Mining nematode protein secretomes to explain lifestyle and host specificity.
Parasitic nematodes are highly successful pathogens, inflicting disease on humans, animals and plants. Despite great differences in their life cycles, host preference and transmission modes, these parasites share a common capacity to manipulate their host's immune system. This is at least partl...
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ftdoajarticles:oai:doaj.org/article:b69745fa329f4bf79a314a4a95810598 2023-05-15T15:09:02+02:00 Mining nematode protein secretomes to explain lifestyle and host specificity. Lucienne Tritten Cristina Ballesteros Robin Beech Timothy G Geary Yovany Moreno 2021-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009828 https://doaj.org/article/b69745fa329f4bf79a314a4a95810598 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009828 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009828 https://doaj.org/article/b69745fa329f4bf79a314a4a95810598 PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009828 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009828 2022-12-31T11:29:28Z Parasitic nematodes are highly successful pathogens, inflicting disease on humans, animals and plants. Despite great differences in their life cycles, host preference and transmission modes, these parasites share a common capacity to manipulate their host's immune system. This is at least partly achieved through the release of excretory/secretory proteins, the most well-characterized component of nematode secretomes, that are comprised of functionally diverse molecules. In this work, we analyzed published protein secretomes of parasitic nematodes to identify common patterns as well as species-specific traits. The 20 selected organisms span 4 nematode clades, including plant pathogens, animal parasites, and the free-living species Caenorhabditis elegans. Transthyretin-like proteins were the only component common to all adult secretomes; many other protein classes overlapped across multiple datasets. The glycolytic enzymes aldolase and enolase were present in all parasitic species, but missing from C. elegans. Secretomes from larval stages showed less overlap between species. Although comparison of secretome composition across species and life-cycle stages is challenged by the use of different methods and depths of sequencing among studies, our workflow enabled the identification of conserved protein families and pinpointed elements that may have evolved as to enable parasitism. This strategy, extended to more secretomes, may be exploited to prioritize therapeutic targets in the future. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 9 e0009828 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Lucienne Tritten Cristina Ballesteros Robin Beech Timothy G Geary Yovany Moreno Mining nematode protein secretomes to explain lifestyle and host specificity. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Parasitic nematodes are highly successful pathogens, inflicting disease on humans, animals and plants. Despite great differences in their life cycles, host preference and transmission modes, these parasites share a common capacity to manipulate their host's immune system. This is at least partly achieved through the release of excretory/secretory proteins, the most well-characterized component of nematode secretomes, that are comprised of functionally diverse molecules. In this work, we analyzed published protein secretomes of parasitic nematodes to identify common patterns as well as species-specific traits. The 20 selected organisms span 4 nematode clades, including plant pathogens, animal parasites, and the free-living species Caenorhabditis elegans. Transthyretin-like proteins were the only component common to all adult secretomes; many other protein classes overlapped across multiple datasets. The glycolytic enzymes aldolase and enolase were present in all parasitic species, but missing from C. elegans. Secretomes from larval stages showed less overlap between species. Although comparison of secretome composition across species and life-cycle stages is challenged by the use of different methods and depths of sequencing among studies, our workflow enabled the identification of conserved protein families and pinpointed elements that may have evolved as to enable parasitism. This strategy, extended to more secretomes, may be exploited to prioritize therapeutic targets in the future. |
format |
Article in Journal/Newspaper |
author |
Lucienne Tritten Cristina Ballesteros Robin Beech Timothy G Geary Yovany Moreno |
author_facet |
Lucienne Tritten Cristina Ballesteros Robin Beech Timothy G Geary Yovany Moreno |
author_sort |
Lucienne Tritten |
title |
Mining nematode protein secretomes to explain lifestyle and host specificity. |
title_short |
Mining nematode protein secretomes to explain lifestyle and host specificity. |
title_full |
Mining nematode protein secretomes to explain lifestyle and host specificity. |
title_fullStr |
Mining nematode protein secretomes to explain lifestyle and host specificity. |
title_full_unstemmed |
Mining nematode protein secretomes to explain lifestyle and host specificity. |
title_sort |
mining nematode protein secretomes to explain lifestyle and host specificity. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009828 https://doaj.org/article/b69745fa329f4bf79a314a4a95810598 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009828 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009828 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009828 https://doaj.org/article/b69745fa329f4bf79a314a4a95810598 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009828 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
9 |
container_start_page |
e0009828 |
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1766340275684245504 |