Effect of Peptides from Alaska Pollock on Intestinal Mucosal Immunity Function and Purification of Active Fragments
The intestinal mucosal barrier plays an important role in systemic immune functions. This study aimed to find the mechanism of peptide from Alaska Pollock (APP) on intestinal mucosal immunity in mice induced by cyclophosphamide (Cy). Cy-induced decreases of body weight and index of immune organ were...
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ftdoajarticles:oai:doaj.org/article:b923eb549a184d55a588def0d0abe738 2023-05-15T13:09:19+02:00 Effect of Peptides from Alaska Pollock on Intestinal Mucosal Immunity Function and Purification of Active Fragments Qiqi Li Shikai Wang Supanooch Poungchawanwong Hu Hou 2019-10-01T00:00:00Z https://doi.org/10.3390/nu11102517 https://doaj.org/article/b923eb549a184d55a588def0d0abe738 EN eng MDPI AG https://www.mdpi.com/2072-6643/11/10/2517 https://doaj.org/toc/2072-6643 2072-6643 doi:10.3390/nu11102517 https://doaj.org/article/b923eb549a184d55a588def0d0abe738 Nutrients, Vol 11, Iss 10, p 2517 (2019) alaska pollock peptide intestinal mucosal immune siga purification Nutrition. Foods and food supply TX341-641 article 2019 ftdoajarticles https://doi.org/10.3390/nu11102517 2022-12-31T08:31:29Z The intestinal mucosal barrier plays an important role in systemic immune functions. This study aimed to find the mechanism of peptide from Alaska Pollock (APP) on intestinal mucosal immunity in mice induced by cyclophosphamide (Cy). Cy-induced decreases of body weight and index of immune organ were significantly improved by APP as compared with Cy group ( p < 0.05). APP could promote the secretion of SIgA and IgA on intestinal mucosa ( p < 0.05) and mainly had an impact on the final differentiation of IgA + B cell, thereby promoting the secretion of plasma cells, which can be corroborated by the increases of IL-6 and IL-10 ( p < 0.05). APP with high immune activity was separated and two peptides were purified and identified as Gly−Val−Ile−Lys and Ala−Cys−Asn−Gly−Arg. Therefore, APP can be considered as beneficial ingredients to protect the intestinal barrier disruption induced by Cy. Article in Journal/Newspaper alaska pollock Alaska Directory of Open Access Journals: DOAJ Articles Nutrients 11 10 2517 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
alaska pollock peptide intestinal mucosal immune siga purification Nutrition. Foods and food supply TX341-641 |
spellingShingle |
alaska pollock peptide intestinal mucosal immune siga purification Nutrition. Foods and food supply TX341-641 Qiqi Li Shikai Wang Supanooch Poungchawanwong Hu Hou Effect of Peptides from Alaska Pollock on Intestinal Mucosal Immunity Function and Purification of Active Fragments |
topic_facet |
alaska pollock peptide intestinal mucosal immune siga purification Nutrition. Foods and food supply TX341-641 |
description |
The intestinal mucosal barrier plays an important role in systemic immune functions. This study aimed to find the mechanism of peptide from Alaska Pollock (APP) on intestinal mucosal immunity in mice induced by cyclophosphamide (Cy). Cy-induced decreases of body weight and index of immune organ were significantly improved by APP as compared with Cy group ( p < 0.05). APP could promote the secretion of SIgA and IgA on intestinal mucosa ( p < 0.05) and mainly had an impact on the final differentiation of IgA + B cell, thereby promoting the secretion of plasma cells, which can be corroborated by the increases of IL-6 and IL-10 ( p < 0.05). APP with high immune activity was separated and two peptides were purified and identified as Gly−Val−Ile−Lys and Ala−Cys−Asn−Gly−Arg. Therefore, APP can be considered as beneficial ingredients to protect the intestinal barrier disruption induced by Cy. |
format |
Article in Journal/Newspaper |
author |
Qiqi Li Shikai Wang Supanooch Poungchawanwong Hu Hou |
author_facet |
Qiqi Li Shikai Wang Supanooch Poungchawanwong Hu Hou |
author_sort |
Qiqi Li |
title |
Effect of Peptides from Alaska Pollock on Intestinal Mucosal Immunity Function and Purification of Active Fragments |
title_short |
Effect of Peptides from Alaska Pollock on Intestinal Mucosal Immunity Function and Purification of Active Fragments |
title_full |
Effect of Peptides from Alaska Pollock on Intestinal Mucosal Immunity Function and Purification of Active Fragments |
title_fullStr |
Effect of Peptides from Alaska Pollock on Intestinal Mucosal Immunity Function and Purification of Active Fragments |
title_full_unstemmed |
Effect of Peptides from Alaska Pollock on Intestinal Mucosal Immunity Function and Purification of Active Fragments |
title_sort |
effect of peptides from alaska pollock on intestinal mucosal immunity function and purification of active fragments |
publisher |
MDPI AG |
publishDate |
2019 |
url |
https://doi.org/10.3390/nu11102517 https://doaj.org/article/b923eb549a184d55a588def0d0abe738 |
genre |
alaska pollock Alaska |
genre_facet |
alaska pollock Alaska |
op_source |
Nutrients, Vol 11, Iss 10, p 2517 (2019) |
op_relation |
https://www.mdpi.com/2072-6643/11/10/2517 https://doaj.org/toc/2072-6643 2072-6643 doi:10.3390/nu11102517 https://doaj.org/article/b923eb549a184d55a588def0d0abe738 |
op_doi |
https://doi.org/10.3390/nu11102517 |
container_title |
Nutrients |
container_volume |
11 |
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10 |
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2517 |
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1766171945166962688 |