Staphylococcus aureus with inducible clindamycin resistance and methicillin resistance in a tertiary hospital in Nepal
Abstract Background Staphylococcus aureus is a global public health issue in both community and hospital settings. Management of methicillin-resistant S. aureus (MRSA) infections are tough owing to its resistance to many antibiotics. Macrolide-lincosamide-streptogramin B (MLSB) antibiotics are commo...
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ftdoajarticles:oai:doaj.org/article:b74bfd186d0740229e60d560ef368874 2023-05-15T15:07:52+02:00 Staphylococcus aureus with inducible clindamycin resistance and methicillin resistance in a tertiary hospital in Nepal Devi Thapa Susil Pyakurel Sabita Thapa Suresh Lamsal Mahesh Chaudhari Nabaraj Adhikari Dhiraj Shrestha 2021-12-01T00:00:00Z https://doi.org/10.1186/s41182-021-00392-2 https://doaj.org/article/b74bfd186d0740229e60d560ef368874 EN eng BMC https://doi.org/10.1186/s41182-021-00392-2 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-021-00392-2 1349-4147 https://doaj.org/article/b74bfd186d0740229e60d560ef368874 Tropical Medicine and Health, Vol 49, Iss 1, Pp 1-7 (2021) Inducible clindamycin resistance MRSA Nepal S. aureus Arctic medicine. Tropical medicine RC955-962 article 2021 ftdoajarticles https://doi.org/10.1186/s41182-021-00392-2 2022-12-31T16:22:53Z Abstract Background Staphylococcus aureus is a global public health issue in both community and hospital settings. Management of methicillin-resistant S. aureus (MRSA) infections are tough owing to its resistance to many antibiotics. Macrolide-lincosamide-streptogramin B (MLSB) antibiotics are commonly used for the management of MRSA. This study was aimed to determine the occurrence of inducible clindamycin- and methicillin-resistant S. aureus at a tertiary care hospital in Kathmandu, Nepal. Methods A total of 1027 clinical samples were processed following standard laboratory procedures and antibiotic susceptibility testing of S. aureus was performed by disc diffusion method. MRSA isolates were detected phenotypically using cefoxitin disc, and inducible clindamycin resistance was detected phenotypically using the D-zone test. Results Of 1027 samples, 321 (31.2%) were culture positive, of which 38 (11.8%) were S. aureus. All S. aureus isolates were susceptible to vancomycin, and 25 (67%) of S. aureus isolates were multidrug-resistant. Similarly, 15 (39.5%) of S. aureus were MRSA and 14 (36.5%) were inducible clindamycin-resistant phenotypes. Conclusion Inducible clindamycin and methicillin resistance were common in S. aureus. This emphasizes that the methicillin resistance test and the D-zone test should be incorporated into the routine antibiotic susceptibility testing in hospital settings. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Tropical Medicine and Health 49 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Inducible clindamycin resistance MRSA Nepal S. aureus Arctic medicine. Tropical medicine RC955-962 |
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Inducible clindamycin resistance MRSA Nepal S. aureus Arctic medicine. Tropical medicine RC955-962 Devi Thapa Susil Pyakurel Sabita Thapa Suresh Lamsal Mahesh Chaudhari Nabaraj Adhikari Dhiraj Shrestha Staphylococcus aureus with inducible clindamycin resistance and methicillin resistance in a tertiary hospital in Nepal |
topic_facet |
Inducible clindamycin resistance MRSA Nepal S. aureus Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background Staphylococcus aureus is a global public health issue in both community and hospital settings. Management of methicillin-resistant S. aureus (MRSA) infections are tough owing to its resistance to many antibiotics. Macrolide-lincosamide-streptogramin B (MLSB) antibiotics are commonly used for the management of MRSA. This study was aimed to determine the occurrence of inducible clindamycin- and methicillin-resistant S. aureus at a tertiary care hospital in Kathmandu, Nepal. Methods A total of 1027 clinical samples were processed following standard laboratory procedures and antibiotic susceptibility testing of S. aureus was performed by disc diffusion method. MRSA isolates were detected phenotypically using cefoxitin disc, and inducible clindamycin resistance was detected phenotypically using the D-zone test. Results Of 1027 samples, 321 (31.2%) were culture positive, of which 38 (11.8%) were S. aureus. All S. aureus isolates were susceptible to vancomycin, and 25 (67%) of S. aureus isolates were multidrug-resistant. Similarly, 15 (39.5%) of S. aureus were MRSA and 14 (36.5%) were inducible clindamycin-resistant phenotypes. Conclusion Inducible clindamycin and methicillin resistance were common in S. aureus. This emphasizes that the methicillin resistance test and the D-zone test should be incorporated into the routine antibiotic susceptibility testing in hospital settings. |
format |
Article in Journal/Newspaper |
author |
Devi Thapa Susil Pyakurel Sabita Thapa Suresh Lamsal Mahesh Chaudhari Nabaraj Adhikari Dhiraj Shrestha |
author_facet |
Devi Thapa Susil Pyakurel Sabita Thapa Suresh Lamsal Mahesh Chaudhari Nabaraj Adhikari Dhiraj Shrestha |
author_sort |
Devi Thapa |
title |
Staphylococcus aureus with inducible clindamycin resistance and methicillin resistance in a tertiary hospital in Nepal |
title_short |
Staphylococcus aureus with inducible clindamycin resistance and methicillin resistance in a tertiary hospital in Nepal |
title_full |
Staphylococcus aureus with inducible clindamycin resistance and methicillin resistance in a tertiary hospital in Nepal |
title_fullStr |
Staphylococcus aureus with inducible clindamycin resistance and methicillin resistance in a tertiary hospital in Nepal |
title_full_unstemmed |
Staphylococcus aureus with inducible clindamycin resistance and methicillin resistance in a tertiary hospital in Nepal |
title_sort |
staphylococcus aureus with inducible clindamycin resistance and methicillin resistance in a tertiary hospital in nepal |
publisher |
BMC |
publishDate |
2021 |
url |
https://doi.org/10.1186/s41182-021-00392-2 https://doaj.org/article/b74bfd186d0740229e60d560ef368874 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Medicine and Health, Vol 49, Iss 1, Pp 1-7 (2021) |
op_relation |
https://doi.org/10.1186/s41182-021-00392-2 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-021-00392-2 1349-4147 https://doaj.org/article/b74bfd186d0740229e60d560ef368874 |
op_doi |
https://doi.org/10.1186/s41182-021-00392-2 |
container_title |
Tropical Medicine and Health |
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49 |
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1 |
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1766339275678285824 |