Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework
Abstract Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia. Recently, knowlesi malaria has become the predominant malaria affecting humans in Malaysian...
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ftdoajarticles:oai:doaj.org/article:b92118c0c3e04ce4850549aad93b806e 2023-05-15T15:06:09+02:00 Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework Gael Davidson Tock H. Chua Angus Cook Peter Speldewinde Philip Weinstein 2019-03-01T00:00:00Z https://doi.org/10.1186/s12936-019-2693-2 https://doaj.org/article/b92118c0c3e04ce4850549aad93b806e EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2693-2 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2693-2 1475-2875 https://doaj.org/article/b92118c0c3e04ce4850549aad93b806e Malaria Journal, Vol 18, Iss 1, Pp 1-13 (2019) Malaria Zoonotic Plasmodium knowlesi Anthropogenic land use change Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2693-2 2022-12-31T03:34:06Z Abstract Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia. Recently, knowlesi malaria has become the predominant malaria affecting humans in Malaysian Borneo, being responsible for approximately 70% of reported cases. Largely as a result of anthropogenic land use changes in Borneo, vectors which transmit the parasite, along with macaque hosts, are both now frequently found in disturbed forest habitats, or at the forest fringes, thus having more frequent contact with humans. Having access to human hosts provides the parasite with the opportunity to further its adaption to the human immune system. The ecological drivers of the transmission and spread of P. knowlesi are operating over many different spatial (and, therefore, temporal) scales, from the molecular to the continental. Strategies to prevent and manage zoonoses, such as P. knowlesi malaria require interdisciplinary research exploring the impact of land use change and biodiversity loss on the evolving relationship between parasite, reservoir hosts, vectors, and humans over multiple spatial scales. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Zoonotic Plasmodium knowlesi Anthropogenic land use change Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Zoonotic Plasmodium knowlesi Anthropogenic land use change Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Gael Davidson Tock H. Chua Angus Cook Peter Speldewinde Philip Weinstein Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework |
topic_facet |
Malaria Zoonotic Plasmodium knowlesi Anthropogenic land use change Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia. Recently, knowlesi malaria has become the predominant malaria affecting humans in Malaysian Borneo, being responsible for approximately 70% of reported cases. Largely as a result of anthropogenic land use changes in Borneo, vectors which transmit the parasite, along with macaque hosts, are both now frequently found in disturbed forest habitats, or at the forest fringes, thus having more frequent contact with humans. Having access to human hosts provides the parasite with the opportunity to further its adaption to the human immune system. The ecological drivers of the transmission and spread of P. knowlesi are operating over many different spatial (and, therefore, temporal) scales, from the molecular to the continental. Strategies to prevent and manage zoonoses, such as P. knowlesi malaria require interdisciplinary research exploring the impact of land use change and biodiversity loss on the evolving relationship between parasite, reservoir hosts, vectors, and humans over multiple spatial scales. |
format |
Article in Journal/Newspaper |
author |
Gael Davidson Tock H. Chua Angus Cook Peter Speldewinde Philip Weinstein |
author_facet |
Gael Davidson Tock H. Chua Angus Cook Peter Speldewinde Philip Weinstein |
author_sort |
Gael Davidson |
title |
Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework |
title_short |
Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework |
title_full |
Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework |
title_fullStr |
Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework |
title_full_unstemmed |
Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework |
title_sort |
defining the ecological and evolutionary drivers of plasmodium knowlesi transmission within a multi-scale framework |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2693-2 https://doaj.org/article/b92118c0c3e04ce4850549aad93b806e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-13 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2693-2 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2693-2 1475-2875 https://doaj.org/article/b92118c0c3e04ce4850549aad93b806e |
op_doi |
https://doi.org/10.1186/s12936-019-2693-2 |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
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1766337806655815680 |