Gene polymorphism of mannose-binding lectin-associated serine protease (MASP2) in indigenous populations of the Russian Arctic Territories

• Published in: Russian Journal of Infection and Immunity
• Main Authors: Marina V. Smolnikova, M. A. Malinchik, S. Y. Tereschenko
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: Sankt-Peterburg : NIIÈM imeni Pastera 2022
• Subjects: masp2; polymorphism; newborns; russia; arctic populations; lectin pathway; Infectious and parasitic diseases; RC109-216; Arctic; Taymyr; Dolgan-Nenets; nenets; Nganasan*; Siberia
• Online Access: https://doi.org/10.15789/2220-7619-GPO-1712; https://doaj.org/article/b888ece5d02942ddbad7704ebc44d38b

Mannose-binding lectin-associated serine proteases (MASP) are among of the key components in the lectin pathway (LP) of the complement activation. MASP-2 is the most studied agent among specific enzymes activating both mannose-binding lectin (MBL) and ficolins, pattern-recognition proteins involved...