Targeted screening strategies to detect Trypanosoma cruzi infection in children.
Millions of people are infected with Trypanosoma cruzi, the causative agent of Chagas disease in Latin America. Anti-trypanosomal drug therapy can cure infected individuals, but treatment efficacy is highest early in infection. Vector control campaigns disrupt transmission of T. cruzi, but without t...
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ftdoajarticles:oai:doaj.org/article:b9a89be1a84e4a20ab71682f329c6186 2023-05-15T15:13:53+02:00 Targeted screening strategies to detect Trypanosoma cruzi infection in children. Michael Z Levy Vivian Kawai Natalie M Bowman Lance A Waller Lilia Cabrera Viviana V Pinedo-Cancino Amy E Seitz Frank J Steurer Juan G Cornejo del Carpio Eleazar Cordova-Benzaquen James H Maguire Robert H Gilman Caryn Bern 2007-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000103 https://doaj.org/article/b9a89be1a84e4a20ab71682f329c6186 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2154390?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000103 https://doaj.org/article/b9a89be1a84e4a20ab71682f329c6186 PLoS Neglected Tropical Diseases, Vol 1, Iss 3, p e103 (2007) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2007 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000103 2022-12-31T08:58:02Z Millions of people are infected with Trypanosoma cruzi, the causative agent of Chagas disease in Latin America. Anti-trypanosomal drug therapy can cure infected individuals, but treatment efficacy is highest early in infection. Vector control campaigns disrupt transmission of T. cruzi, but without timely diagnosis, children infected prior to vector control often miss the window of opportunity for effective chemotherapy.We performed a serological survey in children 2-18 years old living in a peri-urban community of Arequipa, Peru, and linked the results to entomologic, spatial and census data gathered during a vector control campaign. 23 of 433 (5.3% [95% CI 3.4-7.9]) children were confirmed seropositive for T. cruzi infection by two methods. Spatial analysis revealed that households with infected children were very tightly clustered within looser clusters of households with parasite-infected vectors. Bayesian hierarchical mixed models, which controlled for clustering of infection, showed that a child's risk of being seropositive increased by 20% per year of age and 4% per vector captured within the child's house. Receiver operator characteristic (ROC) plots of best-fit models suggest that more than 83% of infected children could be identified while testing only 22% of eligible children.We found evidence of spatially-focal vector-borne T. cruzi transmission in peri-urban Arequipa. Ongoing vector control campaigns, in addition to preventing further parasite transmission, facilitate the collection of data essential to identifying children at high risk of T. cruzi infection. Targeted screening strategies could make integration of diagnosis and treatment of children into Chagas disease control programs feasible in lower-resource settings. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 1 3 e103 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Michael Z Levy Vivian Kawai Natalie M Bowman Lance A Waller Lilia Cabrera Viviana V Pinedo-Cancino Amy E Seitz Frank J Steurer Juan G Cornejo del Carpio Eleazar Cordova-Benzaquen James H Maguire Robert H Gilman Caryn Bern Targeted screening strategies to detect Trypanosoma cruzi infection in children. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Millions of people are infected with Trypanosoma cruzi, the causative agent of Chagas disease in Latin America. Anti-trypanosomal drug therapy can cure infected individuals, but treatment efficacy is highest early in infection. Vector control campaigns disrupt transmission of T. cruzi, but without timely diagnosis, children infected prior to vector control often miss the window of opportunity for effective chemotherapy.We performed a serological survey in children 2-18 years old living in a peri-urban community of Arequipa, Peru, and linked the results to entomologic, spatial and census data gathered during a vector control campaign. 23 of 433 (5.3% [95% CI 3.4-7.9]) children were confirmed seropositive for T. cruzi infection by two methods. Spatial analysis revealed that households with infected children were very tightly clustered within looser clusters of households with parasite-infected vectors. Bayesian hierarchical mixed models, which controlled for clustering of infection, showed that a child's risk of being seropositive increased by 20% per year of age and 4% per vector captured within the child's house. Receiver operator characteristic (ROC) plots of best-fit models suggest that more than 83% of infected children could be identified while testing only 22% of eligible children.We found evidence of spatially-focal vector-borne T. cruzi transmission in peri-urban Arequipa. Ongoing vector control campaigns, in addition to preventing further parasite transmission, facilitate the collection of data essential to identifying children at high risk of T. cruzi infection. Targeted screening strategies could make integration of diagnosis and treatment of children into Chagas disease control programs feasible in lower-resource settings. |
format |
Article in Journal/Newspaper |
author |
Michael Z Levy Vivian Kawai Natalie M Bowman Lance A Waller Lilia Cabrera Viviana V Pinedo-Cancino Amy E Seitz Frank J Steurer Juan G Cornejo del Carpio Eleazar Cordova-Benzaquen James H Maguire Robert H Gilman Caryn Bern |
author_facet |
Michael Z Levy Vivian Kawai Natalie M Bowman Lance A Waller Lilia Cabrera Viviana V Pinedo-Cancino Amy E Seitz Frank J Steurer Juan G Cornejo del Carpio Eleazar Cordova-Benzaquen James H Maguire Robert H Gilman Caryn Bern |
author_sort |
Michael Z Levy |
title |
Targeted screening strategies to detect Trypanosoma cruzi infection in children. |
title_short |
Targeted screening strategies to detect Trypanosoma cruzi infection in children. |
title_full |
Targeted screening strategies to detect Trypanosoma cruzi infection in children. |
title_fullStr |
Targeted screening strategies to detect Trypanosoma cruzi infection in children. |
title_full_unstemmed |
Targeted screening strategies to detect Trypanosoma cruzi infection in children. |
title_sort |
targeted screening strategies to detect trypanosoma cruzi infection in children. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2007 |
url |
https://doi.org/10.1371/journal.pntd.0000103 https://doaj.org/article/b9a89be1a84e4a20ab71682f329c6186 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 1, Iss 3, p e103 (2007) |
op_relation |
http://europepmc.org/articles/PMC2154390?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000103 https://doaj.org/article/b9a89be1a84e4a20ab71682f329c6186 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000103 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
1 |
container_issue |
3 |
container_start_page |
e103 |
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1766344405715779584 |