Schistosoma mansoni circulating polysaccharide and protein antigens recognized by sheep antisera in patients with different clinical forms of schistosomiasis before and after treatment Antígenos polissacarídicos e proteicos circulantes de Schistosoma mansoni reconhecidos por antissoros de carneiro em pacientes com diferentes formas clínicas da esquistossomose antes e após o tratamento
Two sheep antisera, one of which raised against polysaccharide (Po) and other against protein (Pt) components of Schistosoma mansoni adult worms, were assessed by ELISA for their ability to detect circulating parasite antigens in patients with different clinical forms of chronic schistosomiasis mans...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
1994
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ftdoajarticles:oai:doaj.org/article:b855f5aa98fd4a6e9eb824d52f8aecdb 2024-09-09T19:28:27+00:00 Schistosoma mansoni circulating polysaccharide and protein antigens recognized by sheep antisera in patients with different clinical forms of schistosomiasis before and after treatment Antígenos polissacarídicos e proteicos circulantes de Schistosoma mansoni reconhecidos por antissoros de carneiro em pacientes com diferentes formas clínicas da esquistossomose antes e após o tratamento Julia Maria Costa-Cruz Sumie Hoshino-Shimizu Antonio Walter Ferreira Mario E. Camargo Thales de Brito Luiz Caetano da Silva 1994-08-01T00:00:00Z https://doi.org/10.1590/S0036-46651994000400004 https://doaj.org/article/b855f5aa98fd4a6e9eb824d52f8aecdb EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651994000400004 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651994000400004 0036-4665 1678-9946 https://doaj.org/article/b855f5aa98fd4a6e9eb824d52f8aecdb Revista do Instituto de Medicina Tropical de São Paulo, Vol 36, Iss 4, Pp 321-325 (1994) Chronic schistosomiasis Circulating antigens Chemotherapy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1994 ftdoajarticles https://doi.org/10.1590/S0036-46651994000400004 2024-08-05T17:49:31Z Two sheep antisera, one of which raised against polysaccharide (Po) and other against protein (Pt) components of Schistosoma mansoni adult worms, were assessed by ELISA for their ability to detect circulating parasite antigens in patients with different clinical forms of chronic schistosomiasis mansoni. The former antiserum detected parasite antigens in liver granulomata and the latter in renal glomeruli from schistosomiasis patients and mice experimentally infected with S. mansoni. In general, the levels and/or positivity rate of circulating antigens and specific IgG antibodies were significantly higher in patients with hepatointestinal (HI) and hepatosplenic (HS) forms than in mild intestinal (I) forms. An association between Po antigens and clinical features of the disease was observed, as the level of these antigens was low (137 ng/ml) as well as the positivity rate (7.9%) in patients with I forms; values that were intermediate (593 ng/ml and 33.3%) in those with HI forms, and high (1.563 ng/ml and 50.0%) in more severe HS forms. The Pt antigens were detected in the studied clinical forms not differing statistically but, the positivity rate was significantly higher in HS forms comparatively to I forms. The antisera studied revealed distinct circulating antigen profiles, and the prognostic value of Po and Pt antigens was suggested. Dois antissoros produzidos em carneiros, um dos quais contra a fração polissacarídica (Po) e outro contra componentes protéicos (Pt) de vermes adultos de Schistosoma mansoni, foram avaliados quanto ao seu desempenho na detecção de antígenos parasitários circulantes em pacientes com diferentes formas clínicas da esquistossomose mansônica cr��nica, através de um ensaio imunoenzimático, (ELISA). O primeiro antissoro revelava antígenos parasitários no granuloma hepático e o segundo, nos glomérulos renais de pacientes com esquistossomose mansônica, bem como em camundongos experimentalmente infectados pelo S. mansoni. Em geral, os níveis bem como a positividade, de antígenos circulantes ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 36 4 321 325 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Chronic schistosomiasis Circulating antigens Chemotherapy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Chronic schistosomiasis Circulating antigens Chemotherapy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Julia Maria Costa-Cruz Sumie Hoshino-Shimizu Antonio Walter Ferreira Mario E. Camargo Thales de Brito Luiz Caetano da Silva Schistosoma mansoni circulating polysaccharide and protein antigens recognized by sheep antisera in patients with different clinical forms of schistosomiasis before and after treatment Antígenos polissacarídicos e proteicos circulantes de Schistosoma mansoni reconhecidos por antissoros de carneiro em pacientes com diferentes formas clínicas da esquistossomose antes e após o tratamento |
topic_facet |
Chronic schistosomiasis Circulating antigens Chemotherapy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Two sheep antisera, one of which raised against polysaccharide (Po) and other against protein (Pt) components of Schistosoma mansoni adult worms, were assessed by ELISA for their ability to detect circulating parasite antigens in patients with different clinical forms of chronic schistosomiasis mansoni. The former antiserum detected parasite antigens in liver granulomata and the latter in renal glomeruli from schistosomiasis patients and mice experimentally infected with S. mansoni. In general, the levels and/or positivity rate of circulating antigens and specific IgG antibodies were significantly higher in patients with hepatointestinal (HI) and hepatosplenic (HS) forms than in mild intestinal (I) forms. An association between Po antigens and clinical features of the disease was observed, as the level of these antigens was low (137 ng/ml) as well as the positivity rate (7.9%) in patients with I forms; values that were intermediate (593 ng/ml and 33.3%) in those with HI forms, and high (1.563 ng/ml and 50.0%) in more severe HS forms. The Pt antigens were detected in the studied clinical forms not differing statistically but, the positivity rate was significantly higher in HS forms comparatively to I forms. The antisera studied revealed distinct circulating antigen profiles, and the prognostic value of Po and Pt antigens was suggested. Dois antissoros produzidos em carneiros, um dos quais contra a fração polissacarídica (Po) e outro contra componentes protéicos (Pt) de vermes adultos de Schistosoma mansoni, foram avaliados quanto ao seu desempenho na detecção de antígenos parasitários circulantes em pacientes com diferentes formas clínicas da esquistossomose mansônica cr��nica, através de um ensaio imunoenzimático, (ELISA). O primeiro antissoro revelava antígenos parasitários no granuloma hepático e o segundo, nos glomérulos renais de pacientes com esquistossomose mansônica, bem como em camundongos experimentalmente infectados pelo S. mansoni. Em geral, os níveis bem como a positividade, de antígenos circulantes ... |
format |
Article in Journal/Newspaper |
author |
Julia Maria Costa-Cruz Sumie Hoshino-Shimizu Antonio Walter Ferreira Mario E. Camargo Thales de Brito Luiz Caetano da Silva |
author_facet |
Julia Maria Costa-Cruz Sumie Hoshino-Shimizu Antonio Walter Ferreira Mario E. Camargo Thales de Brito Luiz Caetano da Silva |
author_sort |
Julia Maria Costa-Cruz |
title |
Schistosoma mansoni circulating polysaccharide and protein antigens recognized by sheep antisera in patients with different clinical forms of schistosomiasis before and after treatment Antígenos polissacarídicos e proteicos circulantes de Schistosoma mansoni reconhecidos por antissoros de carneiro em pacientes com diferentes formas clínicas da esquistossomose antes e após o tratamento |
title_short |
Schistosoma mansoni circulating polysaccharide and protein antigens recognized by sheep antisera in patients with different clinical forms of schistosomiasis before and after treatment Antígenos polissacarídicos e proteicos circulantes de Schistosoma mansoni reconhecidos por antissoros de carneiro em pacientes com diferentes formas clínicas da esquistossomose antes e após o tratamento |
title_full |
Schistosoma mansoni circulating polysaccharide and protein antigens recognized by sheep antisera in patients with different clinical forms of schistosomiasis before and after treatment Antígenos polissacarídicos e proteicos circulantes de Schistosoma mansoni reconhecidos por antissoros de carneiro em pacientes com diferentes formas clínicas da esquistossomose antes e após o tratamento |
title_fullStr |
Schistosoma mansoni circulating polysaccharide and protein antigens recognized by sheep antisera in patients with different clinical forms of schistosomiasis before and after treatment Antígenos polissacarídicos e proteicos circulantes de Schistosoma mansoni reconhecidos por antissoros de carneiro em pacientes com diferentes formas clínicas da esquistossomose antes e após o tratamento |
title_full_unstemmed |
Schistosoma mansoni circulating polysaccharide and protein antigens recognized by sheep antisera in patients with different clinical forms of schistosomiasis before and after treatment Antígenos polissacarídicos e proteicos circulantes de Schistosoma mansoni reconhecidos por antissoros de carneiro em pacientes com diferentes formas clínicas da esquistossomose antes e após o tratamento |
title_sort |
schistosoma mansoni circulating polysaccharide and protein antigens recognized by sheep antisera in patients with different clinical forms of schistosomiasis before and after treatment antígenos polissacarídicos e proteicos circulantes de schistosoma mansoni reconhecidos por antissoros de carneiro em pacientes com diferentes formas clínicas da esquistossomose antes e após o tratamento |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1994 |
url |
https://doi.org/10.1590/S0036-46651994000400004 https://doaj.org/article/b855f5aa98fd4a6e9eb824d52f8aecdb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 36, Iss 4, Pp 321-325 (1994) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651994000400004 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651994000400004 0036-4665 1678-9946 https://doaj.org/article/b855f5aa98fd4a6e9eb824d52f8aecdb |
op_doi |
https://doi.org/10.1590/S0036-46651994000400004 |
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