Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial
Abstract Background Biannual mass azithromycin administration to preschool children reduces all-cause mortality, but the mechanism for the effect is not understood. Azithromycin has activity against malaria parasites, and malaria is a leading cause of child mortality in the Sahel. The effect of bian...
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ftdoajarticles:oai:doaj.org/article:b62043bd2b384aaaa58287e2aaa0dd02 2023-05-15T15:13:23+02:00 Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial Catherine E. Oldenburg Abdou Amza Gretchen Cooley Boubacar Kadri Beido Nassirou Benjamin F. Arnold Philip J. Rosenthal Kieran S. O’Brien Sheila K. West Robin L. Bailey Travis C. Porco Jeremy D. Keenan Thomas M. Lietman Diana L. Martin 2019-12-01T00:00:00Z https://doi.org/10.1186/s12936-019-3033-2 https://doaj.org/article/b62043bd2b384aaaa58287e2aaa0dd02 EN eng BMC https://doi.org/10.1186/s12936-019-3033-2 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-3033-2 1475-2875 https://doaj.org/article/b62043bd2b384aaaa58287e2aaa0dd02 Malaria Journal, Vol 18, Iss 1, Pp 1-9 (2019) Malaria Azithromycin Niger Mass drug administration Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-3033-2 2022-12-31T13:34:33Z Abstract Background Biannual mass azithromycin administration to preschool children reduces all-cause mortality, but the mechanism for the effect is not understood. Azithromycin has activity against malaria parasites, and malaria is a leading cause of child mortality in the Sahel. The effect of biannual versus annual azithromycin distribution for trachoma control on serological response to merozoite surface protein 1 (MSP-119), a surrogate for malaria incidence, was evaluated among children in Niger. Methods Markers of malaria exposure were measured in two arms of a factorial randomized controlled trial designed to evaluate targeted biannual azithromycin distribution to children under 12 years of age compared to annual azithromycin to the entire community for trachoma control (N = 12 communities per arm). Communities were treated for 36 months (6 versus 3 distributions). Dried blood spots were collected at 36 months among children ages 1–5 years, and MSP-119 antibody levels were assessed using a bead-based multiplex assay to measure malaria seroprevalence. Results Antibody results were available for 991 children. MSP-119 seropositivity was 62.7% in the biannual distribution arm compared to 68.7% in the annual arm (prevalence ratio 0.91, 95% CI 0.83 to 1.00). Mean semi-quantitative antibody levels were lower in the biannual distribution arm compared to the annual arm (mean difference − 0.39, 95% CI − 0.05 to − 0.72). Conclusions Targeted biannual azithromycin distribution was associated with lower malaria seroprevalence compared to that in a population that received annual distribution. Trial Registration Clinicaltrials.gov NCT00792922 Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Malaria Azithromycin Niger Mass drug administration Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Malaria Azithromycin Niger Mass drug administration Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Catherine E. Oldenburg Abdou Amza Gretchen Cooley Boubacar Kadri Beido Nassirou Benjamin F. Arnold Philip J. Rosenthal Kieran S. O’Brien Sheila K. West Robin L. Bailey Travis C. Porco Jeremy D. Keenan Thomas M. Lietman Diana L. Martin Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial |
topic_facet |
Malaria Azithromycin Niger Mass drug administration Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Biannual mass azithromycin administration to preschool children reduces all-cause mortality, but the mechanism for the effect is not understood. Azithromycin has activity against malaria parasites, and malaria is a leading cause of child mortality in the Sahel. The effect of biannual versus annual azithromycin distribution for trachoma control on serological response to merozoite surface protein 1 (MSP-119), a surrogate for malaria incidence, was evaluated among children in Niger. Methods Markers of malaria exposure were measured in two arms of a factorial randomized controlled trial designed to evaluate targeted biannual azithromycin distribution to children under 12 years of age compared to annual azithromycin to the entire community for trachoma control (N = 12 communities per arm). Communities were treated for 36 months (6 versus 3 distributions). Dried blood spots were collected at 36 months among children ages 1–5 years, and MSP-119 antibody levels were assessed using a bead-based multiplex assay to measure malaria seroprevalence. Results Antibody results were available for 991 children. MSP-119 seropositivity was 62.7% in the biannual distribution arm compared to 68.7% in the annual arm (prevalence ratio 0.91, 95% CI 0.83 to 1.00). Mean semi-quantitative antibody levels were lower in the biannual distribution arm compared to the annual arm (mean difference − 0.39, 95% CI − 0.05 to − 0.72). Conclusions Targeted biannual azithromycin distribution was associated with lower malaria seroprevalence compared to that in a population that received annual distribution. Trial Registration Clinicaltrials.gov NCT00792922 |
format |
Article in Journal/Newspaper |
author |
Catherine E. Oldenburg Abdou Amza Gretchen Cooley Boubacar Kadri Beido Nassirou Benjamin F. Arnold Philip J. Rosenthal Kieran S. O’Brien Sheila K. West Robin L. Bailey Travis C. Porco Jeremy D. Keenan Thomas M. Lietman Diana L. Martin |
author_facet |
Catherine E. Oldenburg Abdou Amza Gretchen Cooley Boubacar Kadri Beido Nassirou Benjamin F. Arnold Philip J. Rosenthal Kieran S. O’Brien Sheila K. West Robin L. Bailey Travis C. Porco Jeremy D. Keenan Thomas M. Lietman Diana L. Martin |
author_sort |
Catherine E. Oldenburg |
title |
Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial |
title_short |
Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial |
title_full |
Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial |
title_fullStr |
Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial |
title_full_unstemmed |
Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial |
title_sort |
biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in niger: a sub-study of a cluster randomized trial |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-3033-2 https://doaj.org/article/b62043bd2b384aaaa58287e2aaa0dd02 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-9 (2019) |
op_relation |
https://doi.org/10.1186/s12936-019-3033-2 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-3033-2 1475-2875 https://doaj.org/article/b62043bd2b384aaaa58287e2aaa0dd02 |
op_doi |
https://doi.org/10.1186/s12936-019-3033-2 |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
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1766343947322392576 |