Toxoplasmosis among pregnant women: High seroprevalence and risk factors in Kinshasa, Democratic Republic of Congo

Objective: To determine the seroprevalence of toxoplasmosis in pregnant women, as well as the proportion of acutely infected and risk factors in the Democratic Republic of Congo. Methods: Thirty maternities in Kinshasa were randomly selected and women attending antenatal consultation were invited to...

Full description

Bibliographic Details
Published in:Asian Pacific Journal of Tropical Biomedicine
Main Authors: Yobi Doudou, Piarroux Renaud, L'Ollivier Coralie, Franck Jacqueline, Situakibanza Hypolite, Muhindo Hypolite, Mitashi Patrick, Inocêncio da Luz Raquel Andreia, Marc Van Sprundel, Boelaert Marleen, Jean-Pierre Van Geertruyden, Lutumba Pascal
Format: Article in Journal/Newspaper
Language:English
Published: Wolters Kluwer Medknow Publications 2014
Subjects:
Seroprevalence
Toxoplasmosis
Pregnant women
Kinshasa
Arctic medicine. Tropical medicine
RC955-962
Biology (General)
QH301-705.5
Arctic
Online Access:https://doi.org/10.1016/S2221-1691(14)60211-2
https://doaj.org/article/b720ef19f74e499c9ee969d197c1fb23
Description
Summary:Objective: To determine the seroprevalence of toxoplasmosis in pregnant women, as well as the proportion of acutely infected and risk factors in the Democratic Republic of Congo. Methods: Thirty maternities in Kinshasa were randomly selected and women attending antenatal consultation were invited to participate. They were interviewed with a structured questionnaire about known risk factors (age, meat consumption, contact with soil, and presence of cat) and a venous blood sample was taken. Sera were analysed for total immunoglobulins (Ig) by VIDAS Toxo Competition using Enzyme Linked Fluorescent Assay. IgM was determined by VIDIA Toxo IgM and IgG avidity by VIDAS Toxo IgG avidity. Results: A total of 781 women were included. Median age was 28 years old (IQR: 8.5). And 627 women (80.3%; 95% CI: 77.5–83.1) were found to be positive to total Ig and 17 out of 387 (4.4%; 95% CI: 2.3–6.4) were positive to IgM. IgG avidity was low for 2 (11.8%) women, intermediate for 2 (11.8%) and high for 13 women (76.4%). There was no statistically significant association between Toxoplasma gondii infection and any risk factors assessed. Conclusion: In Kinshasa, toxoplasmosis endemicity is highly prevalent. One woman out of twenty five had a recent toxoplasmosis infection and 20% were not protected against primo-infection, indicating a need for measures to prevent and control toxoplasmosis during pregnancy.

Similar Items