Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study.
Background Despite visceral leishmaniasis (VL) being epidemic in most Brazilian regions, the Northeast region is responsible for the highest morbidity and mortality outcomes within the country. Objective To analyse the spatiotemporal dynamics of VL cases to identify the temporal trends and high-risk...
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ftdoajarticles:oai:doaj.org/article:b8db68dd90854e08a406f9997d5d0848 2023-05-15T15:11:39+02:00 Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study. Caique J N Ribeiro Allan D Dos Santos Shirley V M A Lima Eliete R da Silva Bianca V S Ribeiro Andrezza M Duque Marcus V S Peixoto Priscila L Dos Santos Iris M de Oliveira Michael W Lipscomb Karina C G M de Araújo Tatiana R de Moura 2021-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009006 https://doaj.org/article/b8db68dd90854e08a406f9997d5d0848 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009006 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009006 https://doaj.org/article/b8db68dd90854e08a406f9997d5d0848 PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0009006 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009006 2022-12-31T13:14:37Z Background Despite visceral leishmaniasis (VL) being epidemic in most Brazilian regions, the Northeast region is responsible for the highest morbidity and mortality outcomes within the country. Objective To analyse the spatiotemporal dynamics of VL cases to identify the temporal trends and high-risk areas for VL transmission, as well as the association of the disease with social vulnerability in Brazilian Northeast. Methods We carried out an ecological time series study employing spatial analysis techniques using all VL confirmed cases of 1,794 municipalities of Brazilian Northeast between the years 2000 to 2017. The Social Vulnerability Index (SVI) was used to represent the social vulnerability. Incidence rates were standardized and smoothed by the Local Empirical Bayesian Method. Time trends were examined through segmented linear regression. Spatiotemporal analysis consisted of uni- and bivariate Global and Local Moran indexes and space-time scan statistics. Results Incidence rate remained stable and ranged from 4.84 to 3.52 cases/100,000 inhabitants. There was higher case prevalence between males (62.71%), children and adolescents (63.27%), non-white (69.75%) and urban residents (62.58%). Increasing trends of new cases were observed among adult male subjects (≥ 40 years old) and urban residents. Importantly, VL incidence showed a direct spatial dependence. Spatial and space-time clusters were identified in sertão and meio-norte sub-regions, overlapping with high social vulnerability areas. Conclusions VL is a persistent health issue in Brazilian Northeast and associated with social vulnerability. Space-time clustering of VL cases in socially vulnerable municipalities demands intersectoral public policies of surveillance and control, with focus on reducing inequalities and improving living conditions for regional inhabitants. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 1 e0009006 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Caique J N Ribeiro Allan D Dos Santos Shirley V M A Lima Eliete R da Silva Bianca V S Ribeiro Andrezza M Duque Marcus V S Peixoto Priscila L Dos Santos Iris M de Oliveira Michael W Lipscomb Karina C G M de Araújo Tatiana R de Moura Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Despite visceral leishmaniasis (VL) being epidemic in most Brazilian regions, the Northeast region is responsible for the highest morbidity and mortality outcomes within the country. Objective To analyse the spatiotemporal dynamics of VL cases to identify the temporal trends and high-risk areas for VL transmission, as well as the association of the disease with social vulnerability in Brazilian Northeast. Methods We carried out an ecological time series study employing spatial analysis techniques using all VL confirmed cases of 1,794 municipalities of Brazilian Northeast between the years 2000 to 2017. The Social Vulnerability Index (SVI) was used to represent the social vulnerability. Incidence rates were standardized and smoothed by the Local Empirical Bayesian Method. Time trends were examined through segmented linear regression. Spatiotemporal analysis consisted of uni- and bivariate Global and Local Moran indexes and space-time scan statistics. Results Incidence rate remained stable and ranged from 4.84 to 3.52 cases/100,000 inhabitants. There was higher case prevalence between males (62.71%), children and adolescents (63.27%), non-white (69.75%) and urban residents (62.58%). Increasing trends of new cases were observed among adult male subjects (≥ 40 years old) and urban residents. Importantly, VL incidence showed a direct spatial dependence. Spatial and space-time clusters were identified in sertão and meio-norte sub-regions, overlapping with high social vulnerability areas. Conclusions VL is a persistent health issue in Brazilian Northeast and associated with social vulnerability. Space-time clustering of VL cases in socially vulnerable municipalities demands intersectoral public policies of surveillance and control, with focus on reducing inequalities and improving living conditions for regional inhabitants. |
format |
Article in Journal/Newspaper |
author |
Caique J N Ribeiro Allan D Dos Santos Shirley V M A Lima Eliete R da Silva Bianca V S Ribeiro Andrezza M Duque Marcus V S Peixoto Priscila L Dos Santos Iris M de Oliveira Michael W Lipscomb Karina C G M de Araújo Tatiana R de Moura |
author_facet |
Caique J N Ribeiro Allan D Dos Santos Shirley V M A Lima Eliete R da Silva Bianca V S Ribeiro Andrezza M Duque Marcus V S Peixoto Priscila L Dos Santos Iris M de Oliveira Michael W Lipscomb Karina C G M de Araújo Tatiana R de Moura |
author_sort |
Caique J N Ribeiro |
title |
Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study. |
title_short |
Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study. |
title_full |
Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study. |
title_fullStr |
Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study. |
title_full_unstemmed |
Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study. |
title_sort |
space-time risk cluster of visceral leishmaniasis in brazilian endemic region with high social vulnerability: an ecological time series study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009006 https://doaj.org/article/b8db68dd90854e08a406f9997d5d0848 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0009006 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009006 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009006 https://doaj.org/article/b8db68dd90854e08a406f9997d5d0848 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009006 |
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PLOS Neglected Tropical Diseases |
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15 |
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1 |
container_start_page |
e0009006 |
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