Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe.
Coronary artery disease (CAD) mortality and morbidity is present in the European continent in a four-fold gradient across populations, from the South (Spain and France) with the lowest CAD mortality, towards the North (Finland and UK). This observed gradient has not been fully explained by classical...
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ftdoajarticles:oai:doaj.org/article:b901cd7149d6404396dd7da6540c01c3 2023-05-15T17:39:14+02:00 Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe. Robert Carreras-Torres Suman Kundu Daniela Zanetti Esther Esteban Marc Via Pedro Moral 2014-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0096504 https://doaj.org/article/b901cd7149d6404396dd7da6540c01c3 EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24806096/?tool=EBI https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0096504 https://doaj.org/article/b901cd7149d6404396dd7da6540c01c3 PLoS ONE, Vol 9, Iss 5, p e96504 (2014) Medicine R Science Q article 2014 ftdoajarticles https://doi.org/10.1371/journal.pone.0096504 2022-12-31T14:33:44Z Coronary artery disease (CAD) mortality and morbidity is present in the European continent in a four-fold gradient across populations, from the South (Spain and France) with the lowest CAD mortality, towards the North (Finland and UK). This observed gradient has not been fully explained by classical or single genetic risk factors, resulting in some cases in the so called Southern European or Mediterranean paradox. Here we approached population genetic risk estimates using genetic risk scores (GRS) constructed with single nucleotide polymorphisms (SNP) from nitric oxide synthases (NOS) genes. These SNPs appeared to be associated with myocardial infarction (MI) in 2165 cases and 2153 controls. The GRSs were computed in 34 general European populations. Although the contribution of these GRS was lower than 1% between cases and controls, the mean GRS per population was positively correlated with coronary incidence explaining 65-85% of the variation among populations (67% in women and 86% in men). This large contribution to CAD incidence variation among populations might be a result of colinearity with several other common genetic and environmental factors. These results are not consistent with the cardiovascular Mediterranean paradox for genetics and support a CAD genetic architecture mainly based on combinations of common genetic polymorphisms. Population genetic risk scores is a promising approach in public health interventions to develop lifestyle programs and prevent intermediate risk factors in certain subpopulations with specific genetic predisposition. Article in Journal/Newspaper North Finland Directory of Open Access Journals: DOAJ Articles PLoS ONE 9 5 e96504 |
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language |
English |
topic |
Medicine R Science Q |
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Medicine R Science Q Robert Carreras-Torres Suman Kundu Daniela Zanetti Esther Esteban Marc Via Pedro Moral Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe. |
topic_facet |
Medicine R Science Q |
description |
Coronary artery disease (CAD) mortality and morbidity is present in the European continent in a four-fold gradient across populations, from the South (Spain and France) with the lowest CAD mortality, towards the North (Finland and UK). This observed gradient has not been fully explained by classical or single genetic risk factors, resulting in some cases in the so called Southern European or Mediterranean paradox. Here we approached population genetic risk estimates using genetic risk scores (GRS) constructed with single nucleotide polymorphisms (SNP) from nitric oxide synthases (NOS) genes. These SNPs appeared to be associated with myocardial infarction (MI) in 2165 cases and 2153 controls. The GRSs were computed in 34 general European populations. Although the contribution of these GRS was lower than 1% between cases and controls, the mean GRS per population was positively correlated with coronary incidence explaining 65-85% of the variation among populations (67% in women and 86% in men). This large contribution to CAD incidence variation among populations might be a result of colinearity with several other common genetic and environmental factors. These results are not consistent with the cardiovascular Mediterranean paradox for genetics and support a CAD genetic architecture mainly based on combinations of common genetic polymorphisms. Population genetic risk scores is a promising approach in public health interventions to develop lifestyle programs and prevent intermediate risk factors in certain subpopulations with specific genetic predisposition. |
format |
Article in Journal/Newspaper |
author |
Robert Carreras-Torres Suman Kundu Daniela Zanetti Esther Esteban Marc Via Pedro Moral |
author_facet |
Robert Carreras-Torres Suman Kundu Daniela Zanetti Esther Esteban Marc Via Pedro Moral |
author_sort |
Robert Carreras-Torres |
title |
Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe. |
title_short |
Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe. |
title_full |
Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe. |
title_fullStr |
Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe. |
title_full_unstemmed |
Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe. |
title_sort |
genetic risk score of nos gene variants associated with myocardial infarction correlates with coronary incidence across europe. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pone.0096504 https://doaj.org/article/b901cd7149d6404396dd7da6540c01c3 |
genre |
North Finland |
genre_facet |
North Finland |
op_source |
PLoS ONE, Vol 9, Iss 5, p e96504 (2014) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24806096/?tool=EBI https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0096504 https://doaj.org/article/b901cd7149d6404396dd7da6540c01c3 |
op_doi |
https://doi.org/10.1371/journal.pone.0096504 |
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PLoS ONE |
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9 |
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5 |
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e96504 |
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