Escalating Plasmodium falciparum antifolate drug resistance mutations in Macha, rural Zambia

• Published in: Malaria Journal
• Main Authors: Rouse Petrica, Sikalima Jay, Chishimba Sandra, Mkulama Mtawa AP, Thuma Philip E, Mharakurwa Sungano
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2008
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; Macha
• Online Access: https://doi.org/10.1186/1475-2875-7-87; https://doaj.org/article/b8dbff646e33409da428d530df1cdc93

Abstract Background In Zambia the first-line treatment for uncomplicated malaria is artemisinin combination therapy (ACT), with artemether-lumefantrine currently being used. However, the antifolate regimen, sulphadoxine-pyrimethamine (SP), remains the treatment of choice in children weighing less th...