Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient
Abstract Background The importance of vascular occlusion in the pathogenesis of human haemoprotozoal disease is unresolved. Methods Giemsa-stained tissue sections from a human case of Babesia microti infection in a splenectomized patient with chronic lymphocytic leukaemia and colon cancer were exami...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2006
|
Subjects: | |
Online Access: | https://doi.org/10.1186/1475-2875-5-69 https://doaj.org/article/b698a459ee4c4fb481189ff063f64c7e |
id |
ftdoajarticles:oai:doaj.org/article:b698a459ee4c4fb481189ff063f64c7e |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:b698a459ee4c4fb481189ff063f64c7e 2023-05-15T15:01:21+02:00 Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient Joyce Alina J Haymore Bret R Hsue Gunther Budd Alison C Clark Ian A Thorner Richard Krause Peter J 2006-08-01T00:00:00Z https://doi.org/10.1186/1475-2875-5-69 https://doaj.org/article/b698a459ee4c4fb481189ff063f64c7e EN eng BMC http://www.malariajournal.com/content/5/1/69 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-5-69 1475-2875 https://doaj.org/article/b698a459ee4c4fb481189ff063f64c7e Malaria Journal, Vol 5, Iss 1, p 69 (2006) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2006 ftdoajarticles https://doi.org/10.1186/1475-2875-5-69 2022-12-31T00:53:43Z Abstract Background The importance of vascular occlusion in the pathogenesis of human haemoprotozoal disease is unresolved. Methods Giemsa-stained tissue sections from a human case of Babesia microti infection in a splenectomized patient with chronic lymphocytic leukaemia and colon cancer were examined to ascertain the distribution of parasitized erythrocytes within the vascular lumen. Results No evidence of sequestration was observed. Conclusion This first report on the vascular location of B. microti in human tissue suggests that severe multi-organ failure due to babesiosis is independent of sequestration of parasitized erythrocytes. A similar pathogenesis may also cause multi-organ failure in other intraerythrocytic protozoal infections, including falciparum malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 5 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Joyce Alina J Haymore Bret R Hsue Gunther Budd Alison C Clark Ian A Thorner Richard Krause Peter J Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The importance of vascular occlusion in the pathogenesis of human haemoprotozoal disease is unresolved. Methods Giemsa-stained tissue sections from a human case of Babesia microti infection in a splenectomized patient with chronic lymphocytic leukaemia and colon cancer were examined to ascertain the distribution of parasitized erythrocytes within the vascular lumen. Results No evidence of sequestration was observed. Conclusion This first report on the vascular location of B. microti in human tissue suggests that severe multi-organ failure due to babesiosis is independent of sequestration of parasitized erythrocytes. A similar pathogenesis may also cause multi-organ failure in other intraerythrocytic protozoal infections, including falciparum malaria. |
format |
Article in Journal/Newspaper |
author |
Joyce Alina J Haymore Bret R Hsue Gunther Budd Alison C Clark Ian A Thorner Richard Krause Peter J |
author_facet |
Joyce Alina J Haymore Bret R Hsue Gunther Budd Alison C Clark Ian A Thorner Richard Krause Peter J |
author_sort |
Joyce Alina J |
title |
Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient |
title_short |
Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient |
title_full |
Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient |
title_fullStr |
Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient |
title_full_unstemmed |
Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient |
title_sort |
absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient |
publisher |
BMC |
publishDate |
2006 |
url |
https://doi.org/10.1186/1475-2875-5-69 https://doaj.org/article/b698a459ee4c4fb481189ff063f64c7e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 5, Iss 1, p 69 (2006) |
op_relation |
http://www.malariajournal.com/content/5/1/69 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-5-69 1475-2875 https://doaj.org/article/b698a459ee4c4fb481189ff063f64c7e |
op_doi |
https://doi.org/10.1186/1475-2875-5-69 |
container_title |
Malaria Journal |
container_volume |
5 |
container_issue |
1 |
_version_ |
1766333379097133056 |