Therapeutic efficacy of pyronaridine-artesunate (Pyramax®) against uncomplicated Plasmodium falciparum infection at Hamusit Health Centre, Northwest Ethiopia
Abstract Background Early case detection and prompt treatment are important malaria control and elimination strategies. However, the emergence and rapid spread of drug-resistant strains present a major challenge. This study reports the first therapeutic efficacy profile of pyronaridine-artesunate ag...
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ftdoajarticles:oai:doaj.org/article:b90835c0a0124cb7b9789e9b94fb2228 2023-07-16T03:57:06+02:00 Therapeutic efficacy of pyronaridine-artesunate (Pyramax®) against uncomplicated Plasmodium falciparum infection at Hamusit Health Centre, Northwest Ethiopia Mihreteab Alebachew Woyneshet Gelaye Megbaru Alemu Abate Heven Sime Henok Hailgiorgis Bokretsion Gidey Mebrahtom Haile Gudissa Assefa Worku Bekele Habtamu Belay Jonathan B. Parr Geremew Tasew Hussein Mohammed Ashenafi Assefa 2023-06-01T00:00:00Z https://doi.org/10.1186/s12936-023-04618-y https://doaj.org/article/b90835c0a0124cb7b9789e9b94fb2228 EN eng BMC https://doi.org/10.1186/s12936-023-04618-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04618-y 1475-2875 https://doaj.org/article/b90835c0a0124cb7b9789e9b94fb2228 Malaria Journal, Vol 22, Iss 1, Pp 1-10 (2023) Efficacy Ethiopia Hamusit P. falciparum Pyronaridine-artesunate Malaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1186/s12936-023-04618-y 2023-06-25T00:37:32Z Abstract Background Early case detection and prompt treatment are important malaria control and elimination strategies. However, the emergence and rapid spread of drug-resistant strains present a major challenge. This study reports the first therapeutic efficacy profile of pyronaridine-artesunate against uncomplicated Plasmodium falciparum in Northwest Ethiopia. Methods This single-arm prospective study with 42-day follow-up period was conducted from March to May 2021 at Hamusit Health Centre using the World Health Organization (WHO) therapeutic efficacy study protocol. A total of 90 adults ages 18 and older with uncomplicated falciparum malaria consented and were enrolled in the study. A standard single-dose regimen of pyronaridine-artesunate was administered daily for 3 days, and clinical and parasitological outcomes were assessed over 42 days of follow-up. Thick and thin blood films were prepared from capillary blood and examined using light microscopy. Haemoglobin was measured and dried blood spots were collected on day 0 and on the day of failure. Results Out of 90 patients, 86/90 (95.6%) completed the 42-day follow-up study period. The overall PCR-corrected cure rate (adequate clinical and parasitological response) was very high at 86/87 (98.9%) (95% CI: 92.2–99.8%) with no serious adverse events. The parasite clearance rate was high with fast resolution of clinical symptoms; 86/90 (95.6%) and 100% of the study participants cleared parasitaemia and fever on day 3, respectively. Conclusion Pyronaridine-artesunate was highly efficacious and safe against uncomplicated P. falciparum in this study population. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 22 1 |
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Efficacy Ethiopia Hamusit P. falciparum Pyronaridine-artesunate Malaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Efficacy Ethiopia Hamusit P. falciparum Pyronaridine-artesunate Malaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Mihreteab Alebachew Woyneshet Gelaye Megbaru Alemu Abate Heven Sime Henok Hailgiorgis Bokretsion Gidey Mebrahtom Haile Gudissa Assefa Worku Bekele Habtamu Belay Jonathan B. Parr Geremew Tasew Hussein Mohammed Ashenafi Assefa Therapeutic efficacy of pyronaridine-artesunate (Pyramax®) against uncomplicated Plasmodium falciparum infection at Hamusit Health Centre, Northwest Ethiopia |
topic_facet |
Efficacy Ethiopia Hamusit P. falciparum Pyronaridine-artesunate Malaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Early case detection and prompt treatment are important malaria control and elimination strategies. However, the emergence and rapid spread of drug-resistant strains present a major challenge. This study reports the first therapeutic efficacy profile of pyronaridine-artesunate against uncomplicated Plasmodium falciparum in Northwest Ethiopia. Methods This single-arm prospective study with 42-day follow-up period was conducted from March to May 2021 at Hamusit Health Centre using the World Health Organization (WHO) therapeutic efficacy study protocol. A total of 90 adults ages 18 and older with uncomplicated falciparum malaria consented and were enrolled in the study. A standard single-dose regimen of pyronaridine-artesunate was administered daily for 3 days, and clinical and parasitological outcomes were assessed over 42 days of follow-up. Thick and thin blood films were prepared from capillary blood and examined using light microscopy. Haemoglobin was measured and dried blood spots were collected on day 0 and on the day of failure. Results Out of 90 patients, 86/90 (95.6%) completed the 42-day follow-up study period. The overall PCR-corrected cure rate (adequate clinical and parasitological response) was very high at 86/87 (98.9%) (95% CI: 92.2–99.8%) with no serious adverse events. The parasite clearance rate was high with fast resolution of clinical symptoms; 86/90 (95.6%) and 100% of the study participants cleared parasitaemia and fever on day 3, respectively. Conclusion Pyronaridine-artesunate was highly efficacious and safe against uncomplicated P. falciparum in this study population. |
format |
Article in Journal/Newspaper |
author |
Mihreteab Alebachew Woyneshet Gelaye Megbaru Alemu Abate Heven Sime Henok Hailgiorgis Bokretsion Gidey Mebrahtom Haile Gudissa Assefa Worku Bekele Habtamu Belay Jonathan B. Parr Geremew Tasew Hussein Mohammed Ashenafi Assefa |
author_facet |
Mihreteab Alebachew Woyneshet Gelaye Megbaru Alemu Abate Heven Sime Henok Hailgiorgis Bokretsion Gidey Mebrahtom Haile Gudissa Assefa Worku Bekele Habtamu Belay Jonathan B. Parr Geremew Tasew Hussein Mohammed Ashenafi Assefa |
author_sort |
Mihreteab Alebachew |
title |
Therapeutic efficacy of pyronaridine-artesunate (Pyramax®) against uncomplicated Plasmodium falciparum infection at Hamusit Health Centre, Northwest Ethiopia |
title_short |
Therapeutic efficacy of pyronaridine-artesunate (Pyramax®) against uncomplicated Plasmodium falciparum infection at Hamusit Health Centre, Northwest Ethiopia |
title_full |
Therapeutic efficacy of pyronaridine-artesunate (Pyramax®) against uncomplicated Plasmodium falciparum infection at Hamusit Health Centre, Northwest Ethiopia |
title_fullStr |
Therapeutic efficacy of pyronaridine-artesunate (Pyramax®) against uncomplicated Plasmodium falciparum infection at Hamusit Health Centre, Northwest Ethiopia |
title_full_unstemmed |
Therapeutic efficacy of pyronaridine-artesunate (Pyramax®) against uncomplicated Plasmodium falciparum infection at Hamusit Health Centre, Northwest Ethiopia |
title_sort |
therapeutic efficacy of pyronaridine-artesunate (pyramax®) against uncomplicated plasmodium falciparum infection at hamusit health centre, northwest ethiopia |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s12936-023-04618-y https://doaj.org/article/b90835c0a0124cb7b9789e9b94fb2228 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 22, Iss 1, Pp 1-10 (2023) |
op_relation |
https://doi.org/10.1186/s12936-023-04618-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04618-y 1475-2875 https://doaj.org/article/b90835c0a0124cb7b9789e9b94fb2228 |
op_doi |
https://doi.org/10.1186/s12936-023-04618-y |
container_title |
Malaria Journal |
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22 |
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1 |
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1771543615999311872 |