incisors of R. rattus rats decreased with increased distance away from the Pb–Zn mine. Furthermore, the Pb-T was strongly correlated ( r = 0.85) with the Pb levels in the blood. Laser ablation ICP-MS Pb-T mappings revealed a homogenous distribution of Pb in the incisor with an increased intensity of Pb-T localized in the tip of the incisor crown bearing an enamel surface in both Sprague Dawley and R. rattus rats. These findings suggest that Pb-T in the crown incisor may be reflective of the rat’s environmental habitat, thus a possible indicator of Pb exposure. Article in Journal/Newspaper Rattus rattus Directory of Open Access Journals: DOAJ Articles International Journal of Environmental Research and Public Health 18 2 767 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
lead incisor biomarker sentinel wild rodent Medicine R |
spellingShingle |
lead incisor biomarker sentinel wild rodent Medicine R Andrew Kataba Shouta M. M. Nakayama Hokuto Nakata Haruya Toyomaki Yared B. Yohannes John Yabe Kaampwe Muzandu Golden Zyambo Ayano Kubota Takehisa Matsukawa Kazuhito Yokoyama Yoshinori Ikenaka Mayumi Ishizuka An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS |
topic_facet |
lead incisor biomarker sentinel wild rodent Medicine R |
description |
Lead (Pb) is a metal toxicant of great public health concern. The present study investigated the applicability of the rat incisor in Pb exposure screening. The levels of lead in teeth (Pb-T) in the crown and root of incisors in laboratory Pb-exposed Sprague Dawley rats were quantified using inductively coupled plasma mass spectrometry (ICP-MS). The crown accumulated much Pb-T than the root of the Sprague Dawley rat incisor. The levels of lead in blood (Pb-B) were positively correlated with the Pb-T in the crown and root incisors of the Sprague Dawley rats. As an application of the Pb-T crown results in experimental rats, we subsequently analyzed the Pb-T in the crown incisors of Pb-exposed wild rats ( Rattus rattus ) sampled from residential sites within varying distances from an abandoned lead–zinc mine. The Pb-T accumulation in the crown of incisors of R. rattus rats decreased with increased distance away from the Pb–Zn mine. Furthermore, the Pb-T was strongly correlated ( r = 0.85) with the Pb levels in the blood. Laser ablation ICP-MS Pb-T mappings revealed a homogenous distribution of Pb in the incisor with an increased intensity of Pb-T localized in the tip of the incisor crown bearing an enamel surface in both Sprague Dawley and R. rattus rats. These findings suggest that Pb-T in the crown incisor may be reflective of the rat’s environmental habitat, thus a possible indicator of Pb exposure. |
format |
Article in Journal/Newspaper |
author |
Andrew Kataba Shouta M. M. Nakayama Hokuto Nakata Haruya Toyomaki Yared B. Yohannes John Yabe Kaampwe Muzandu Golden Zyambo Ayano Kubota Takehisa Matsukawa Kazuhito Yokoyama Yoshinori Ikenaka Mayumi Ishizuka |
author_facet |
Andrew Kataba Shouta M. M. Nakayama Hokuto Nakata Haruya Toyomaki Yared B. Yohannes John Yabe Kaampwe Muzandu Golden Zyambo Ayano Kubota Takehisa Matsukawa Kazuhito Yokoyama Yoshinori Ikenaka Mayumi Ishizuka |
author_sort |
Andrew Kataba |
title |
An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS |
title_short |
An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS |
title_full |
An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS |
title_fullStr |
An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS |
title_full_unstemmed |
An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS |
title_sort |
investigation of the wild rat crown incisor as an indicator of lead (pb) exposure using inductively couple plasma mass spectrometry (icp-ms) and laser ablation icp-ms |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doi.org/10.3390/ijerph18020767 https://doaj.org/article/b9ae3bc0d3cc4661917c6d8357bea25b |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
International Journal of Environmental Research and Public Health, Vol 18, Iss 767, p 767 (2021) |
op_relation |
https://www.mdpi.com/1660-4601/18/2/767 https://doaj.org/toc/1661-7827 https://doaj.org/toc/1660-4601 doi:10.3390/ijerph18020767 1660-4601 1661-7827 https://doaj.org/article/b9ae3bc0d3cc4661917c6d8357bea25b |
op_doi |
https://doi.org/10.3390/ijerph18020767 |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
18 |
container_issue |
2 |
container_start_page |
767 |
_version_ |
1766177028613079040 |