Survival analysis of 198 patients with pancreatic cancer in Hainan, China: A multi-institution prospective study
Objective: To explore the survival status and prognostic factors of patients with pancreatic cancer in Hainan. Methods: Clinical data of patients who were diagnosed as pancreatic cancer and visited the First and Second Affiliated Hospital of Hainan Medical University and Haikou People’s Hospital fro...
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ftdoajarticles:oai:doaj.org/article:b789f07bedcd4cc899e16ba7d803fd8c 2023-05-15T15:12:49+02:00 Survival analysis of 198 patients with pancreatic cancer in Hainan, China: A multi-institution prospective study Zao-Xi Sun Yong-Mei Shen Zheng-Ke Sun Kai Li C M Emmanuel Yan Yang Yong-Jiang Zhou Hai-Rong Huang 2019-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.271977 https://doaj.org/article/b789f07bedcd4cc899e16ba7d803fd8c EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=14;spage=25;epage=31;aulast=Sun https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.271977 https://doaj.org/article/b789f07bedcd4cc899e16ba7d803fd8c Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 14, Pp 25-31 (2019) pancreatic cancer survival analysis risk factor tropical area Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.4103/1995-7645.271977 2022-12-31T08:55:25Z Objective: To explore the survival status and prognostic factors of patients with pancreatic cancer in Hainan. Methods: Clinical data of patients who were diagnosed as pancreatic cancer and visited the First and Second Affiliated Hospital of Hainan Medical University and Haikou People’s Hospital from 2013 to 2017 were collected based on electronic medical records. Basic information was collected by a self-designed questionnaire. Data about admission examinations including blood routine examination, blood biochemistry tests, tumour markers tests, imaging examination and other clinical tests were also collected. The date of follow-up via telephone was 30 June 2018. The survival rate was analyzed by the Kaplan–Meier method and the logrank test. Univariate and multivariate analyses were performed with COX regression model. Results: A total of 198 patients were included in the study. Kaplan–Meier results showed that the overall survival (OS) in 6 months and 1, 2, 3 and 5 years was 47.4%, 26.8%, 16.4%, 13.2%, and 8.7%, respectively. The median OS was 5.8 months. Log-rank test analysis found that there were significant differences in OS among patients with different age, surgery status, distant metastasis or absolute number of neutrophils, percentage of neutrophils, absolute number of lymphocytes, neutrophil-to-lymphocyte ratio (NLR), CA199 and carcino-embryonic antigen (P<0.1). COX multivariate analysis showed that age, surgical presence, presence or absence of distant metastasis and NLR were significantly associated OS (P<0.05). Conclusions: Older age, higher NLR and liver or lung metastasis are independent risk factors, while surgical treatment is an independent protective factor for patients with pancreatic cancer. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Meier ENVELOPE(-45.900,-45.900,-60.633,-60.633) Asian Pacific Journal of Tropical Medicine 12 14 25 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
pancreatic cancer survival analysis risk factor tropical area Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
pancreatic cancer survival analysis risk factor tropical area Arctic medicine. Tropical medicine RC955-962 Zao-Xi Sun Yong-Mei Shen Zheng-Ke Sun Kai Li C M Emmanuel Yan Yang Yong-Jiang Zhou Hai-Rong Huang Survival analysis of 198 patients with pancreatic cancer in Hainan, China: A multi-institution prospective study |
topic_facet |
pancreatic cancer survival analysis risk factor tropical area Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To explore the survival status and prognostic factors of patients with pancreatic cancer in Hainan. Methods: Clinical data of patients who were diagnosed as pancreatic cancer and visited the First and Second Affiliated Hospital of Hainan Medical University and Haikou People’s Hospital from 2013 to 2017 were collected based on electronic medical records. Basic information was collected by a self-designed questionnaire. Data about admission examinations including blood routine examination, blood biochemistry tests, tumour markers tests, imaging examination and other clinical tests were also collected. The date of follow-up via telephone was 30 June 2018. The survival rate was analyzed by the Kaplan–Meier method and the logrank test. Univariate and multivariate analyses were performed with COX regression model. Results: A total of 198 patients were included in the study. Kaplan–Meier results showed that the overall survival (OS) in 6 months and 1, 2, 3 and 5 years was 47.4%, 26.8%, 16.4%, 13.2%, and 8.7%, respectively. The median OS was 5.8 months. Log-rank test analysis found that there were significant differences in OS among patients with different age, surgery status, distant metastasis or absolute number of neutrophils, percentage of neutrophils, absolute number of lymphocytes, neutrophil-to-lymphocyte ratio (NLR), CA199 and carcino-embryonic antigen (P<0.1). COX multivariate analysis showed that age, surgical presence, presence or absence of distant metastasis and NLR were significantly associated OS (P<0.05). Conclusions: Older age, higher NLR and liver or lung metastasis are independent risk factors, while surgical treatment is an independent protective factor for patients with pancreatic cancer. |
format |
Article in Journal/Newspaper |
author |
Zao-Xi Sun Yong-Mei Shen Zheng-Ke Sun Kai Li C M Emmanuel Yan Yang Yong-Jiang Zhou Hai-Rong Huang |
author_facet |
Zao-Xi Sun Yong-Mei Shen Zheng-Ke Sun Kai Li C M Emmanuel Yan Yang Yong-Jiang Zhou Hai-Rong Huang |
author_sort |
Zao-Xi Sun |
title |
Survival analysis of 198 patients with pancreatic cancer in Hainan, China: A multi-institution prospective study |
title_short |
Survival analysis of 198 patients with pancreatic cancer in Hainan, China: A multi-institution prospective study |
title_full |
Survival analysis of 198 patients with pancreatic cancer in Hainan, China: A multi-institution prospective study |
title_fullStr |
Survival analysis of 198 patients with pancreatic cancer in Hainan, China: A multi-institution prospective study |
title_full_unstemmed |
Survival analysis of 198 patients with pancreatic cancer in Hainan, China: A multi-institution prospective study |
title_sort |
survival analysis of 198 patients with pancreatic cancer in hainan, china: a multi-institution prospective study |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2019 |
url |
https://doi.org/10.4103/1995-7645.271977 https://doaj.org/article/b789f07bedcd4cc899e16ba7d803fd8c |
long_lat |
ENVELOPE(-45.900,-45.900,-60.633,-60.633) |
geographic |
Arctic Meier |
geographic_facet |
Arctic Meier |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 12, Iss 14, Pp 25-31 (2019) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=14;spage=25;epage=31;aulast=Sun https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.271977 https://doaj.org/article/b789f07bedcd4cc899e16ba7d803fd8c |
op_doi |
https://doi.org/10.4103/1995-7645.271977 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
12 |
container_issue |
14 |
container_start_page |
25 |
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1766343447377084416 |