Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine
Abstract In many parts of the African Sahel and sub-Sahel, where malaria remains a major cause of mortality and morbidity, transmission of the infection is highly seasonal. Seasonal malaria chemoprevention (SMC), which involves administration of a full course of malaria treatment to young children a...
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ftdoajarticles:oai:doaj.org/article:b625908b55744d9b9202da0cf15006de 2023-05-15T15:13:32+02:00 Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine Brian Greenwood Alassane Dicko Issaka Sagara Issaka Zongo Halidou Tinto Matthew Cairns Irene Kuepfer Paul Milligan Jean-Bosco Ouedraogo Ogobara Doumbo Daniel Chandramohan 2017-05-01T00:00:00Z https://doi.org/10.1186/s12936-017-1841-9 https://doaj.org/article/b625908b55744d9b9202da0cf15006de EN eng BMC http://link.springer.com/article/10.1186/s12936-017-1841-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-1841-9 1475-2875 https://doaj.org/article/b625908b55744d9b9202da0cf15006de Malaria Journal, Vol 16, Iss 1, Pp 1-5 (2017) Seasonal malaria transmission Seasonal malaria chemoprevention Seasonal malaria vaccination Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2017 ftdoajarticles https://doi.org/10.1186/s12936-017-1841-9 2022-12-31T02:50:48Z Abstract In many parts of the African Sahel and sub-Sahel, where malaria remains a major cause of mortality and morbidity, transmission of the infection is highly seasonal. Seasonal malaria chemoprevention (SMC), which involves administration of a full course of malaria treatment to young children at monthly intervals during the high transmission season, is proving to be an effective malaria control measure in these areas. However, SMC does not provide complete protection and it is demanding to deliver for both families and healthcare givers. Furthermore, there is a risk of the emergence in the future of resistance to the drugs, sulfadoxine–pyrimethamine and amodiaquine, that are currently being used for SMC. Substantial progress has been made in the development of malaria vaccines during the past decade and one malaria vaccine, RTS,S/AS01, has received a positive opinion from the European Medicines Authority and will soon be deployed in large-scale, pilot implementation projects in sub-Saharan Africa. A characteristic feature of this vaccine, and potentially of some of the other malaria vaccines under development, is that they provide a high level of efficacy during the period immediately after vaccination, but that this wanes rapidly, perhaps because it is difficult to develop effective immunological memory to malaria antigens in subjects exposed previously to malaria infection. A potentially effective way of using malaria vaccines with high initial efficacy but which provide only a short period of protection could be annual, mass vaccination campaigns shortly before each malaria transmission season in areas where malaria transmission is confined largely to a few months of the year. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 16 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Seasonal malaria transmission Seasonal malaria chemoprevention Seasonal malaria vaccination Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Seasonal malaria transmission Seasonal malaria chemoprevention Seasonal malaria vaccination Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Brian Greenwood Alassane Dicko Issaka Sagara Issaka Zongo Halidou Tinto Matthew Cairns Irene Kuepfer Paul Milligan Jean-Bosco Ouedraogo Ogobara Doumbo Daniel Chandramohan Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine |
topic_facet |
Seasonal malaria transmission Seasonal malaria chemoprevention Seasonal malaria vaccination Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract In many parts of the African Sahel and sub-Sahel, where malaria remains a major cause of mortality and morbidity, transmission of the infection is highly seasonal. Seasonal malaria chemoprevention (SMC), which involves administration of a full course of malaria treatment to young children at monthly intervals during the high transmission season, is proving to be an effective malaria control measure in these areas. However, SMC does not provide complete protection and it is demanding to deliver for both families and healthcare givers. Furthermore, there is a risk of the emergence in the future of resistance to the drugs, sulfadoxine–pyrimethamine and amodiaquine, that are currently being used for SMC. Substantial progress has been made in the development of malaria vaccines during the past decade and one malaria vaccine, RTS,S/AS01, has received a positive opinion from the European Medicines Authority and will soon be deployed in large-scale, pilot implementation projects in sub-Saharan Africa. A characteristic feature of this vaccine, and potentially of some of the other malaria vaccines under development, is that they provide a high level of efficacy during the period immediately after vaccination, but that this wanes rapidly, perhaps because it is difficult to develop effective immunological memory to malaria antigens in subjects exposed previously to malaria infection. A potentially effective way of using malaria vaccines with high initial efficacy but which provide only a short period of protection could be annual, mass vaccination campaigns shortly before each malaria transmission season in areas where malaria transmission is confined largely to a few months of the year. |
format |
Article in Journal/Newspaper |
author |
Brian Greenwood Alassane Dicko Issaka Sagara Issaka Zongo Halidou Tinto Matthew Cairns Irene Kuepfer Paul Milligan Jean-Bosco Ouedraogo Ogobara Doumbo Daniel Chandramohan |
author_facet |
Brian Greenwood Alassane Dicko Issaka Sagara Issaka Zongo Halidou Tinto Matthew Cairns Irene Kuepfer Paul Milligan Jean-Bosco Ouedraogo Ogobara Doumbo Daniel Chandramohan |
author_sort |
Brian Greenwood |
title |
Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine |
title_short |
Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine |
title_full |
Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine |
title_fullStr |
Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine |
title_full_unstemmed |
Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine |
title_sort |
seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine |
publisher |
BMC |
publishDate |
2017 |
url |
https://doi.org/10.1186/s12936-017-1841-9 https://doaj.org/article/b625908b55744d9b9202da0cf15006de |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 16, Iss 1, Pp 1-5 (2017) |
op_relation |
http://link.springer.com/article/10.1186/s12936-017-1841-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-1841-9 1475-2875 https://doaj.org/article/b625908b55744d9b9202da0cf15006de |
op_doi |
https://doi.org/10.1186/s12936-017-1841-9 |
container_title |
Malaria Journal |
container_volume |
16 |
container_issue |
1 |
_version_ |
1766344085199650816 |