A biodistribution study of Hemiscorpius lepturus scorpion venom and available polyclonal antivenom in rats
The purpose of the present study was to investigate the biodistribution profile of the venom of Hemiscorpius lepturus, the most dangerous scorpion in Iran. Blood and tissue samples were taken at various predetermined intervals during a 400-minute period for the venom and a 360-minute period for the...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:b6cd48693c9248a3a94609839a822b3d 2023-05-15T15:07:48+02:00 A biodistribution study of Hemiscorpius lepturus scorpion venom and available polyclonal antivenom in rats R Seyedian A Jalali MH Babaee MH Pipelzadeh S Rezaee 2012-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992012000400005 https://doaj.org/article/b6cd48693c9248a3a94609839a822b3d EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000400005 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992012000400005 1678-9199 https://doaj.org/article/b6cd48693c9248a3a94609839a822b3d Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 18, Iss 4, Pp 375-383 (2012) Hemiscorpius lepturus scorpion venom polyvalent antivenom pharmacokinetic parameters tissue distribution Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2012 ftdoajarticles https://doi.org/10.1590/S1678-91992012000400005 2023-01-08T01:29:49Z The purpose of the present study was to investigate the biodistribution profile of the venom of Hemiscorpius lepturus, the most dangerous scorpion in Iran. Blood and tissue samples were taken at various predetermined intervals during a 400-minute period for the venom and a 360-minute period for the antivenom in rats. The radio-iodination was carried out using the chloramine-T method. The results showed that the descending order of venom uptake was skin, kidneys and intestine, respectively. The descending order of polyclonal antivenom uptake was kidneys, intestine, heart and lungs. The calculated pharmacokinetic parameters of the venom were Telimination half-life = 521.5 ± 12.6 minutes; Vd/F (apparent volume of distribution) = 14.9 ± 3.3 mL; clearance (CL/F, apparent total clearance of the drug from plasma) 0.02 ± 0.005 mL/minute and for the antivenom Telimination half-life = 113.7 ± 7.4 minutes; Vd/F = 13 ± 1.2 mL and CL/F 0.08 ± 0.01 mL/minute. The pharmacokinetics profile comparison of the venom with that of the antivenom shows that serotherapy may be more effective if administered within 2-4 hours following envenomation by H. lepturus. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 18 4 375 383 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Hemiscorpius lepturus scorpion venom polyvalent antivenom pharmacokinetic parameters tissue distribution Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Hemiscorpius lepturus scorpion venom polyvalent antivenom pharmacokinetic parameters tissue distribution Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 R Seyedian A Jalali MH Babaee MH Pipelzadeh S Rezaee A biodistribution study of Hemiscorpius lepturus scorpion venom and available polyclonal antivenom in rats |
topic_facet |
Hemiscorpius lepturus scorpion venom polyvalent antivenom pharmacokinetic parameters tissue distribution Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
The purpose of the present study was to investigate the biodistribution profile of the venom of Hemiscorpius lepturus, the most dangerous scorpion in Iran. Blood and tissue samples were taken at various predetermined intervals during a 400-minute period for the venom and a 360-minute period for the antivenom in rats. The radio-iodination was carried out using the chloramine-T method. The results showed that the descending order of venom uptake was skin, kidneys and intestine, respectively. The descending order of polyclonal antivenom uptake was kidneys, intestine, heart and lungs. The calculated pharmacokinetic parameters of the venom were Telimination half-life = 521.5 ± 12.6 minutes; Vd/F (apparent volume of distribution) = 14.9 ± 3.3 mL; clearance (CL/F, apparent total clearance of the drug from plasma) 0.02 ± 0.005 mL/minute and for the antivenom Telimination half-life = 113.7 ± 7.4 minutes; Vd/F = 13 ± 1.2 mL and CL/F 0.08 ± 0.01 mL/minute. The pharmacokinetics profile comparison of the venom with that of the antivenom shows that serotherapy may be more effective if administered within 2-4 hours following envenomation by H. lepturus. |
format |
Article in Journal/Newspaper |
author |
R Seyedian A Jalali MH Babaee MH Pipelzadeh S Rezaee |
author_facet |
R Seyedian A Jalali MH Babaee MH Pipelzadeh S Rezaee |
author_sort |
R Seyedian |
title |
A biodistribution study of Hemiscorpius lepturus scorpion venom and available polyclonal antivenom in rats |
title_short |
A biodistribution study of Hemiscorpius lepturus scorpion venom and available polyclonal antivenom in rats |
title_full |
A biodistribution study of Hemiscorpius lepturus scorpion venom and available polyclonal antivenom in rats |
title_fullStr |
A biodistribution study of Hemiscorpius lepturus scorpion venom and available polyclonal antivenom in rats |
title_full_unstemmed |
A biodistribution study of Hemiscorpius lepturus scorpion venom and available polyclonal antivenom in rats |
title_sort |
biodistribution study of hemiscorpius lepturus scorpion venom and available polyclonal antivenom in rats |
publisher |
SciELO |
publishDate |
2012 |
url |
https://doi.org/10.1590/S1678-91992012000400005 https://doaj.org/article/b6cd48693c9248a3a94609839a822b3d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 18, Iss 4, Pp 375-383 (2012) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000400005 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992012000400005 1678-9199 https://doaj.org/article/b6cd48693c9248a3a94609839a822b3d |
op_doi |
https://doi.org/10.1590/S1678-91992012000400005 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
18 |
container_issue |
4 |
container_start_page |
375 |
op_container_end_page |
383 |
_version_ |
1766339220268384256 |