Systematic neonatal screening for congenital Chagas disease in Northeast Brazil: prevalence of Trypanosoma cruzi infection in the Southern region of Sergipe
Abstract INTRODUCTION: Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, being one of the leading causes of morbidity and mortality in the Americas with an estimated six to seven million infected people worldwide. In Brazil, the improvement in vector control and blood donor scr...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Sociedade Brasileira de Medicina Tropical (SBMT)
|
Subjects: | |
Online Access: | https://doi.org/10.1590/0037-8682-0024-2018 https://doaj.org/article/b9579cdba6e94dff8499959aa41e10ab |
id |
ftdoajarticles:oai:doaj.org/article:b9579cdba6e94dff8499959aa41e10ab |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:b9579cdba6e94dff8499959aa41e10ab 2023-05-15T15:11:08+02:00 Systematic neonatal screening for congenital Chagas disease in Northeast Brazil: prevalence of Trypanosoma cruzi infection in the Southern region of Sergipe Fábia Regina dos Santos Diana Matos Euzébio Genilde Gomes de Oliveira Mayra Souza Chagas Alex Ricardo Ferreira Lídia Almeida Mendonça Dalmo Correia Angela Maria da Silva https://doi.org/10.1590/0037-8682-0024-2018 https://doaj.org/article/b9579cdba6e94dff8499959aa41e10ab EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000300310&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0024-2018 https://doaj.org/article/b9579cdba6e94dff8499959aa41e10ab Revista da Sociedade Brasileira de Medicina Tropical, Vol 51, Iss 3, Pp 310-317 Chagas disease Epidemiology Neonatal screening Trypanosoma cruzi Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0024-2018 2022-12-30T21:38:28Z Abstract INTRODUCTION: Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, being one of the leading causes of morbidity and mortality in the Americas with an estimated six to seven million infected people worldwide. In Brazil, the improvement in vector control and blood donor screening has evidenced the important epidemiological role of congenital transmission of Chagas disease. METHODS: A serological survey for Chagas disease was performed in 3,952 newborns in the southern region of Sergipe using paper filter disks of dried blood samples. The newborns were screened using the Sergipe State Neonatal Screening Program between July 2015 and July 2016, and 3,749 and 750 blood samples were obtained for the IgG enzyme-linked immunosorbent assay and indirect immunofluorescence assay, respectively. In addition, mothers of the children who presented initial reagent serology were examined. RESULTS: Among 3,749 blood samples, samples of two children were positive for the enzyme-linked immunosorbent assay; however, their confirmation test results were negative, suggesting passive transfer of the mother’s antibody. One puerpera was identified with Chagas disease, with a prevalence of 0.02%. CONCLUSIONS: Congenital Chagas disease was not observed in newborns in the Southern region of Sergipe. However, Chagas disease was observed in women of reproductive age. Therefore, effective measurements for monitoring and systematic evaluation should be conducted. The Neonatal Screening Program proved to be an effective public health strategy for the prevention and control of Chagas disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 51 3 310 317 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Chagas disease Epidemiology Neonatal screening Trypanosoma cruzi Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Chagas disease Epidemiology Neonatal screening Trypanosoma cruzi Arctic medicine. Tropical medicine RC955-962 Fábia Regina dos Santos Diana Matos Euzébio Genilde Gomes de Oliveira Mayra Souza Chagas Alex Ricardo Ferreira Lídia Almeida Mendonça Dalmo Correia Angela Maria da Silva Systematic neonatal screening for congenital Chagas disease in Northeast Brazil: prevalence of Trypanosoma cruzi infection in the Southern region of Sergipe |
topic_facet |
Chagas disease Epidemiology Neonatal screening Trypanosoma cruzi Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION: Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, being one of the leading causes of morbidity and mortality in the Americas with an estimated six to seven million infected people worldwide. In Brazil, the improvement in vector control and blood donor screening has evidenced the important epidemiological role of congenital transmission of Chagas disease. METHODS: A serological survey for Chagas disease was performed in 3,952 newborns in the southern region of Sergipe using paper filter disks of dried blood samples. The newborns were screened using the Sergipe State Neonatal Screening Program between July 2015 and July 2016, and 3,749 and 750 blood samples were obtained for the IgG enzyme-linked immunosorbent assay and indirect immunofluorescence assay, respectively. In addition, mothers of the children who presented initial reagent serology were examined. RESULTS: Among 3,749 blood samples, samples of two children were positive for the enzyme-linked immunosorbent assay; however, their confirmation test results were negative, suggesting passive transfer of the mother’s antibody. One puerpera was identified with Chagas disease, with a prevalence of 0.02%. CONCLUSIONS: Congenital Chagas disease was not observed in newborns in the Southern region of Sergipe. However, Chagas disease was observed in women of reproductive age. Therefore, effective measurements for monitoring and systematic evaluation should be conducted. The Neonatal Screening Program proved to be an effective public health strategy for the prevention and control of Chagas disease. |
format |
Article in Journal/Newspaper |
author |
Fábia Regina dos Santos Diana Matos Euzébio Genilde Gomes de Oliveira Mayra Souza Chagas Alex Ricardo Ferreira Lídia Almeida Mendonça Dalmo Correia Angela Maria da Silva |
author_facet |
Fábia Regina dos Santos Diana Matos Euzébio Genilde Gomes de Oliveira Mayra Souza Chagas Alex Ricardo Ferreira Lídia Almeida Mendonça Dalmo Correia Angela Maria da Silva |
author_sort |
Fábia Regina dos Santos |
title |
Systematic neonatal screening for congenital Chagas disease in Northeast Brazil: prevalence of Trypanosoma cruzi infection in the Southern region of Sergipe |
title_short |
Systematic neonatal screening for congenital Chagas disease in Northeast Brazil: prevalence of Trypanosoma cruzi infection in the Southern region of Sergipe |
title_full |
Systematic neonatal screening for congenital Chagas disease in Northeast Brazil: prevalence of Trypanosoma cruzi infection in the Southern region of Sergipe |
title_fullStr |
Systematic neonatal screening for congenital Chagas disease in Northeast Brazil: prevalence of Trypanosoma cruzi infection in the Southern region of Sergipe |
title_full_unstemmed |
Systematic neonatal screening for congenital Chagas disease in Northeast Brazil: prevalence of Trypanosoma cruzi infection in the Southern region of Sergipe |
title_sort |
systematic neonatal screening for congenital chagas disease in northeast brazil: prevalence of trypanosoma cruzi infection in the southern region of sergipe |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0024-2018 https://doaj.org/article/b9579cdba6e94dff8499959aa41e10ab |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 51, Iss 3, Pp 310-317 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000300310&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0024-2018 https://doaj.org/article/b9579cdba6e94dff8499959aa41e10ab |
op_doi |
https://doi.org/10.1590/0037-8682-0024-2018 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
51 |
container_issue |
3 |
container_start_page |
310 |
op_container_end_page |
317 |
_version_ |
1766342034787926016 |