Protective and therapeutic potentials of Dunaliella salina on aging-associated cardiac dysfunction in rats
Objective: To investigate the possible protective and/or therapeutic potentials of Dunaliella salina (D. salina) biomass, its carotenoid and polar fractions on cardiac dysfunction associated with D-galactose (D-GAL) induced aging in rats. Methods: Aging associated cardiac dysfunction was induced in...
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ftdoajarticles:oai:doaj.org/article:b76a0dadd0ff43a8b25c8b664530a68d 2023-05-15T15:12:16+02:00 Protective and therapeutic potentials of Dunaliella salina on aging-associated cardiac dysfunction in rats Farouk K El-Baz Gehad A Abdel Jaleel Dalia O Saleh Rehab A Hussein 2018-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.239428 https://doaj.org/article/b76a0dadd0ff43a8b25c8b664530a68d EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=8;spage=403;epage=410;aulast=El-Baz https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.239428 https://doaj.org/article/b76a0dadd0ff43a8b25c8b664530a68d Asian Pacific Journal of Tropical Biomedicine, Vol 8, Iss 8, Pp 403-410 (2018) aging cardiac dysfunction dunaliella salina rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2018 ftdoajarticles https://doi.org/10.4103/2221-1691.239428 2022-12-31T13:11:10Z Objective: To investigate the possible protective and/or therapeutic potentials of Dunaliella salina (D. salina) biomass, its carotenoid and polar fractions on cardiac dysfunction associated with D-galactose (D-GAL) induced aging in rats. Methods: Aging associated cardiac dysfunction was induced in rats by injection of D-GAL (200 mg/kg; i.p) for 8 weeks. D-GAL injected rats were treated with two regimens; protective regimen where D. salina biomass (250 mg/kg), its carotenoid (250 μg/kg) and polar (250 μg/kg) fractions were given orally for two weeks concurrently with D-GAL injection as well as treatment regimen where the three treatments were given orally for 28 consecutive days after D-GAL injection. Results: D-GAL injection for 8 weeks was accompanied with dramatic electrocardiographic changes as well as profound elevation in serum levels of homocysteine, creatinine kinase isoenzyme and lactate dehydrogenase in addition to the reduction of the cardiac content of glucose trasporter 4. D-GAL also induced reduction in cardiac superoxide dismutase activity and elevation of inducible nitric oxide synthetase and interleukin-6. On the other hand, oral administration of D. salina carotenoid fraction as well as the total biomass significantly attenuated the D-GAL-induced disturbances in the above mentioned parameters where the protective regimen appeared more successful in controlling the manifestations of cardiac dysfunction. The histopathological examination further emphasized the promising results. Besides, the HPLC analysis of the carotenoid fraction of D. salina revealed the presence of 2.31% β -carotene. Conclusions: D. salina carotenoid fraction as well as the total biomass ameliorate D-GAL-induced aging associated cardiac dysfunction which is attributed to the potent antioxidant activity of β -carotene. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 8 8 403 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
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language |
English |
topic |
aging cardiac dysfunction dunaliella salina rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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aging cardiac dysfunction dunaliella salina rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Farouk K El-Baz Gehad A Abdel Jaleel Dalia O Saleh Rehab A Hussein Protective and therapeutic potentials of Dunaliella salina on aging-associated cardiac dysfunction in rats |
topic_facet |
aging cardiac dysfunction dunaliella salina rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate the possible protective and/or therapeutic potentials of Dunaliella salina (D. salina) biomass, its carotenoid and polar fractions on cardiac dysfunction associated with D-galactose (D-GAL) induced aging in rats. Methods: Aging associated cardiac dysfunction was induced in rats by injection of D-GAL (200 mg/kg; i.p) for 8 weeks. D-GAL injected rats were treated with two regimens; protective regimen where D. salina biomass (250 mg/kg), its carotenoid (250 μg/kg) and polar (250 μg/kg) fractions were given orally for two weeks concurrently with D-GAL injection as well as treatment regimen where the three treatments were given orally for 28 consecutive days after D-GAL injection. Results: D-GAL injection for 8 weeks was accompanied with dramatic electrocardiographic changes as well as profound elevation in serum levels of homocysteine, creatinine kinase isoenzyme and lactate dehydrogenase in addition to the reduction of the cardiac content of glucose trasporter 4. D-GAL also induced reduction in cardiac superoxide dismutase activity and elevation of inducible nitric oxide synthetase and interleukin-6. On the other hand, oral administration of D. salina carotenoid fraction as well as the total biomass significantly attenuated the D-GAL-induced disturbances in the above mentioned parameters where the protective regimen appeared more successful in controlling the manifestations of cardiac dysfunction. The histopathological examination further emphasized the promising results. Besides, the HPLC analysis of the carotenoid fraction of D. salina revealed the presence of 2.31% β -carotene. Conclusions: D. salina carotenoid fraction as well as the total biomass ameliorate D-GAL-induced aging associated cardiac dysfunction which is attributed to the potent antioxidant activity of β -carotene. |
format |
Article in Journal/Newspaper |
author |
Farouk K El-Baz Gehad A Abdel Jaleel Dalia O Saleh Rehab A Hussein |
author_facet |
Farouk K El-Baz Gehad A Abdel Jaleel Dalia O Saleh Rehab A Hussein |
author_sort |
Farouk K El-Baz |
title |
Protective and therapeutic potentials of Dunaliella salina on aging-associated cardiac dysfunction in rats |
title_short |
Protective and therapeutic potentials of Dunaliella salina on aging-associated cardiac dysfunction in rats |
title_full |
Protective and therapeutic potentials of Dunaliella salina on aging-associated cardiac dysfunction in rats |
title_fullStr |
Protective and therapeutic potentials of Dunaliella salina on aging-associated cardiac dysfunction in rats |
title_full_unstemmed |
Protective and therapeutic potentials of Dunaliella salina on aging-associated cardiac dysfunction in rats |
title_sort |
protective and therapeutic potentials of dunaliella salina on aging-associated cardiac dysfunction in rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/2221-1691.239428 https://doaj.org/article/b76a0dadd0ff43a8b25c8b664530a68d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 8, Iss 8, Pp 403-410 (2018) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=8;spage=403;epage=410;aulast=El-Baz https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.239428 https://doaj.org/article/b76a0dadd0ff43a8b25c8b664530a68d |
op_doi |
https://doi.org/10.4103/2221-1691.239428 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
8 |
container_issue |
8 |
container_start_page |
403 |
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1766342980218650624 |