Treatment of helminth co-infection in individuals with HIV-1: A systematic review of the literature.
The HIV-1 pandemic has disproportionately affected individuals in resource-constrained settings. It is important to determine if other prevalent infections affect the progression of HIV-1 in co-infected individuals in these settings. Some observational studies suggest that helminth infection may adv...
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ftdoajarticles:oai:doaj.org/article:b9706eafa4e640d18f003f2bd5d7e97d 2023-05-15T15:14:48+02:00 Treatment of helminth co-infection in individuals with HIV-1: A systematic review of the literature. Judd L Walson Grace John-Stewart 2007-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000102 https://doaj.org/article/b9706eafa4e640d18f003f2bd5d7e97d EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2154389?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000102 https://doaj.org/article/b9706eafa4e640d18f003f2bd5d7e97d PLoS Neglected Tropical Diseases, Vol 1, Iss 3, p e102 (2007) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2007 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000102 2022-12-31T15:04:25Z The HIV-1 pandemic has disproportionately affected individuals in resource-constrained settings. It is important to determine if other prevalent infections affect the progression of HIV-1 in co-infected individuals in these settings. Some observational studies suggest that helminth infection may adversely affect HIV-1 progression. We sought to evaluate existing evidence on whether treatment of helminth infection impacts HIV-1 progression.This review was conducted using the HIV/AIDS Cochrane Review Group (CRG) search strategy and guidelines. Published and unpublished studies were obtained from The Cochrane Library (Issue 3, 2006), MEDLINE (November 2006), EMBASE (November 2006), CENTRAL (July 2006), and AIDSEARCH (August 2006). Databases listing conference abstracts and scanned reference lists were searched, and authors of included studies were contacted. Data regarding changes in CD4 count, HIV-1 RNA levels, clinical staging and/or mortality were extracted and compared between helminth-treated and helminth-untreated or helminth-uninfected individuals.Of 6,384 abstracts identified, 15 met criteria for potential inclusion, of which 5 were eligible for inclusion. In the single randomized controlled trial (RCT) identified, HIV-1 and schistosomiasis co-infected individuals receiving treatment for schistosomiasis had a significantly lower change in plasma HIV-1 RNA over three months (-0.001 log(10) copies/mL) compared to those receiving no treatment (+0.21 log(10) copies/mL), (p = 0.03). Four observational studies met inclusion criteria, and all of these suggested a possible beneficial effect of helminth eradication on plasma HIV-1 RNA levels when compared to plasma HIV-1 RNA changes prior to helminth treatment or to helminth-uninfected or persistently helminth-infected individuals. The follow-up duration in these studies ranged from three to six months. The reported magnitude of effect on HIV-1 RNA was variable, ranging from 0.07-1.05 log(10) copies/mL. None of the included studies showed a significant benefit of ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 1 3 e102 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Judd L Walson Grace John-Stewart Treatment of helminth co-infection in individuals with HIV-1: A systematic review of the literature. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The HIV-1 pandemic has disproportionately affected individuals in resource-constrained settings. It is important to determine if other prevalent infections affect the progression of HIV-1 in co-infected individuals in these settings. Some observational studies suggest that helminth infection may adversely affect HIV-1 progression. We sought to evaluate existing evidence on whether treatment of helminth infection impacts HIV-1 progression.This review was conducted using the HIV/AIDS Cochrane Review Group (CRG) search strategy and guidelines. Published and unpublished studies were obtained from The Cochrane Library (Issue 3, 2006), MEDLINE (November 2006), EMBASE (November 2006), CENTRAL (July 2006), and AIDSEARCH (August 2006). Databases listing conference abstracts and scanned reference lists were searched, and authors of included studies were contacted. Data regarding changes in CD4 count, HIV-1 RNA levels, clinical staging and/or mortality were extracted and compared between helminth-treated and helminth-untreated or helminth-uninfected individuals.Of 6,384 abstracts identified, 15 met criteria for potential inclusion, of which 5 were eligible for inclusion. In the single randomized controlled trial (RCT) identified, HIV-1 and schistosomiasis co-infected individuals receiving treatment for schistosomiasis had a significantly lower change in plasma HIV-1 RNA over three months (-0.001 log(10) copies/mL) compared to those receiving no treatment (+0.21 log(10) copies/mL), (p = 0.03). Four observational studies met inclusion criteria, and all of these suggested a possible beneficial effect of helminth eradication on plasma HIV-1 RNA levels when compared to plasma HIV-1 RNA changes prior to helminth treatment or to helminth-uninfected or persistently helminth-infected individuals. The follow-up duration in these studies ranged from three to six months. The reported magnitude of effect on HIV-1 RNA was variable, ranging from 0.07-1.05 log(10) copies/mL. None of the included studies showed a significant benefit of ... |
format |
Article in Journal/Newspaper |
author |
Judd L Walson Grace John-Stewart |
author_facet |
Judd L Walson Grace John-Stewart |
author_sort |
Judd L Walson |
title |
Treatment of helminth co-infection in individuals with HIV-1: A systematic review of the literature. |
title_short |
Treatment of helminth co-infection in individuals with HIV-1: A systematic review of the literature. |
title_full |
Treatment of helminth co-infection in individuals with HIV-1: A systematic review of the literature. |
title_fullStr |
Treatment of helminth co-infection in individuals with HIV-1: A systematic review of the literature. |
title_full_unstemmed |
Treatment of helminth co-infection in individuals with HIV-1: A systematic review of the literature. |
title_sort |
treatment of helminth co-infection in individuals with hiv-1: a systematic review of the literature. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2007 |
url |
https://doi.org/10.1371/journal.pntd.0000102 https://doaj.org/article/b9706eafa4e640d18f003f2bd5d7e97d |
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Arctic |
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Arctic |
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Arctic |
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Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 1, Iss 3, p e102 (2007) |
op_relation |
http://europepmc.org/articles/PMC2154389?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000102 https://doaj.org/article/b9706eafa4e640d18f003f2bd5d7e97d |
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https://doi.org/10.1371/journal.pntd.0000102 |
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PLoS Neglected Tropical Diseases |
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e102 |
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