First clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple Culicoides allergens
Background Insect bite hypersensitivity (IBH) is an IgE-mediated allergic dermatitis in horses incited by salivary allergens from Culicoides spp. IBH does not occur in Iceland, as the causative agents are absent, however a high prevalence is seen in horses exported to Culicoides-rich environments. A...
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ftdoajarticles:oai:doaj.org/article:b6b9baa470d54a50894c2c1488281b40 2023-05-15T16:46:23+02:00 First clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple Culicoides allergens Jasmin Birras Samuel J. White Sigridur Jonsdottir Ella N. Novotny Anja Ziegler A. Douglas Wilson Rebecka Frey Sigurbjörg Torsteinsdottir Marcos Alcocer Eliane Marti 2021-01-01T00:00:00Z https://doaj.org/article/b6b9baa470d54a50894c2c1488281b40 EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592417/?tool=EBI https://doaj.org/toc/1932-6203 1932-6203 https://doaj.org/article/b6b9baa470d54a50894c2c1488281b40 PLoS ONE, Vol 16, Iss 11 (2021) Medicine R Science Q article 2021 ftdoajarticles 2022-12-31T09:16:00Z Background Insect bite hypersensitivity (IBH) is an IgE-mediated allergic dermatitis in horses incited by salivary allergens from Culicoides spp. IBH does not occur in Iceland, as the causative agents are absent, however a high prevalence is seen in horses exported to Culicoides-rich environments. Aims To study the natural course of sensitization to Culicoides allergens and identify the primary sensitizing allergen(s) in horses exported from Iceland utilizing a comprehensive panel of Culicoides recombinant (r-) allergens. Method IgE microarray profiling to 27 Culicoides r-allergens was conducted on 110 serological samples from horses imported to Switzerland from Iceland that subsequently developed IBH or remained healthy. Furthermore, a longitudinal study of 31 IBH horses determined IgE profiles the summer preceding first clinical signs of IBH (TIBH-1), the summer of first clinical signs (TIBH) and the following summer (TIBH+1). In a group of Icelandic horses residing in Sweden, effects of origin (born in Iceland or Sweden) and duration of IBH (<4 years, 4–7 years, >7 years) on Culicoides-specific IgE was evaluated. Sero-positivity rates and IgE levels were compared. Results At TIBH, horses were sensitized to a median of 11 r-allergens (range = 0–21), of which nine were major allergens. This was significantly higher than TIBH-1 (3, 0–16), as well as the healthy (1, 0–14) group. There was no significant increase between TIBH and TIBH+1(12, 0–23). IBH-affected horses exported from Iceland had a significantly higher degree of sensitization than those born in Europe, while duration of IBH did not significantly affect degree of sensitization. Conclusion Significant sensitization is only detected in serum the year of first clinical signs of IBH. Horses become sensitized simultaneously to multiple Culicoides r-allergens, indicating that IgE-reactivity is due to co-sensitization rather than cross-reactivity between Culicoides allergens. Nine major first sensitizing r-allergens have been identified, which could be ... Article in Journal/Newspaper Iceland Directory of Open Access Journals: DOAJ Articles |
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Medicine R Science Q Jasmin Birras Samuel J. White Sigridur Jonsdottir Ella N. Novotny Anja Ziegler A. Douglas Wilson Rebecka Frey Sigurbjörg Torsteinsdottir Marcos Alcocer Eliane Marti First clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple Culicoides allergens |
topic_facet |
Medicine R Science Q |
description |
Background Insect bite hypersensitivity (IBH) is an IgE-mediated allergic dermatitis in horses incited by salivary allergens from Culicoides spp. IBH does not occur in Iceland, as the causative agents are absent, however a high prevalence is seen in horses exported to Culicoides-rich environments. Aims To study the natural course of sensitization to Culicoides allergens and identify the primary sensitizing allergen(s) in horses exported from Iceland utilizing a comprehensive panel of Culicoides recombinant (r-) allergens. Method IgE microarray profiling to 27 Culicoides r-allergens was conducted on 110 serological samples from horses imported to Switzerland from Iceland that subsequently developed IBH or remained healthy. Furthermore, a longitudinal study of 31 IBH horses determined IgE profiles the summer preceding first clinical signs of IBH (TIBH-1), the summer of first clinical signs (TIBH) and the following summer (TIBH+1). In a group of Icelandic horses residing in Sweden, effects of origin (born in Iceland or Sweden) and duration of IBH (<4 years, 4–7 years, >7 years) on Culicoides-specific IgE was evaluated. Sero-positivity rates and IgE levels were compared. Results At TIBH, horses were sensitized to a median of 11 r-allergens (range = 0–21), of which nine were major allergens. This was significantly higher than TIBH-1 (3, 0–16), as well as the healthy (1, 0–14) group. There was no significant increase between TIBH and TIBH+1(12, 0–23). IBH-affected horses exported from Iceland had a significantly higher degree of sensitization than those born in Europe, while duration of IBH did not significantly affect degree of sensitization. Conclusion Significant sensitization is only detected in serum the year of first clinical signs of IBH. Horses become sensitized simultaneously to multiple Culicoides r-allergens, indicating that IgE-reactivity is due to co-sensitization rather than cross-reactivity between Culicoides allergens. Nine major first sensitizing r-allergens have been identified, which could be ... |
format |
Article in Journal/Newspaper |
author |
Jasmin Birras Samuel J. White Sigridur Jonsdottir Ella N. Novotny Anja Ziegler A. Douglas Wilson Rebecka Frey Sigurbjörg Torsteinsdottir Marcos Alcocer Eliane Marti |
author_facet |
Jasmin Birras Samuel J. White Sigridur Jonsdottir Ella N. Novotny Anja Ziegler A. Douglas Wilson Rebecka Frey Sigurbjörg Torsteinsdottir Marcos Alcocer Eliane Marti |
author_sort |
Jasmin Birras |
title |
First clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple Culicoides allergens |
title_short |
First clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple Culicoides allergens |
title_full |
First clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple Culicoides allergens |
title_fullStr |
First clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple Culicoides allergens |
title_full_unstemmed |
First clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple Culicoides allergens |
title_sort |
first clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple culicoides allergens |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doaj.org/article/b6b9baa470d54a50894c2c1488281b40 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
PLoS ONE, Vol 16, Iss 11 (2021) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592417/?tool=EBI https://doaj.org/toc/1932-6203 1932-6203 https://doaj.org/article/b6b9baa470d54a50894c2c1488281b40 |
_version_ |
1766036481702363136 |