Diagnostic accuracy of antigen detection in urine and molecular assays testing in different clinical samples for the diagnosis of progressive disseminated histoplasmosis in patients living with HIV/AIDS: A prospective multicenter study in Mexico.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Areli Martínez-Gamboa, María Dolores Niembro-Ortega, Pedro Torres-González, Janeth Santiago-Cruz, Nancy Guadalupe Velázquez-Zavala, Andrea Rangel-Cordero, Brenda Crabtree-Ramírez, Armando Gamboa-Domínguez, Edgardo Reyes-Gutiérrez, Gustavo Reyes-Terán, Víctor Hugo Lozano-Fernandez, Víctor Hugo Ahumada-Topete, Pedro Martínez-Ayala, Marisol Manríquez-Reyes, Juan Pablo Ramírez-Hinojosa, Patricia Rodríguez-Zulueta, Christian Hernández-León, Jesús Ruíz-Quiñones, Norma Eréndira Rivera-Martínez, Alberto Chaparro-Sánchez, Jaime Andrade-Villanueva, Luz Alicia González-Hernández, Sofia Cruz-Martínez, Oscar Flores-Barrientos, Jesús Enrique Gaytán-Martínez, Martín Magaña-Aquino, Axel Cervantes-Sánchez, Antonio Olivas-Martínez, Javier Araujo-Meléndez, María Del Rocío Reyes-Montes, Esperanza Duarte-Escalante, María Guadalupe Frías-De León, José Antonio Ramírez, María Lucia Taylor, Alfredo Ponce de León-Garduño, José Sifuentes-Osornio
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2021
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Eia
• Online Access: https://doi.org/10.1371/journal.pntd.0009215; https://doaj.org/article/b93579871f1a49d1a1f7166df3e2a1d2

Background The progressive disseminated histoplasmosis (PDH) has been associated with severe disease and high risk of death among people living with HIV (PLWHIV). Therefore, the purpose of this multicenter, prospective, double-blinded study done in ten Mexican hospitals was to determine the diagnost...