The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland
Abstract Cardiovascular disease (CVD) is a well-known complication of diabetes, but the association has not been studied among Inuit in Greenland. The aim was to examine the association between diabetes and incident CVD among Inuit in Greenland and determine if the common diabetogenic TBC1D4 variant...
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ftdoajarticles:oai:doaj.org/article:b7078b340f8c4ce48c137ac95eaee21d 2023-05-15T16:25:15+02:00 The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland Maria Overvad Lars Jorge Diaz Peter Bjerregaard Michael Lynge Pedersen Christina Viskum Lytken Larsen Ninna Senftleber Niels Grarup Torben Hansen Marit Eika Jørgensen 2020-12-01T00:00:00Z https://doi.org/10.1038/s41598-020-79132-1 https://doaj.org/article/b7078b340f8c4ce48c137ac95eaee21d EN eng Nature Portfolio https://doi.org/10.1038/s41598-020-79132-1 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-020-79132-1 2045-2322 https://doaj.org/article/b7078b340f8c4ce48c137ac95eaee21d Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Medicine R Science Q article 2020 ftdoajarticles https://doi.org/10.1038/s41598-020-79132-1 2022-12-31T09:18:55Z Abstract Cardiovascular disease (CVD) is a well-known complication of diabetes, but the association has not been studied among Inuit in Greenland. The aim was to examine the association between diabetes and incident CVD among Inuit in Greenland and determine if the common diabetogenic TBC1D4 variant confers increased risk of CVD. We followed an initial study population of 4127 adults in Greenland who had participated in at least one population-based health survey, in national registers. We used Poisson regression to calculate incidence rate ratios (IRR) of cardiovascular endpoints, comparing participants with and without diabetes and comparing homozygous TBC1D4 carriers with heterozygous carriers and non-carriers combined. Close to 10% had diabetes and age range was 18–96 years (45% male). Of the 3924 participants without prior CVD, 362 (~ 9%) had CVD events during a median follow-up of 10 years. Multivariate IRR for the effect of diabetes on CVD was 1.12 (95% CI: 0.80, 1.57) p = 0.50. Using a recessive genetic model, we compared homozygous TBC1D4 carriers with wildtype and heterozygous carriers combined, with a multivariate IRR of 1.20 (95% CI: 0.69, 2.11) p = 0.52. Neither diabetes nor the TBC1D4 variant significantly increased CVD risk among Inuit in Greenland in adjusted models. Article in Journal/Newspaper Greenland inuit Directory of Open Access Journals: DOAJ Articles Greenland Scientific Reports 10 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Medicine R Science Q |
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Medicine R Science Q Maria Overvad Lars Jorge Diaz Peter Bjerregaard Michael Lynge Pedersen Christina Viskum Lytken Larsen Ninna Senftleber Niels Grarup Torben Hansen Marit Eika Jørgensen The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
topic_facet |
Medicine R Science Q |
description |
Abstract Cardiovascular disease (CVD) is a well-known complication of diabetes, but the association has not been studied among Inuit in Greenland. The aim was to examine the association between diabetes and incident CVD among Inuit in Greenland and determine if the common diabetogenic TBC1D4 variant confers increased risk of CVD. We followed an initial study population of 4127 adults in Greenland who had participated in at least one population-based health survey, in national registers. We used Poisson regression to calculate incidence rate ratios (IRR) of cardiovascular endpoints, comparing participants with and without diabetes and comparing homozygous TBC1D4 carriers with heterozygous carriers and non-carriers combined. Close to 10% had diabetes and age range was 18–96 years (45% male). Of the 3924 participants without prior CVD, 362 (~ 9%) had CVD events during a median follow-up of 10 years. Multivariate IRR for the effect of diabetes on CVD was 1.12 (95% CI: 0.80, 1.57) p = 0.50. Using a recessive genetic model, we compared homozygous TBC1D4 carriers with wildtype and heterozygous carriers combined, with a multivariate IRR of 1.20 (95% CI: 0.69, 2.11) p = 0.52. Neither diabetes nor the TBC1D4 variant significantly increased CVD risk among Inuit in Greenland in adjusted models. |
format |
Article in Journal/Newspaper |
author |
Maria Overvad Lars Jorge Diaz Peter Bjerregaard Michael Lynge Pedersen Christina Viskum Lytken Larsen Ninna Senftleber Niels Grarup Torben Hansen Marit Eika Jørgensen |
author_facet |
Maria Overvad Lars Jorge Diaz Peter Bjerregaard Michael Lynge Pedersen Christina Viskum Lytken Larsen Ninna Senftleber Niels Grarup Torben Hansen Marit Eika Jørgensen |
author_sort |
Maria Overvad |
title |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_short |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_full |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_fullStr |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_full_unstemmed |
The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland |
title_sort |
effect of diabetes and the common diabetogenic tbc1d4 p.arg684ter variant on cardiovascular risk in inuit in greenland |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doi.org/10.1038/s41598-020-79132-1 https://doaj.org/article/b7078b340f8c4ce48c137ac95eaee21d |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit |
genre_facet |
Greenland inuit |
op_source |
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) |
op_relation |
https://doi.org/10.1038/s41598-020-79132-1 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-020-79132-1 2045-2322 https://doaj.org/article/b7078b340f8c4ce48c137ac95eaee21d |
op_doi |
https://doi.org/10.1038/s41598-020-79132-1 |
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Scientific Reports |
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10 |
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1 |
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1766013987299786752 |