Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis.
By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits.This review was prospectively registered in the PROSPERO database (CRD42016...
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ftdoajarticles:oai:doaj.org/article:b9338914334d46aeb26bae9f1701a131 2023-05-15T15:13:07+02:00 Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis. Amara E Ezeamama Amaya L Bustinduy Allan K Nkwata Leonardo Martinez Noel Pabalan Michael J Boivin Charles H King 2018-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005524 https://doaj.org/article/b9338914334d46aeb26bae9f1701a131 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5766129?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005524 https://doaj.org/article/b9338914334d46aeb26bae9f1701a131 PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0005524 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005524 2022-12-31T02:59:57Z By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits.This review was prospectively registered in the PROSPERO database (CRD42016040052). Medline, Biosis, and Web of Science were searched for studies published before August 2016 that evaluated associations between Schistosoma infection and cognitive or educational outcomes. Cognitive function was defined in four domains-learning, memory, reaction time, and innate intelligence. Educational outcome measures were defined as attendance and scholastic achievement. Risk of bias (ROB) was evaluated using the Newcastle-Ottawa quality assessment scale. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare cognitive and educational measures for Schistosoma infected /not dewormed vs. uninfected/dewormed children. Sensitivity analyses by study design, ROB, and sequential exclusion of individual studies were implemented. Thirty studies from 14 countries, including 38,992 SAC between 5-19 years old, were identified. Compared to uninfected children and children dewormed with praziquantel, the presence of Schistosoma infection and/or non-dewormed status was associated with deficits in school attendance (SMD = -0.36, 95%CI: -0.60, -0.12), scholastic achievement (SMD = -0.58, 95%CI: -0.96, -0.20), learning (SMD = -0.39, 95%CI: -0.70, -0.09) and memory (SMD = -0.28, 95%CI: -0.52, -0.04) tests. By contrast, Schistosoma-infected/non-dewormed and uninfected/dewormed children were similar with respect to performance in tests of reaction time (SMD = -0.06, 95%CI: -0.42, 0.30) and intelligence (SMD = -0.25, 95%CI: -0.57, 0.06). Schistosoma infection-associated deficits in educational measures were robust among observational studies, but not among interventional studies. The significance of infection-associated deficits in scholastic achievement was sensitive to ROB. ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 1 e0005524 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Amara E Ezeamama Amaya L Bustinduy Allan K Nkwata Leonardo Martinez Noel Pabalan Michael J Boivin Charles H King Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits.This review was prospectively registered in the PROSPERO database (CRD42016040052). Medline, Biosis, and Web of Science were searched for studies published before August 2016 that evaluated associations between Schistosoma infection and cognitive or educational outcomes. Cognitive function was defined in four domains-learning, memory, reaction time, and innate intelligence. Educational outcome measures were defined as attendance and scholastic achievement. Risk of bias (ROB) was evaluated using the Newcastle-Ottawa quality assessment scale. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare cognitive and educational measures for Schistosoma infected /not dewormed vs. uninfected/dewormed children. Sensitivity analyses by study design, ROB, and sequential exclusion of individual studies were implemented. Thirty studies from 14 countries, including 38,992 SAC between 5-19 years old, were identified. Compared to uninfected children and children dewormed with praziquantel, the presence of Schistosoma infection and/or non-dewormed status was associated with deficits in school attendance (SMD = -0.36, 95%CI: -0.60, -0.12), scholastic achievement (SMD = -0.58, 95%CI: -0.96, -0.20), learning (SMD = -0.39, 95%CI: -0.70, -0.09) and memory (SMD = -0.28, 95%CI: -0.52, -0.04) tests. By contrast, Schistosoma-infected/non-dewormed and uninfected/dewormed children were similar with respect to performance in tests of reaction time (SMD = -0.06, 95%CI: -0.42, 0.30) and intelligence (SMD = -0.25, 95%CI: -0.57, 0.06). Schistosoma infection-associated deficits in educational measures were robust among observational studies, but not among interventional studies. The significance of infection-associated deficits in scholastic achievement was sensitive to ROB. ... |
format |
Article in Journal/Newspaper |
author |
Amara E Ezeamama Amaya L Bustinduy Allan K Nkwata Leonardo Martinez Noel Pabalan Michael J Boivin Charles H King |
author_facet |
Amara E Ezeamama Amaya L Bustinduy Allan K Nkwata Leonardo Martinez Noel Pabalan Michael J Boivin Charles H King |
author_sort |
Amara E Ezeamama |
title |
Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis. |
title_short |
Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis. |
title_full |
Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis. |
title_fullStr |
Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis. |
title_full_unstemmed |
Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis. |
title_sort |
cognitive deficits and educational loss in children with schistosome infection-a systematic review and meta-analysis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0005524 https://doaj.org/article/b9338914334d46aeb26bae9f1701a131 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0005524 (2018) |
op_relation |
http://europepmc.org/articles/PMC5766129?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005524 https://doaj.org/article/b9338914334d46aeb26bae9f1701a131 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005524 |
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PLOS Neglected Tropical Diseases |
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12 |
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1 |
container_start_page |
e0005524 |
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1766343715841900544 |