Phylogeography and population structure of Glossina fuscipes fuscipes in Uganda: implications for control of tsetse.
Glossina fuscipes fuscipes, a riverine species of tsetse, is the main vector of both human and animal trypanosomiasis in Uganda. Successful implementation of vector control will require establishing an appropriate geographical scale for these activities. Population genetics can help to resolve this...
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ftdoajarticles:oai:doaj.org/article:b7182645733c42bb94c9c5b1b62955ff 2023-05-15T15:16:28+02:00 Phylogeography and population structure of Glossina fuscipes fuscipes in Uganda: implications for control of tsetse. Jon S Beadell Chaz Hyseni Patrick P Abila Rogers Azabo John C K Enyaru Johnson O Ouma Yassir O Mohammed Loyce M Okedi Serap Aksoy Adalgisa Caccone 2010-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000636 https://doaj.org/article/b7182645733c42bb94c9c5b1b62955ff EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2838784?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000636 https://doaj.org/article/b7182645733c42bb94c9c5b1b62955ff PLoS Neglected Tropical Diseases, Vol 4, Iss 3, p e636 (2010) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000636 2022-12-31T02:44:12Z Glossina fuscipes fuscipes, a riverine species of tsetse, is the main vector of both human and animal trypanosomiasis in Uganda. Successful implementation of vector control will require establishing an appropriate geographical scale for these activities. Population genetics can help to resolve this issue by characterizing the extent of linkage among apparently isolated groups of tsetse.We conducted genetic analyses on mitochondrial and microsatellite data accumulated from approximately 1000 individual tsetse captured in Uganda and neighboring regions of Kenya and Sudan. Phylogeographic analyses suggested that the largest scale genetic structure in G. f. fuscipes arose from an historical event that divided two divergent mitochondrial lineages. These lineages are currently partitioned to northern and southern Uganda and co-occur only in a narrow zone of contact extending across central Uganda. Bayesian assignment tests, which provided evidence for admixture between northern and southern flies at the zone of contact and evidence for northerly gene flow across the zone of contact, indicated that this structure may be impermanent. On the other hand, microsatellite structure within the southern lineage indicated that gene flow is currently limited between populations in western and southeastern Uganda. Within regions, the average F(ST) between populations separated by less than 100 km was less than approximately 0.1. Significant tests of isolation by distance suggested that gene flow is ongoing between neighboring populations and that island populations are not uniformly more isolated than mainland populations.Despite the presence of population structure arising from historical colonization events, our results have revealed strong signals of current gene flow within regions that should be accounted for when planning tsetse control in Uganda. Populations in southeastern Uganda appeared to receive little gene flow from populations in western or northern Uganda, supporting the feasibility of area wide control in the Lake ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 4 3 e636 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jon S Beadell Chaz Hyseni Patrick P Abila Rogers Azabo John C K Enyaru Johnson O Ouma Yassir O Mohammed Loyce M Okedi Serap Aksoy Adalgisa Caccone Phylogeography and population structure of Glossina fuscipes fuscipes in Uganda: implications for control of tsetse. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Glossina fuscipes fuscipes, a riverine species of tsetse, is the main vector of both human and animal trypanosomiasis in Uganda. Successful implementation of vector control will require establishing an appropriate geographical scale for these activities. Population genetics can help to resolve this issue by characterizing the extent of linkage among apparently isolated groups of tsetse.We conducted genetic analyses on mitochondrial and microsatellite data accumulated from approximately 1000 individual tsetse captured in Uganda and neighboring regions of Kenya and Sudan. Phylogeographic analyses suggested that the largest scale genetic structure in G. f. fuscipes arose from an historical event that divided two divergent mitochondrial lineages. These lineages are currently partitioned to northern and southern Uganda and co-occur only in a narrow zone of contact extending across central Uganda. Bayesian assignment tests, which provided evidence for admixture between northern and southern flies at the zone of contact and evidence for northerly gene flow across the zone of contact, indicated that this structure may be impermanent. On the other hand, microsatellite structure within the southern lineage indicated that gene flow is currently limited between populations in western and southeastern Uganda. Within regions, the average F(ST) between populations separated by less than 100 km was less than approximately 0.1. Significant tests of isolation by distance suggested that gene flow is ongoing between neighboring populations and that island populations are not uniformly more isolated than mainland populations.Despite the presence of population structure arising from historical colonization events, our results have revealed strong signals of current gene flow within regions that should be accounted for when planning tsetse control in Uganda. Populations in southeastern Uganda appeared to receive little gene flow from populations in western or northern Uganda, supporting the feasibility of area wide control in the Lake ... |
format |
Article in Journal/Newspaper |
author |
Jon S Beadell Chaz Hyseni Patrick P Abila Rogers Azabo John C K Enyaru Johnson O Ouma Yassir O Mohammed Loyce M Okedi Serap Aksoy Adalgisa Caccone |
author_facet |
Jon S Beadell Chaz Hyseni Patrick P Abila Rogers Azabo John C K Enyaru Johnson O Ouma Yassir O Mohammed Loyce M Okedi Serap Aksoy Adalgisa Caccone |
author_sort |
Jon S Beadell |
title |
Phylogeography and population structure of Glossina fuscipes fuscipes in Uganda: implications for control of tsetse. |
title_short |
Phylogeography and population structure of Glossina fuscipes fuscipes in Uganda: implications for control of tsetse. |
title_full |
Phylogeography and population structure of Glossina fuscipes fuscipes in Uganda: implications for control of tsetse. |
title_fullStr |
Phylogeography and population structure of Glossina fuscipes fuscipes in Uganda: implications for control of tsetse. |
title_full_unstemmed |
Phylogeography and population structure of Glossina fuscipes fuscipes in Uganda: implications for control of tsetse. |
title_sort |
phylogeography and population structure of glossina fuscipes fuscipes in uganda: implications for control of tsetse. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pntd.0000636 https://doaj.org/article/b7182645733c42bb94c9c5b1b62955ff |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 4, Iss 3, p e636 (2010) |
op_relation |
http://europepmc.org/articles/PMC2838784?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000636 https://doaj.org/article/b7182645733c42bb94c9c5b1b62955ff |
op_doi |
https://doi.org/10.1371/journal.pntd.0000636 |
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PLoS Neglected Tropical Diseases |
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4 |
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3 |
container_start_page |
e636 |
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