Adherence to Dihydroartemisinin + Piperaquine Treatment Regimen in Low and High Endemic Areas in Indonesia
After decades of successful artemisinin regimen in combating malaria, its effectiveness has decreased since parasite resistance to the treatment regimen has begun to appear. Adherence to artemisinin combination therapy (ACT) in a population is considered to be the key factor contributing to such res...
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ftdoajarticles:oai:doaj.org/article:b8e77921d76e427382a003b9e13be332 2024-09-09T19:27:18+00:00 Adherence to Dihydroartemisinin + Piperaquine Treatment Regimen in Low and High Endemic Areas in Indonesia Irfanul Chakim Tepanata Pumpaibool null Sayono Ekha Rifki Fauzi 2022-01-01T00:00:00Z https://doi.org/10.1155/2022/4317522 https://doaj.org/article/b8e77921d76e427382a003b9e13be332 EN eng Wiley http://dx.doi.org/10.1155/2022/4317522 https://doaj.org/toc/1687-9694 1687-9694 doi:10.1155/2022/4317522 https://doaj.org/article/b8e77921d76e427382a003b9e13be332 Journal of Tropical Medicine, Vol 2022 (2022) Arctic medicine. Tropical medicine RC955-962 article 2022 ftdoajarticles https://doi.org/10.1155/2022/4317522 2024-08-05T17:48:32Z After decades of successful artemisinin regimen in combating malaria, its effectiveness has decreased since parasite resistance to the treatment regimen has begun to appear. Adherence to artemisinin combination therapy (ACT) in a population is considered to be the key factor contributing to such resistance phenomenon. Although several studies have tried to demonstrate adherence to several ACT types in a population, only a limited number of studies demonstrated adherence to dihyrdroartemisinin + piperaquine (DHP) regimen. The present study was conducted in two localities representing low and high endemic areas in Indonesia. Active case detection (ACD) and passive case detection (PCD) have been applied to screen for malaria case in the localities. At day 3, patients were visited in the house to be interviewed using structured questionnaire. Capillary sample of each patient was also collected on Whatman® filter paper at day 60 to observe the piperaquine metabolite of the patients. 47 and 91 (out of 62 and 138) patients from Jambi and Sumba, respectively, were successfully enrolled in this study. In Jambi, the level of adherence was 66%, while that in Sumba was 79.1%. The associated factors of adherence in our study settings are patient age group (OR = 1.65 [CI: 0.73–3.73]) and patients’ knowledge of malaria prevention measure (OR = 0.29 [CI: 0.09–0.9]). Our study suggested that the adherence to ACT medication among population in our study setting is considered to be less than 80%, which needs to be elevated to avoid the growing trend of treatment failure as seen globally. Additionally, our study found that metabolite at day 60 after prescription of piperaquine could be a potential marker for monitoring adherence to piperaquine drug in a population. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Sumba ENVELOPE(-6.712,-6.712,61.403,61.403) Journal of Tropical Medicine 2022 1 11 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
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Arctic medicine. Tropical medicine RC955-962 Irfanul Chakim Tepanata Pumpaibool null Sayono Ekha Rifki Fauzi Adherence to Dihydroartemisinin + Piperaquine Treatment Regimen in Low and High Endemic Areas in Indonesia |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
After decades of successful artemisinin regimen in combating malaria, its effectiveness has decreased since parasite resistance to the treatment regimen has begun to appear. Adherence to artemisinin combination therapy (ACT) in a population is considered to be the key factor contributing to such resistance phenomenon. Although several studies have tried to demonstrate adherence to several ACT types in a population, only a limited number of studies demonstrated adherence to dihyrdroartemisinin + piperaquine (DHP) regimen. The present study was conducted in two localities representing low and high endemic areas in Indonesia. Active case detection (ACD) and passive case detection (PCD) have been applied to screen for malaria case in the localities. At day 3, patients were visited in the house to be interviewed using structured questionnaire. Capillary sample of each patient was also collected on Whatman® filter paper at day 60 to observe the piperaquine metabolite of the patients. 47 and 91 (out of 62 and 138) patients from Jambi and Sumba, respectively, were successfully enrolled in this study. In Jambi, the level of adherence was 66%, while that in Sumba was 79.1%. The associated factors of adherence in our study settings are patient age group (OR = 1.65 [CI: 0.73–3.73]) and patients’ knowledge of malaria prevention measure (OR = 0.29 [CI: 0.09–0.9]). Our study suggested that the adherence to ACT medication among population in our study setting is considered to be less than 80%, which needs to be elevated to avoid the growing trend of treatment failure as seen globally. Additionally, our study found that metabolite at day 60 after prescription of piperaquine could be a potential marker for monitoring adherence to piperaquine drug in a population. |
format |
Article in Journal/Newspaper |
author |
Irfanul Chakim Tepanata Pumpaibool null Sayono Ekha Rifki Fauzi |
author_facet |
Irfanul Chakim Tepanata Pumpaibool null Sayono Ekha Rifki Fauzi |
author_sort |
Irfanul Chakim |
title |
Adherence to Dihydroartemisinin + Piperaquine Treatment Regimen in Low and High Endemic Areas in Indonesia |
title_short |
Adherence to Dihydroartemisinin + Piperaquine Treatment Regimen in Low and High Endemic Areas in Indonesia |
title_full |
Adherence to Dihydroartemisinin + Piperaquine Treatment Regimen in Low and High Endemic Areas in Indonesia |
title_fullStr |
Adherence to Dihydroartemisinin + Piperaquine Treatment Regimen in Low and High Endemic Areas in Indonesia |
title_full_unstemmed |
Adherence to Dihydroartemisinin + Piperaquine Treatment Regimen in Low and High Endemic Areas in Indonesia |
title_sort |
adherence to dihydroartemisinin + piperaquine treatment regimen in low and high endemic areas in indonesia |
publisher |
Wiley |
publishDate |
2022 |
url |
https://doi.org/10.1155/2022/4317522 https://doaj.org/article/b8e77921d76e427382a003b9e13be332 |
long_lat |
ENVELOPE(-6.712,-6.712,61.403,61.403) |
geographic |
Arctic Sumba |
geographic_facet |
Arctic Sumba |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2022 (2022) |
op_relation |
http://dx.doi.org/10.1155/2022/4317522 https://doaj.org/toc/1687-9694 1687-9694 doi:10.1155/2022/4317522 https://doaj.org/article/b8e77921d76e427382a003b9e13be332 |
op_doi |
https://doi.org/10.1155/2022/4317522 |
container_title |
Journal of Tropical Medicine |
container_volume |
2022 |
container_start_page |
1 |
op_container_end_page |
11 |
_version_ |
1809896759654088704 |