A case of Plasmodium malariae recurrence: recrudescence or reinfection?
Abstract Background Plasmodium malariae is the most neglected of the six human malaria species and it is still unknown which is the mechanism underlying the long latency of this Plasmodium. Case presentation A case of PCR-confirmed P. malariae recurrence in a 52-year old Italian man was observed 5 m...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2019
|
Subjects: | |
Online Access: | https://doi.org/10.1186/s12936-019-2806-y https://doaj.org/article/b91af425ac8640a08781b9aad69d099e |
id |
ftdoajarticles:oai:doaj.org/article:b91af425ac8640a08781b9aad69d099e |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:b91af425ac8640a08781b9aad69d099e 2023-05-15T15:06:27+02:00 A case of Plasmodium malariae recurrence: recrudescence or reinfection? Romualdo Grande Spinello Antinori Luca Meroni Michela Menegon Carlo Severini 2019-05-01T00:00:00Z https://doi.org/10.1186/s12936-019-2806-y https://doaj.org/article/b91af425ac8640a08781b9aad69d099e EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2806-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2806-y 1475-2875 https://doaj.org/article/b91af425ac8640a08781b9aad69d099e Malaria Journal, Vol 18, Iss 1, Pp 1-9 (2019) Plasmodium malariae Malaria Recrudescence Long-latency Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2806-y 2022-12-31T08:22:39Z Abstract Background Plasmodium malariae is the most neglected of the six human malaria species and it is still unknown which is the mechanism underlying the long latency of this Plasmodium. Case presentation A case of PCR-confirmed P. malariae recurrence in a 52-year old Italian man was observed 5 months after a primary attack. In the interval between the two observed episodes of malaria the patient denied any further stay in endemic areas except for a visit to Libya, a country considered malaria-free. Genomic DNA of the P. malariae strain using five microsatellites (PM2, PM9, PM11, PM25, PM34) and the antigen marker of circumsporozoite (csp) was amplified and sequenced. Analysis of polymorphisms of the P. malariae csp central repeat region showed differences between the strains responsible of the first and second episode of malaria. A difference in the allele size was also observed for the sequence analysis of PM2 microsatellites. Conclusions Plasmodium malariae is a challenging human malaria parasite and even with the use of molecular techniques the pathogenesis of recurrent episodes cannot be precisely explained. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Plasmodium malariae Malaria Recrudescence Long-latency Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Plasmodium malariae Malaria Recrudescence Long-latency Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Romualdo Grande Spinello Antinori Luca Meroni Michela Menegon Carlo Severini A case of Plasmodium malariae recurrence: recrudescence or reinfection? |
topic_facet |
Plasmodium malariae Malaria Recrudescence Long-latency Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Plasmodium malariae is the most neglected of the six human malaria species and it is still unknown which is the mechanism underlying the long latency of this Plasmodium. Case presentation A case of PCR-confirmed P. malariae recurrence in a 52-year old Italian man was observed 5 months after a primary attack. In the interval between the two observed episodes of malaria the patient denied any further stay in endemic areas except for a visit to Libya, a country considered malaria-free. Genomic DNA of the P. malariae strain using five microsatellites (PM2, PM9, PM11, PM25, PM34) and the antigen marker of circumsporozoite (csp) was amplified and sequenced. Analysis of polymorphisms of the P. malariae csp central repeat region showed differences between the strains responsible of the first and second episode of malaria. A difference in the allele size was also observed for the sequence analysis of PM2 microsatellites. Conclusions Plasmodium malariae is a challenging human malaria parasite and even with the use of molecular techniques the pathogenesis of recurrent episodes cannot be precisely explained. |
format |
Article in Journal/Newspaper |
author |
Romualdo Grande Spinello Antinori Luca Meroni Michela Menegon Carlo Severini |
author_facet |
Romualdo Grande Spinello Antinori Luca Meroni Michela Menegon Carlo Severini |
author_sort |
Romualdo Grande |
title |
A case of Plasmodium malariae recurrence: recrudescence or reinfection? |
title_short |
A case of Plasmodium malariae recurrence: recrudescence or reinfection? |
title_full |
A case of Plasmodium malariae recurrence: recrudescence or reinfection? |
title_fullStr |
A case of Plasmodium malariae recurrence: recrudescence or reinfection? |
title_full_unstemmed |
A case of Plasmodium malariae recurrence: recrudescence or reinfection? |
title_sort |
case of plasmodium malariae recurrence: recrudescence or reinfection? |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2806-y https://doaj.org/article/b91af425ac8640a08781b9aad69d099e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-9 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2806-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2806-y 1475-2875 https://doaj.org/article/b91af425ac8640a08781b9aad69d099e |
op_doi |
https://doi.org/10.1186/s12936-019-2806-y |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
_version_ |
1766338048161742848 |