High dietary magnesium intake is associated with low insulin resistance in the Newfoundland population.
Magnesium plays a role in glucose and insulin homeostasis and evidence suggests that magnesium intake is associated with insulin resistance (IR). However, data is inconsistent and most studies have not adequately controlled for critical confounding factors.The study investigated the association betw...
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ftdoajarticles:oai:doaj.org/article:b701ba626964423dbab3eed7d75e56b5 2023-05-15T17:22:47+02:00 High dietary magnesium intake is associated with low insulin resistance in the Newfoundland population. Farrell Cahill Mariam Shahidi Jennifer Shea Danny Wadden Wayne Gulliver Edward Randell Sudesh Vasdev Guang Sun 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0058278 https://doaj.org/article/b701ba626964423dbab3eed7d75e56b5 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3589265?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0058278 https://doaj.org/article/b701ba626964423dbab3eed7d75e56b5 PLoS ONE, Vol 8, Iss 3, p e58278 (2013) Medicine R Science Q article 2013 ftdoajarticles https://doi.org/10.1371/journal.pone.0058278 2022-12-31T08:17:16Z Magnesium plays a role in glucose and insulin homeostasis and evidence suggests that magnesium intake is associated with insulin resistance (IR). However, data is inconsistent and most studies have not adequately controlled for critical confounding factors.The study investigated the association between magnesium intake and IR in normal-weight (NW), overweight (OW) and obese (OB) along with pre- and post- menopausal women.A total of 2295 subjects (590 men and 1705 women) were recruited from the CODING study. Dietary magnesium intake was computed from the Willett Food Frequency Questionnaire (FFQ). Adiposity (NW, OW and OB) was classified by body fat percentage () measured by Dual-energy X-ray absorptiometry according to the Bray criteria. Multiple regression analyses were used to test adiposity-specific associations of dietary magnesium intake on insulin resistance adjusting for caloric intake, physical activity, medication use and menopausal status.Subjects with the highest intakes of dietary magnesium had the lowest levels of circulating insulin, HOMA-IR, and HOMA-ß and subjects with the lowest intake of dietary magnesium had the highest levels of these measures, suggesting a dose effect. Multiple regression analysis revealed a strong inverse association between dietary magnesium with IR. In addition, adiposity and menopausal status were found to be critical factors revealing that the association between dietary magnesium and IR was stronger in OW and OB along with Pre-menopausal women.The results of this study indicate that higher dietary magnesium intake is strongly associated with the attenuation of insulin resistance and is more beneficial for overweight and obese individuals in the general population and pre-menopausal women. Moreover, the inverse correlation between insulin resistance and dietary magnesium intake is stronger when adjusting for than BMI. Article in Journal/Newspaper Newfoundland Directory of Open Access Journals: DOAJ Articles Bray ENVELOPE(-114.067,-114.067,-74.833,-74.833) PLoS ONE 8 3 e58278 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Farrell Cahill Mariam Shahidi Jennifer Shea Danny Wadden Wayne Gulliver Edward Randell Sudesh Vasdev Guang Sun High dietary magnesium intake is associated with low insulin resistance in the Newfoundland population. |
topic_facet |
Medicine R Science Q |
description |
Magnesium plays a role in glucose and insulin homeostasis and evidence suggests that magnesium intake is associated with insulin resistance (IR). However, data is inconsistent and most studies have not adequately controlled for critical confounding factors.The study investigated the association between magnesium intake and IR in normal-weight (NW), overweight (OW) and obese (OB) along with pre- and post- menopausal women.A total of 2295 subjects (590 men and 1705 women) were recruited from the CODING study. Dietary magnesium intake was computed from the Willett Food Frequency Questionnaire (FFQ). Adiposity (NW, OW and OB) was classified by body fat percentage () measured by Dual-energy X-ray absorptiometry according to the Bray criteria. Multiple regression analyses were used to test adiposity-specific associations of dietary magnesium intake on insulin resistance adjusting for caloric intake, physical activity, medication use and menopausal status.Subjects with the highest intakes of dietary magnesium had the lowest levels of circulating insulin, HOMA-IR, and HOMA-ß and subjects with the lowest intake of dietary magnesium had the highest levels of these measures, suggesting a dose effect. Multiple regression analysis revealed a strong inverse association between dietary magnesium with IR. In addition, adiposity and menopausal status were found to be critical factors revealing that the association between dietary magnesium and IR was stronger in OW and OB along with Pre-menopausal women.The results of this study indicate that higher dietary magnesium intake is strongly associated with the attenuation of insulin resistance and is more beneficial for overweight and obese individuals in the general population and pre-menopausal women. Moreover, the inverse correlation between insulin resistance and dietary magnesium intake is stronger when adjusting for than BMI. |
format |
Article in Journal/Newspaper |
author |
Farrell Cahill Mariam Shahidi Jennifer Shea Danny Wadden Wayne Gulliver Edward Randell Sudesh Vasdev Guang Sun |
author_facet |
Farrell Cahill Mariam Shahidi Jennifer Shea Danny Wadden Wayne Gulliver Edward Randell Sudesh Vasdev Guang Sun |
author_sort |
Farrell Cahill |
title |
High dietary magnesium intake is associated with low insulin resistance in the Newfoundland population. |
title_short |
High dietary magnesium intake is associated with low insulin resistance in the Newfoundland population. |
title_full |
High dietary magnesium intake is associated with low insulin resistance in the Newfoundland population. |
title_fullStr |
High dietary magnesium intake is associated with low insulin resistance in the Newfoundland population. |
title_full_unstemmed |
High dietary magnesium intake is associated with low insulin resistance in the Newfoundland population. |
title_sort |
high dietary magnesium intake is associated with low insulin resistance in the newfoundland population. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pone.0058278 https://doaj.org/article/b701ba626964423dbab3eed7d75e56b5 |
long_lat |
ENVELOPE(-114.067,-114.067,-74.833,-74.833) |
geographic |
Bray |
geographic_facet |
Bray |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
PLoS ONE, Vol 8, Iss 3, p e58278 (2013) |
op_relation |
http://europepmc.org/articles/PMC3589265?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0058278 https://doaj.org/article/b701ba626964423dbab3eed7d75e56b5 |
op_doi |
https://doi.org/10.1371/journal.pone.0058278 |
container_title |
PLoS ONE |
container_volume |
8 |
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3 |
container_start_page |
e58278 |
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