Mefloquine--an aminoalcohol with promising antischistosomal properties in mice.
BACKGROUND: The treatment and control of schistosomiasis, an often neglected tropical disease that exacerbates poverty, depends on a single drug, praziquantel. The large-scale use of praziquantel might select for drug-resistant parasites, hence there is a need to develop new antischistosomal compoun...
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ftdoajarticles:oai:doaj.org/article:b96a5e016a4a4325965f736d274cf6ef 2023-05-15T15:10:16+02:00 Mefloquine--an aminoalcohol with promising antischistosomal properties in mice. Jennifer Keiser Jacques Chollet Shu-Hua Xiao Jin-Yan Mei Pei-Ying Jiao Jürg Utzinger Marcel Tanner 2009-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000350 https://doaj.org/article/b96a5e016a4a4325965f736d274cf6ef EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2600813?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0000350 https://doaj.org/article/b96a5e016a4a4325965f736d274cf6ef PLoS Neglected Tropical Diseases, Vol 3, Iss 1, p e350 (2009) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2009 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000350 2022-12-31T08:30:05Z BACKGROUND: The treatment and control of schistosomiasis, an often neglected tropical disease that exacerbates poverty, depends on a single drug, praziquantel. The large-scale use of praziquantel might select for drug-resistant parasites, hence there is a need to develop new antischistosomal compounds. Here, we report that the antimalarial drug mefloquine possesses promising antischistosomal properties in mice. METHODOLOGY/PRINCIPAL FINDINGS: A single dose of mefloquine (200 or 400 mg/kg) administered orally to mice infected with adult Schistosoma mansoni or adult S. japonicum resulted in high or complete total and female worm burden reductions (72.3%-100%). Importantly, high worm burden reductions were also observed for young developing stages of S. mansoni and S. japonicum harbored in the mouse. Both mefloquine erythro-enantiomers resulted in high and comparable total and female worm burden reductions when given to mice with either a sub-patent or patent S. mansoni infection. CONCLUSIONS/SIGNIFICANCE: Our findings hold promise for the development of a novel antischistosomal drug based on an aminoalcohol functionality. Further in vitro and in vivo studies have been launched to elucidate the possible mechanism of action and to study the effect of mefloquine on S. haematobium and other trematodes. It will be interesting to investigate whether mefloquine, which is widely and effectively used for the treatment of malaria, has an impact on schistosomiasis in areas where both malaria and schistosomiasis co-exist. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 3 1 e350 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jennifer Keiser Jacques Chollet Shu-Hua Xiao Jin-Yan Mei Pei-Ying Jiao Jürg Utzinger Marcel Tanner Mefloquine--an aminoalcohol with promising antischistosomal properties in mice. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: The treatment and control of schistosomiasis, an often neglected tropical disease that exacerbates poverty, depends on a single drug, praziquantel. The large-scale use of praziquantel might select for drug-resistant parasites, hence there is a need to develop new antischistosomal compounds. Here, we report that the antimalarial drug mefloquine possesses promising antischistosomal properties in mice. METHODOLOGY/PRINCIPAL FINDINGS: A single dose of mefloquine (200 or 400 mg/kg) administered orally to mice infected with adult Schistosoma mansoni or adult S. japonicum resulted in high or complete total and female worm burden reductions (72.3%-100%). Importantly, high worm burden reductions were also observed for young developing stages of S. mansoni and S. japonicum harbored in the mouse. Both mefloquine erythro-enantiomers resulted in high and comparable total and female worm burden reductions when given to mice with either a sub-patent or patent S. mansoni infection. CONCLUSIONS/SIGNIFICANCE: Our findings hold promise for the development of a novel antischistosomal drug based on an aminoalcohol functionality. Further in vitro and in vivo studies have been launched to elucidate the possible mechanism of action and to study the effect of mefloquine on S. haematobium and other trematodes. It will be interesting to investigate whether mefloquine, which is widely and effectively used for the treatment of malaria, has an impact on schistosomiasis in areas where both malaria and schistosomiasis co-exist. |
format |
Article in Journal/Newspaper |
author |
Jennifer Keiser Jacques Chollet Shu-Hua Xiao Jin-Yan Mei Pei-Ying Jiao Jürg Utzinger Marcel Tanner |
author_facet |
Jennifer Keiser Jacques Chollet Shu-Hua Xiao Jin-Yan Mei Pei-Ying Jiao Jürg Utzinger Marcel Tanner |
author_sort |
Jennifer Keiser |
title |
Mefloquine--an aminoalcohol with promising antischistosomal properties in mice. |
title_short |
Mefloquine--an aminoalcohol with promising antischistosomal properties in mice. |
title_full |
Mefloquine--an aminoalcohol with promising antischistosomal properties in mice. |
title_fullStr |
Mefloquine--an aminoalcohol with promising antischistosomal properties in mice. |
title_full_unstemmed |
Mefloquine--an aminoalcohol with promising antischistosomal properties in mice. |
title_sort |
mefloquine--an aminoalcohol with promising antischistosomal properties in mice. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2009 |
url |
https://doi.org/10.1371/journal.pntd.0000350 https://doaj.org/article/b96a5e016a4a4325965f736d274cf6ef |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 3, Iss 1, p e350 (2009) |
op_relation |
http://europepmc.org/articles/PMC2600813?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0000350 https://doaj.org/article/b96a5e016a4a4325965f736d274cf6ef |
op_doi |
https://doi.org/10.1371/journal.pntd.0000350 |
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PLoS Neglected Tropical Diseases |
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3 |
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1 |
container_start_page |
e350 |
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