A cluster randomized trial of delivery of intermittent preventive treatment of malaria in pregnancy at the community level in Burkina Faso
Abstract Background Malaria in pregnancy is responsible for 8–14% of low birth weight and 20% of stillbirths in sub-Saharan Africa. To prevent these adverse consequences, the World Health Organization recommends intermittent preventive treatment of pregnant women (IPTp) with sulfadoxine–pyrimethamin...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2020
|
Subjects: | |
Online Access: | https://doi.org/10.1186/s12936-020-03356-9 https://doaj.org/article/b8fd9d49c0cf431e8daa5cf7e03c9183 |
id |
ftdoajarticles:oai:doaj.org/article:b8fd9d49c0cf431e8daa5cf7e03c9183 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:b8fd9d49c0cf431e8daa5cf7e03c9183 2023-05-15T15:18:03+02:00 A cluster randomized trial of delivery of intermittent preventive treatment of malaria in pregnancy at the community level in Burkina Faso Julie R. Gutman Daniel K. Stephens Justin Tiendrebeogo Ousmane Badolo Mathurin Dodo Danielle Burke John Williamson Kristen Vibbert Susan J. Youll Yacouba Savadogo William R. Brieger 2020-08-01T00:00:00Z https://doi.org/10.1186/s12936-020-03356-9 https://doaj.org/article/b8fd9d49c0cf431e8daa5cf7e03c9183 EN eng BMC http://link.springer.com/article/10.1186/s12936-020-03356-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03356-9 1475-2875 https://doaj.org/article/b8fd9d49c0cf431e8daa5cf7e03c9183 Malaria Journal, Vol 19, Iss 1, Pp 1-11 (2020) Malaria Pregnancy Intermittent preventive treatment Sulfadoxine–pyrimethamine Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-03356-9 2022-12-31T12:45:22Z Abstract Background Malaria in pregnancy is responsible for 8–14% of low birth weight and 20% of stillbirths in sub-Saharan Africa. To prevent these adverse consequences, the World Health Organization recommends intermittent preventive treatment of pregnant women (IPTp) with sulfadoxine–pyrimethamine be administered at each ANC visit starting as early as possible in the second trimester. Global IPTp coverage in targeted countries remains unacceptably low. Community delivery of IPTp was explored as a means to improve coverage. Methods A cluster randomized, controlled trial was conducted in 12 health facilities in a 1:1 ratio to either an intervention group (IPTp delivered by CHWs) or a control group (standard practice, with IPTp delivered at HFs) in three districts of Burkina Faso to assess the effect of IPTp administration by community health workers (CHWs) on the coverage of IPTp and antenatal care (ANC). The districts and facilities were purposively selected taking into account malaria epidemiology, IPTp coverage, and the presence of active CHWs. Pre- and post-intervention surveys were carried out in March 2017 and July–August 2018, respectively. A difference in differences (DiD) analysis was conducted to assess the change in coverage of IPTp and ANC over time, accounting for clustering at the health facility level. Results Altogether 374 and 360 women were included in the baseline and endline surveys, respectively. At baseline, women received a median of 2.1 doses; by endline, women received a median of 1.8 doses in the control group and 2.8 doses in the intervention group (p-value < 0.0001). There was a non-statistically significant increase in the proportion of women attending four ANC visits in the intervention compared to control group (DiD = 12.6%, p-value = 0.16). By the endline, administration of IPTp was higher in the intervention than control, with a DiD of 17.6% for IPTp3 (95% confidence interval (CI) − 16.3, 51.5; p-value 0.31) and 20.0% for IPTp4 (95% CI − 7.2, 47.3; p-value = 0.15). ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 19 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Pregnancy Intermittent preventive treatment Sulfadoxine–pyrimethamine Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Pregnancy Intermittent preventive treatment Sulfadoxine–pyrimethamine Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Julie R. Gutman Daniel K. Stephens Justin Tiendrebeogo Ousmane Badolo Mathurin Dodo Danielle Burke John Williamson Kristen Vibbert Susan J. Youll Yacouba Savadogo William R. Brieger A cluster randomized trial of delivery of intermittent preventive treatment of malaria in pregnancy at the community level in Burkina Faso |
topic_facet |
Malaria Pregnancy Intermittent preventive treatment Sulfadoxine–pyrimethamine Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria in pregnancy is responsible for 8–14% of low birth weight and 20% of stillbirths in sub-Saharan Africa. To prevent these adverse consequences, the World Health Organization recommends intermittent preventive treatment of pregnant women (IPTp) with sulfadoxine–pyrimethamine be administered at each ANC visit starting as early as possible in the second trimester. Global IPTp coverage in targeted countries remains unacceptably low. Community delivery of IPTp was explored as a means to improve coverage. Methods A cluster randomized, controlled trial was conducted in 12 health facilities in a 1:1 ratio to either an intervention group (IPTp delivered by CHWs) or a control group (standard practice, with IPTp delivered at HFs) in three districts of Burkina Faso to assess the effect of IPTp administration by community health workers (CHWs) on the coverage of IPTp and antenatal care (ANC). The districts and facilities were purposively selected taking into account malaria epidemiology, IPTp coverage, and the presence of active CHWs. Pre- and post-intervention surveys were carried out in March 2017 and July–August 2018, respectively. A difference in differences (DiD) analysis was conducted to assess the change in coverage of IPTp and ANC over time, accounting for clustering at the health facility level. Results Altogether 374 and 360 women were included in the baseline and endline surveys, respectively. At baseline, women received a median of 2.1 doses; by endline, women received a median of 1.8 doses in the control group and 2.8 doses in the intervention group (p-value < 0.0001). There was a non-statistically significant increase in the proportion of women attending four ANC visits in the intervention compared to control group (DiD = 12.6%, p-value = 0.16). By the endline, administration of IPTp was higher in the intervention than control, with a DiD of 17.6% for IPTp3 (95% confidence interval (CI) − 16.3, 51.5; p-value 0.31) and 20.0% for IPTp4 (95% CI − 7.2, 47.3; p-value = 0.15). ... |
format |
Article in Journal/Newspaper |
author |
Julie R. Gutman Daniel K. Stephens Justin Tiendrebeogo Ousmane Badolo Mathurin Dodo Danielle Burke John Williamson Kristen Vibbert Susan J. Youll Yacouba Savadogo William R. Brieger |
author_facet |
Julie R. Gutman Daniel K. Stephens Justin Tiendrebeogo Ousmane Badolo Mathurin Dodo Danielle Burke John Williamson Kristen Vibbert Susan J. Youll Yacouba Savadogo William R. Brieger |
author_sort |
Julie R. Gutman |
title |
A cluster randomized trial of delivery of intermittent preventive treatment of malaria in pregnancy at the community level in Burkina Faso |
title_short |
A cluster randomized trial of delivery of intermittent preventive treatment of malaria in pregnancy at the community level in Burkina Faso |
title_full |
A cluster randomized trial of delivery of intermittent preventive treatment of malaria in pregnancy at the community level in Burkina Faso |
title_fullStr |
A cluster randomized trial of delivery of intermittent preventive treatment of malaria in pregnancy at the community level in Burkina Faso |
title_full_unstemmed |
A cluster randomized trial of delivery of intermittent preventive treatment of malaria in pregnancy at the community level in Burkina Faso |
title_sort |
cluster randomized trial of delivery of intermittent preventive treatment of malaria in pregnancy at the community level in burkina faso |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-03356-9 https://doaj.org/article/b8fd9d49c0cf431e8daa5cf7e03c9183 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 19, Iss 1, Pp 1-11 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s12936-020-03356-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03356-9 1475-2875 https://doaj.org/article/b8fd9d49c0cf431e8daa5cf7e03c9183 |
op_doi |
https://doi.org/10.1186/s12936-020-03356-9 |
container_title |
Malaria Journal |
container_volume |
19 |
container_issue |
1 |
_version_ |
1766348283734654976 |